ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway

Journal of Cellular Biochemistry

Volumn 99, Issue 2, 2006, Pages 575-588

  Zhang, Yi Qiang ^a   Herman, Brian ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Apoptosis; ARC; Caspase; Mitochondria; Oxidative stress

Indexed keywords

APOPTOSIS REPRESSOR WITH A CARD DOMAIN PROTEIN; CASPASE 2; CASPASE 3; CYTOCHROME C; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PROTEIN BAX; REPRESSOR PROTEIN; THREONINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROTECTION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; HEART MUSCLE CELL; IMMUNOPRECIPITATION; INHIBITION KINETICS; MITOCHONDRIAL RESPIRATION; MYOBLAST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; TWO HYBRID SYSTEM;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CELL LINE; CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION; MITOCHONDRIA, HEART; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RATS; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33748940221     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20946     Document Type: Article

References (36)

1. Andersen MH, Becker JC, Straten P. 2005. Regulators of apoptosis: Suitable targets for immune therapy of cancer. Nat Rev Drug Discov 4:399-409.
2. Araya R, Uehara T, Nomura Y. 1998. Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria. FEBS Lett 439:168-172.
3. Aronis A, Madar Z, Tirosh O. 2005. Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis. Free Radic Biol Med 38:1221-1230.
4. Baliga BC, Read SH, Kumar S. 2004. The biochemical mechanism of caspase-2 activation. Cell Death Differ 11:1234-1241.
5. Chen X, Liang H, Van Remmen H, Vijg J, Richardson A. 2004. Catalase transgenic mice: Characterization and sensitivity to oxidative stress. Arch Biochem Biophys 422:197-210.
6. Deveraux QL, Reed JC. 1999. LAP family proteins-Suppressors of apoptosis. Genes Dev 13:239-252.
7. Deveraux QL, Stennicke HR, Salvesen GS, Reed JC. 1999. Endogenous inhibitors of caspases. J Clin Immunol 19:388-398.
8. Dowds TA, Sabban EL. 2001. Endogenous and exogenous ARC in serum withdrawal mediated PC12 cell apoptosis: A new pro-apoptotic role for ARC. Cell Death Differ 8:640-648.
9. Ekhterae D, Lin Z, Lundberg MS, Crow MT, Brosius FC III, Nunez G. 1999. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circ Res 85:e70-e77.
10. Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P. 2003. Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Proc Natl Acad Sci USA 100:16006-16011.
11. Fliss H, Gattinger D. 1996. Apoptosis in ischemic and reperfused rat myocardium. Circ Res 79:949-956.
12. Gao Z, Shao Y, Jiang X. 2005. Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. J Biol Chem 280:38271-38275.
13. Gustafsson AB, Sayen MR, Williams SD, Crow MT, Gottlieb RA. 2002. TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective. Circulation 106:735-739.
14. Gustafsson AB, Tsai JG, Logue SE, Crow MT, Gottlieb RA. 2004. Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. J Biol Chem 279:21233-21238.
15. Herman B, Krishnan RV, Centonze VE. 2004. Microscopic analysis of fluorescence resonance energy transfer (FRET). Methods Mol Biol 261:351-370.
16. Holly TA, Drincic A, Byun Y, Nakamura S, Harris K, Klocke FJ, Cryns VL. 1999. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardiol 31:1709-1715.
17. Hong YM, JoDG, Lee JY, Chang JW, Nam JH, Noh JY, Koh JY, Jung YK. 2003. Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia. FEBS Lett 543:170-173.
18. Kimes BW, Brandt BL. 1976. Properties of a clonal muscle cell line from rat heart. Exp Cell Res 98:367-381.
19. Koseki T, Inohara N, Chen S, Nunez G. 1998. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci USA 95:5156-5160.
20. Li PF, Li J, Muller EC, Otto A, Dietz R, von Harsdorf R. 2002. Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC. Mol Cell 10:247-258.
21. Lundberg KC, Szweda LI. 2004. Initiation of mitochondrial-mediated apoptosis during cardiac reperfusion. Arch Biochem Biophys 432:50-57.
22. McCaughan FM, Brown AL, Harrison DJ. 1994. The effect of inhibition of glutathione S-transferase P on the growth of the Jurkat human T cell line. J Pathol 172:357-362.
23. Mronga T, Stahnke T, Goldbaum O, Richter-Landsberg C. 2004. Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic cell death of oligodendrocytes. Glia 46:446-455.
24. Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN. 2004. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell 15:901-912.
25. Neuss M, Monticone R, Lundberg MS, Chesley AT, Fleck E, Crow MT. 2001. The apoptotic regulatory protein ARC (apoptosis repressor with caspase recruitment domain) prevents oxidant stress-mediated cell death by preserving mitochondrial function. J Biol Chem 276:33915-33922.
26. Nicholson DW. 2001. Apoptosis. Baiting death inhibitors. Nature 410:33-34.
27. Qin Y, Vanden Hoek TL, Wojcik K, Anderson T, Li CQ, Shao ZH, Becker LB, Hamann KJ. 2004. Caspase-dependent cytochrome c release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion. Am J Physiol Heart Circ Physiol 286:H2280-H2286.
28. Ran Q, Van Remmen H, Gu M, Qi W, Roberts LJ II, Prolla T, Richardson A. 2003. Embryonic fibroblasts from Gpx4+/- mice: A novel model for studying the role of membrane peroxidation in biological processes. Free Radic Biol Med 35:1101-1109.
29. Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ II, Herman B, Richardson A, Van Remmen H. 2004. Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem 279:55137-55146.
30. Takahashi A, Masuda A, Sun M, Centonze VE, Herman B. 2004. Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm). Brain Res Bull 62:497-504.
31. Takeyama N, Miki S, Hirakawa A, Tanaka T. 2002. Role of the mitochondrial permeability transition and cytochrome C release in hydrogen peroxide-induced apoptosis. Exp Cell Res 274:16-24.
32. Tenev T, Zachariou A, Wilson R, Ditzel M, Meier P. 2005. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol 7:70-77.
33. Troy CM, Shelanski ML. 2003. Caspase-2 redux. Cell Death Differ 10:101-107.
34. Van Remmen H, Salvador C, Yang H, Huang TT, Epstein CJ, Richardson A. 1999. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch Biochem Biophys 363:91-97.
35. Van Remmen H, Williams MD, Guo Z, Estlack L, Yang H, Carlson EJ, Epstein CJ, Huang TT, Richardson A. 2001. Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol 281:H1422-H1432.
36. Zhao ZQ, Velez DA, Wang NP, Hewan-Lowe KO, Nakamura M, Guyton RA, Vinten-Johansen J. 2001. Progressively developed myocardial apoptotic cell death during late phase of reperfusion. Apoptosis 6:279-290.