Strenuous, intensive, long-term exercise does not prevent or delay the onset of Huntington's disease

Medical Hypotheses

Volumn 67, Issue 6, 2006, Pages 1429-1430

  Altschuler, Eric Lewin ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CASE REPORT; EXERCISE; GENETIC DISORDER; HUMAN; HUNTINGTON CHOREA; MARATHON RUNNER; PRIORITY JOURNAL; RUNNING; SPORT;

AGE OF ONSET; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EXERCISE; HUMANS; HUNTINGTON DISEASE; MICE; MODELS, BIOLOGICAL; PHYSICAL ENDURANCE;

ELAGATIS;

EID: 33748971888     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.04.068     Document Type: Article

References (6)

1. Langbehn D.R., Brinkman R.R., Falush D., et al. A new model for the prediction of the age of onset and penetrance for Huntington's disease based on the CAG length. Clin Genet 65 (2004) 267-277
2. van Dellen A., Blakemore C., Deacon R., et al. Delaying the onset of Huntington's in mice. Nature 404 (2000) 721-722
3. Hockly E., Codery P.M., Woodman B., et al. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Ann Neurol 51 (2002) 235-242
4. Spires T.L., Grote H.E., Varshney N.K., et al. Environmental enrichment rescues protein deficit in a mouse model of Huntington's disease indicating a possible disease mechanism. J Neurosci 24 (2004) 2270-2276
5. Kosinski CM, Sellhaus B, Schlange C, Young AB, Landwehrmeyer BG, Lindenberg KS. Myopathy as first sign of Huntington's disease in a marathon runner. Society for Neurosciences (Abstr.) Program No. 212.5, Washington, DC, November, 2005. [The text of the abstract can be freely accessed at http://sfn.scholarone.com/itin2005/]
6. Sullivan F.R., Bird E.D., Aplay M., and Cha J.H. Remotivation therapy and Huntington's disease. J Neurosci Nurs 33 (2001) 136-142