Homocysteine: Clinical significance and laboratory measurement

Laboratory Medicine

Volumn 37, Issue 9, 2006, Pages 551-553

  Hortin, Glen L ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

CARDIOVASCULAR RISK; CLINICAL LABORATORY; DRUG METABOLISM; HEART INFARCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; REVIEW; STROKE; VEIN THROMBOSIS;

EID: 33748937023     PISSN: 00075027     EISSN: None     Source Type: Journal    
DOI: 10.1309/93G5JG1BF44N65BQ     Document Type: Review

References (22)

1. McCully KS. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111-128.
2. Nygard O, Nordrehaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230-236.
3. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. JAMA. 2002;288:2015-2022.
4. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and alzheimer's disease. N Engl J Med. 2002;346:476-483.
5. McLean RR, Jacques PF, Selhub J, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004;350:2042-2049.
6. Mudd SH, Levy HL, Kraus JP. Disorders of Transsulfuration, In: The Metabolic & Molecular Bases of Inherited Disease, 8th edition, Ed: CR Scriver, AL Beaudet, WS Sly, et al. New York: McGraw Hill, 2001; 2007-2056.
7. Yap S. Classical homocystinuria: Vascular risk and its prevention. J Inherit Metab Dis. 2003;26:259-265.
8. Lentz SR. Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost. 2005;3:1646-1654.
9. Refsum H, Smith AD, Ueland PM, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem. 2004;50:3-32.
10. Schwab U, Torronen A, Meririnne E, et al. Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J Nutr. 2006;136:34-38.
11. Olthof MR, Brink EJ, Katan MB, et al. Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. Am J Clin Pathol. 2005;82:111-117.
12. Ueland PM. Homocysteine species as components of plasma redox thiol status. Clin Chem. 1995;41:340-342.
13. McKinley MC, Strain JJ, McPartlin J, et al. Plasma homocysteine is not subject to seasonal variation. Clin Chem. 2001;47:1430-1436.
14. Verhoef P, van Vliet T, Olthof MR, et al. A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: A dietary controlled, crossover trial in healthy volunteers. Am J Clin Nutr. 2005;82:553-558.
15. Wolff F, Gausset P, Vanderpas J. Better stability of total homocysteine measurement with sodium fluoride than with EDTA. Clin Lab. 2005;51:275-278.
16. Nexo E, Engbaek F, Ueland PM, et al. Evaluation of novel assays in clinical chemistry: Quantification of plasma total homocysteine. Clin Chem. 2000;46:1150-1156.
17. Roberts RF, Roberts WL. Performance characteristics of a recombinant enzymatic cycling assay for quantification of total homocysteine in serum or plasma. Clin Chim Acta. 2004;344:95-99.
18. Tan Y, Sun X, Tang L, et al. Automated enzymatic assay for homocysteine. Clin Chem. 2003;49:1029-1030.
19. Dou C, Xia D, Zhang L, et al. Development of a novel enzymatic cycling assy for total homocysteine. Clin Chem. 2005;51:1987-1989.
20. Tuschl K, Bodamer OA, Erwa W, et al. Rapid analysis of total plasma homocysteine by tandem mass spectrometry. Clin Chim Acta. 2005;351:139-141.
21. Dierkes J, Westphal S. Effects of drugs on homocysteine concentrations. Semin Vasc Med. 2005;5:124-139.
22. Clarke R. Homocysteine-lowering trials for prevention of heart disease and stroke. Semin Vasc Med. 2005;5:215-222.