Immunohistochemical expression of p63 in endometrial polyps: Evidence that a basal cell immunophenotype is maintained

Menopause

Volumn 13, Issue 5, 2006, Pages 826-830

  Nogueira, Antonio Alberto ^a,b   Sant'Ana De Almeida, Elza Carvalho ^a   Poli Neto, Omero Benedicto ^a   Zambelli Ramalho, Leandra Naira ^a   Rosa E Silva, Júlio César ^a   Candido Dos Reis, Francisco José ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Endometrium; p63; Polyp; Postmenopause; Reserve cells

Indexed keywords

PROTEIN P63;

ADULT; AGED; ARTICLE; BASAL CELL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM; ENDOMETRIUM POLYP; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; PROTEIN EXPRESSION;

AGED; CHI-SQUARE DISTRIBUTION; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYSTEROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MEMBRANE PROTEINS; MIDDLE AGED; POLYPS; POSTMENOPAUSE; UTERINE DISEASES;

EID: 33748944850     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gme.0000227396.68439.c3     Document Type: Article

References (22)

1. Peterson WF, Novak ER. Endometrial polyps. Obstet Gynecol 1956;8:40-49.
2. Van Bogaert LJ. Clinicopathologic findings in endometrial polyps. Obstet Gynecol 1988;71:771-773.
3. Berliere M, Charles A, Galant C, Donnez J. Uterine side effects of tamoxifen: a need for systematic pretreatment screening. Obstet Gynecol 1998;91:40-44.
4. Wolfe SA, Mackles A. Malignant lesions arising from benign endometrial polyps. Obstet Gynecol 1962;20:542-550.
5. Anastasiadis PG, Koutlaki NG, Skaphida PG, Galazios GC, Tsikouras PN, Liberis VA. Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur J Gynaecol Oncol 2000;21:180-183.
6. Sant'Ana de Almeida EC, Nogueira AA, Candido dos Reis FJ, Zambelli Ramalho LN, Zucoloto S. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas 2004;49:229-233.
7. Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998;2:305-316.
8. Yan A, Schweitzer R, Sun D, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999;398:714-718.
9. Quade BJ, Yang A, Wang Y, et al. Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol 2001;80:24-29.
10. O'Connell JT, Mutter GL, Cviko A, et al. Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol 2001;80:30-36.
11. Wang TY, Chen BF, Yang YC, et al. Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum Pathol 2001;32:479-486.
12. Nagele F, O'Connor H, Davies A, Badawy A, Mohamed H, Magos A. 2500 Outpatient diagnostic hysteroscopies. Obstet Gynecol 1996;88:87-92.
13. Goldstein SR, Monteagudo A, Popiolek D, Mayberry P, Timor-Tritsch I. Evaluation of endometrial polyps. Am J Obstet Gynecol 2002;186:669-674.
14. Savelli L, De Iaco P, Santini D, et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol 2003;188:927-931.
15. Van den Bosch T, Van Schoubroeck D, Ameye L, De Brabanter J, Van Huffel S, Timmerman D. Ultrasound assessment of endometrial thickness and endometrial polyps in women on hormonal replacement therapy. Am J Obstet Gynecol 2003;188:1249-1253.
16. Janes SM, Lowell S, Hutter C. Epidermal stem cells. J Pathol 2002;197:479-491.
17. Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol 1999;113:1099-1105.
18. Signoretti S, Waltregny D, Dilks J, et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 2000;157:1769-1775.
19. Gargett CE. Stem cells in gynaecology. Aust N Z J Obstet Gynaecol 2004;44:380-386.
20. Taylor LJ, Jackson TL, Reid JG, Duffy SR. The differential expression of oestrogen receptors, progesterone receptors, Bcl-2 and Ki67 in endometrial polyps. Br J Obstet Gynaecol 2003;110:794-798.
21. Irwin MS, Kaelin WG. p53 family update: p73 and p63 develop their own identities. Cell Growth Differ 2001;12:337-349.
22. Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res 2000;60:4016-4020.