Differential associations for menopause and age in measures of vitamin K, osteocalcin, and bone density: A cross-sectional exploratory study in healthy volunteers

Menopause

Volumn 13, Issue 5, 2006, Pages 799-808

  Lukacs, Jane L ^a,f   Booth, Sarah ^b   Kleerekoper, Michael ^c   Ansbacher, Rudi ^d   Rock, Cheryl L ^e   Reame, Nancy E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b TUFTS UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d Obstetrics and Gynecology

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NONE   (United States)

Author keywords

Bone biomarkers; Fat soluble vitamins; Menopause; Osteocalcin; Reproductive aging

Indexed keywords

25 HYDROXYVITAMIN D; BIOLOGICAL MARKER; OSTEOCALCIN; PHYTOMENADIONE; RETINOL; SEX HORMONE; VITAMIN K GROUP;

ADULT; AGE; AGING; ARTICLE; BONE DENSITY; BONE TURNOVER; CARBOXYLATION; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTRADIOL BLOOD LEVEL; FEMALE; HIP; HUMAN; MENOPAUSE; POSTMENOPAUSE; SPINE; VITAMIN BLOOD LEVEL; VOLUNTEER;

ADULT; AGE FACTORS; AGING; BONE DENSITY; CHI-SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDIES; DENSITOMETRY, X-RAY; FEMALE; HUMANS; MENOPAUSE; MIDDLE AGED; OSTEOCALCIN; VITAMIN K;

EID: 33748926107     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gme.0000227023.89062.43     Document Type: Article

References (36)

1. Christiansen C, Christensen MS, Larsen NE, Transbol IB. Pathophysiological mechanisms of estrogen effect on bone metabolism. Dose-response relationships in early postmenopausal women. J Clin Endocrinol Metab 1982;55:1124-1130.
2. Bradsher JE, McKinlay SM. Distinguishing the effects of age from those of menopause. In: Lobo RA, Kelsey J, Marcus R, eds. Menopause Biology and Pathobiology. San Diego, CA: Academic Press, 2000:203-211.
3. Richelson LS, Wahner HW, Melton 3rd LJ, Riggs BL. Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl J Med 1984;311:1273-1275.
4. Calvo MS, Eyre DR, Gundberg CM. Molecular basis and clinical application of biological markers of bone turnover. Endocr Rev 1996;17:333-368.
5. Gambacciani M, Ciaponi M, Cappagli B, Benussi C, Genazzani AR. Longitudinal evaluation of perimenopausal femoral bone loss: effects of a low-dose oral contraceptive preparation on bone mineral density and metabolism. Osteoporos Int 2000;11:544-548.
6. Sowers MR, Finkelstein JS, Ettinger B, et al. The association of endogenous hormone concentrations and bone mineral density measures in pre- and perimenopausal women of four ethnic groups: SWAN. Osteoporos Int 2003;14:44-52.
7. Finkelstein JS, Sowers M, Greendale GA, et al. Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 2002;87:3051-3056.
8. 2+-binding protein of bone matrix. Haemostasis1986;16:258-272.
9. Price PA, Otsuka AA, Poser JW, Kristaponis J, Raman N. Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Proc Natl Acad Sci U S A 1976;73:1447-1451.
10. Gundberg CM, Nieman SD, Abrams S, Rosen H. Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 1998;83:3258-3266.
11. Szulc P, Chapuy MC, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 1993;91:1769-1774.
12. Szulc P, Chapuy MC, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 1996;18:487-488.
13. Knapen MH, Hamulyak K, Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Ann Intern Med 1989;111:1001-1005.
14. Sokoll LJ, Sadowski JA. Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. Am J Clin Nutr 1996;63:566-573.
15. Booth SL, Broe KE, Peterson JW, et al. Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab 2004;89:4904-4909.
16. Lukacs JL, Reame NE. Concentrations of follicle-stimulating hormone correlate with alkaline phosphatase and a marker for vitamin K status in the perimenopause. J Womens Health Gend Based Med 2000;9:731-739.
17. Douglas AS, Robins SP, Hutchison JD, Porter RW, Stewart A, Reid DM. Carboxylation of osteocalcin in postmenopausal osteoporotic women following vitamin K and D supplementation. Bone 1995;17:15-20.
18. 3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells. J Biol Chem 1980;255:11660-11663.
19. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-294.
20. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54.
21. Szulc P, Delmas PD. Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. Bone 1996;19:615-620.
22. Davidson KW, Sadowski JA. Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods Enzymol 1997;282:408-421.
23. Rock CL, Jahnke MG, Gorenflo DW, Swartz RD, Messana JM. Racial group differences in plasma concentrations of antioxidant vitamins and carotenoids in hemodialysis patients. Am J Clin Nutr 1997;65:844-850.
24. Sadowski JA, Hood SJ, Dallal GE, Garry PJ. Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. Am J Clin Nutr 1989;50:100-108.
25. McKeown NM, Rasmussen HM, Charnley JM, Wood RJ, Booth SL. Accuracy of phylloquinone (vitamin K-1) data in 2 nutrient databases as determined by direct laboratory analysis of diets. J Am Diet Assoc 2000;100:1201-1204.
26. Binkley NC, Krueger DC, Engelke JA, Foley AL, Suttie JW. Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. Am J Clin Nutr 2000;72:1523-1528.
27. Knapen MH, Nieuwenhuijzen Kruseman AC, Wouters RS, Vermeer C. Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 1998;63:375-379.
28. Vergnaud P, Garnero P, Meunier PJ, Breart G, Kamihagi K, Delmas PD. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 1997;82:719-724.
29. Hui SL, Zhou L, Evans R, et al. Rates of growth and loss of bone mineral in the spine and femoral neck in white females. Osteoporos Int 1999;9:200-205.
30. Melton LJ 3rd, Khosla S, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL. Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporos Int 2000;11:592-599.
31. Melton LJ 3rd, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL. Determinants of bone loss from the femoral neck in women of different ages. J Bone Miner Res 2000;15:24-31.
32. Karlsson MK, Obrant KJ, Nilsson BE, Johnell O. Changes in bone mineral, lean body mass and fat content as measured by dual energy X-ray absorptiometry: a longitudinal study. Calcif Tissue Int 2000;66:97-99.
33. Sowers M, Crutchfield M, Bandekar R, et al. Bone mineral density and its change in pre-and perimenopausalwhite women: the Michigan Bone Health Study. J Bone Miner Res 1998;13:1134-1140.
34. Arlot ME, Sornay-Rendu E, Garnero P, Vey-Marty B, Delmas PD. Apparent pre- and postmenopausal bone loss evaluated by DXA at different skeletal sites in women: the OFELY cohort. J Bone Miner Res 1997;12:683-690.
35. Warming L, Hassager C, Christiansen C. Changes in bone mineral density with age in men and women: a longitudinal study. Osteoporos Int 2002;13:105-112.
36. Ohta H, Masuzawa T, Ikeda T, Suda Y, Makita K, Nozawa S. Which is more osteoporosis-inducing, menopause or oophorectomy? Bone Miner 1992;19:273-285.