Strong calcium phosphate cement-chitosan-mesh construct containing cell-encapsulating hydrogel beads for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 77, Issue 3, 2006, Pages 487-496

  Weir, Michael D ^a   Xu, Hockin H K ^a,b   Simon Jr , Carl G ^b  

^a American Dental Association Foundation   (United States)

^b NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

Alginate hydrogel; Bone tissue engineering; Calcium phosphate cement; Cell encapsulation; Cytotoxicity; Macroporous; Mesh reinforcement

Indexed keywords

BONE CEMENT; CALCIUM PHOSPHATE; CYTOTOXICITY; ENCAPSULATION; POLYSACCHARIDES; TISSUE ENGINEERING;

ALGINATE HYDROGELS; BONE TISSUE ENGINEERING; CALCIUM PHOSPHATE CEMENT; CELL ENCAPSULATION; MACROPOROUS MATERIALS; MESH REINFORCEMENT;

HYDROGELS;

ALGINIC ACID; BONE CEMENT; CALCIUM PHOSPHATE; CHITOSAN;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; CALVARIA; CELL ENCAPSULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HYDROGEL; MECHANICAL STRESS; MOUSE; NONHUMAN; POROSITY; TISSUE ENGINEERING;

ALGINATES; ANIMALS; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CELLS, CULTURED; CHITOSAN; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGELS; MICE; OSTEOBLASTS; TISSUE ENGINEERING;

EID: 33748904518     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30626     Document Type: Article

References (38)

1. Salgado AJ, Coutinho OP, Reis RL. Bone tissue engineering: State of the art and future trends. Macromol Biosci 2004;4:743-765.
2. Laurencin CT, Ambrosio AMA, Borden MD, Cooper JA Jr. Tissue engineering: Orthopedic applications. Annu Rev Biomed Eng 1999;1:19-46.
3. Hulbert SF, Morrison SJ, Klawitter JJ. Tissue reaction to three ceramics of porous and non-porous structures. J Biomed Mater Res 1972;6:347-374.
4. LeGeros RZ, LeGeros JP. Dense hydroxyapatite. In: Hench LL, Wilson J, editors. Introduction to Bioceramics. New Jersey: World Scientific; 1993. p 139-180.
5. LeGeros RZ. Biodegradation and bioresorption of calcium phosphate ceramics. Clin Mater 1993;14:65-88.
6. Hench LL. Bioceramics. J Am Ceram Soc 1998;81:1705-1728.
7. Hing KA, Best SM, Bonfield W. Characterization of porous hydroxyapatite. J Mater Sci Mater Med 1999;10:135-145.
8. Durucan C, Brown PW. Low temperature formation of calcium-deficient hydroxyapatite-PLA/PLGA composites. J Biomed Mater Res 2000;51:717-725.
9. Pilliar RM, Filiaggi MJ, Wells JD, Grynpas MD, Kandel RA. Porous calcium polyphosphate scaffolds for bone substitute applications -in vitro characterization. Biomaterials 2001;22:963-972.
10. Chang MC, Ko CC, Douglas WH. Preparation of hydroxy apatite-gelatin nanocomposites. Biomaterials 2003;24:2853-2862.
11. Brown WE, Chow LC. A new calcium phosphate water setting cement. In: Brown PW, editor. Cements Research Progress. Westerville, OH: American Ceramic Society; 1986. p 352-379.
12. Costantino PD, Friedman CD, Jones K, Chow LC, Sisson GA. Experimental hydroxyapatite cement cranioplasty. Plast Reconstr Surg 1992;90:174-185.
13. Friedman CD, Costantino PD, Takagi S, Chow LC. BoneSource hydroxyapatite cement: A novel biomaterial for craniofacial skeletal tissue engineering and reconstruction. J Biomed Mater Res 1998;43:428-432.
14. Miyamoto Y, Ishikawa K, Takechi M, Toh T, Yuasa T, Nagayama M, Suzuki K. Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing. J Biomed Mater Res 1999;48:36-42.
15. Topoleski LDT, Ducheyne P, Cuckler JM. The fracture toughness of titanium-fiber-reinforced bone cement. J Biomed Mater Res 1992;26:1599-1617.
16. Topoleski LDT, Ducheyne P, Cuckler JM. The effects of centrifugation and titanium fiber reinforcement on fatigue failure mechanisms in poly(methyl methacrylate) bone cement. J Biomed Mater Res 1995;29:299-307.
17. Thomson RC, Yaszemski MJ, Powers JM, Mikos AG. Hydroxyapatite fiber reinforced poly(α-hydroxy ester)foams for bone regeneration. Biomaterials 1998;19:1935-1943.
18. Xu HHK, Quinn JB, Takagi S, Chow LC, Eichmiller FC. Strong and macroporous calcium phosphate cement: Effects of porosity and fiber reinforcement on mechanical properties. J Biomed Mater Res 2001;57:457-466.
19. Xu HHK, Quinn JB, Takagi S, Chow LC. Synergistic reinforcement of in situ hardening calcium phosphate composite scaffold for bone tissue engineering. Biomaterials 2004;25:1029-1037.
20. Xu HHK, Simon CG Jr. Self-hardening calcium phosphate cement-mesh composite: Reinforcement, macropores, and cell response. J Biomed Mater Res 2004;69A:267-278.
21. Simon CG Jr, Guthrie WF, Wang FW. Cell seeding into calcium phosphate cement. J Biomed Mater Res A 2004;68:628-639.
22. Muzzarelli RA, Biagini G, Bellardini M, Simonelli L, Castaldini C, Fratto G. Osteoconduction exerted by methylpyrrolidinone chitosan used in dental surgery. Biomaterials 1993;14:39-43.
23. Xu HHK, Quinn JB, Takagi S, Chow LC. Processing and properties of strong and non-rigid calcium phosphate cement. J Dent Res 2002;81:219-224.
24. Klokk TI, Melvik JE. Controlling the size of alginate gel beads by use of a high electrostatic potential. J Microencapsul 2002;19:415-424.
25. Koch S, Schwinger C, Kressler J, Heinzen C, Rainov NG. Alginate encapsulation of genetically engineered mammalian cells: Comparison of production devices, methods and microcapsule characteristics. J Microencapsul 2003;20:303-316.
26. Carey LE, Xu HHK, Simon CG Jr, Takagi S, Chow LC. Premixed rapid-setting calcium phosphate composites for bone repair. Biomaterials 2005;26:5002-5014.
27. Xu HH, Eichmiller FC, Giuseppetti AA. Reinforcement of a self-setting calcium phosphate cement with different fibers. J Biomed Mater Res 2000;52:107-114.
28. 4. J Mater Sci Mater Med 2000;11:305-311.
29. Lee KY, Alsberg E, Mooney DJ. Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering. J Biomed Mater Res 2001;56:228-233.
30. Boontheekul T, Kong HJ, Mooney DJ. Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials 2005;26:2455-2465.
31. Payne RG, Yaszemski MJ, Yasko AW, Mikos AG. Development of an injectable, in situ crosslinkable, degradable polymeric carrier for osteogenic cell populations. Part 1. Encapsulation of marrow stromal osteoblasts in surface crosslinked gelatin microparticles. Biomaterials 2002;23:4359-4371.
32. Li S, Molina I, Martinez MB, Vert M. Hydrolytic and enzymatic degradations of physically crosslinked hydrogels prepared from PLA/PEO/PLA triblock copolymers. J Mater Sci Mater Med 2002;13:81-86.
33. Kim BS, Hrkach JS, Langer R. Synthesis and characterization of novel degradable photocrosslinked poly(ether-anhydride) networks. J Polym Sci Part A: Polym Chem 2000;38:1277-1282.
34. Xu HHK, Wei L, Padture NP, Lawn BR, Yeckley RL. Microstructural coarsening effect on hertzian contact damage in silicon nitride. J Mater Sci 1995;30:869-878.
35. Livingston T, Ducheyne P, Garino J. In vivo evaluation of a bioactive scaffold for bone tissue engineering. J Biomed Mater Res 2002;62:1-13.
36. Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res 1998;13:94-117.
37. Damien CJ, Parsons JR. Bone graft and bone graft substitutes: A review of current technology and applications. J Appl Biomater 1991;2:187-208.
38. Bruder SP, Jaiswal N, Ricalton NS, Mosa JD, Kraus KH, Kadiyala S. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop 1998;355:S247-S256.