The Igd CH1 region contains the binding site for the human respiratory pathogen Moraxella catarrhalis IgD-binding protein MID

European Journal of Immunology

Volumn 36, Issue 9, 2006, Pages 2525-2534

  Samuelsson, Martin ^a   Jendholm, Johan ^a   Amisten, Stefan ^a   Morrison, Sherie L ^b   Forsgren, Arne ^a   Riesbeck, Kristian ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Binding; Immunoglobulin D; Moraxella catarrhalis

Indexed keywords

BINDING PROTEIN; IMMUNOGLOBULIN D; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; MORAXELLA CATARRHALIS IMMUNOGLOBULIN D BINDING PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ADHESIN; IGD BINDING PROTEIN MID, MORAXELLA CATARRHALIS; IGD-BINDING PROTEIN MID, MORAXELLA CATARRHALIS; IMMUNOGLOBULIN HEAVY CHAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY STRUCTURE; ARTICLE; BACTERIAL IMMUNITY; BACTERIUM MUTANT; BINDING KINETICS; BINDING SITE; CHIMERA; CONTROLLED STUDY; DOT HYBRIDIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; MORAXELLA CATARRHALIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; ANIMAL; ANTIBODY COMBINING SITE; CHEMISTRY; CHO CELL; CRICETULUS; GENETICS; HAMSTER; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS;

ADHESINS, BACTERIAL; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES, ANTIBODY; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAINS; MOLECULAR SEQUENCE DATA; MORAXELLA (BRANHAMELLA) CATARRHALIS; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 33748857116     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535594     Document Type: Article

References (29)

1. Catlin, B. W., Branhamella catarrhalis: An organism gaining respect as a pathogen. Clin. Microbiol. Rev. 1990. 3: 293-320.
2. Murphy, T. F., Branhamella catarrhalis: Epidemiology, surface antigenic structure, and immune response. Microbiol. Rev. 1996. 60: 267-279.
3. Karalus, R. and Campagnari, A., Moraxella catarrhalis: A review of an important human mucosal pathogen. Microbes. Infect. 2000. 2: 547-559.
4. El-Ahmer, O. R., Braun, J. M., Amyes, S. G., Weir, D. M., Beuth, J. and Blackwell, C. C., Comparison of Moraxella catarrhalis isolates from children and adults for growth on modified New York City medium and potential virulence factors. J. Med. Microbial. 2003. 52: 853-859.
5. Leung, A. K. and Kellner, J. D., Acute sinusitis in children: Diagnosis and management. J. Pediatr Health Care 2004. 18: 72-76.
6. Forsgren, A. and Grubb, A. O., Many bacterial species bind human IgD. J. Immunol. 1979. 122: 1468-1472.
7. Calvert, J. E. and Calogeras, A., Characteristics of human B cells responsive to the T-independent mitogen Branhamella catarrhalis. Immunology 1986. 8: 37-41.
8. Forsgren, A., Penta, A., Schlossman, S. F. and Tedder, T. F., Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. Cell. Immunol. 1988. 112: 78-88.
9. Huston, M. M., Moore, J. P., Mertes, H. J., Tavana, G. and Huston, D. P., Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. J. Immunol. 1996. 156: 1392-1401.
10. GjorloffWingren, A., Hadzic, R., Forsgren, A. and Riesbeck K., The novel IgD binding protein from Moraxella catarrhalis induces human B lymphocyte activation and Ig secretion in the presence of Th2 cytokines. J. Immunol. 2002. 168: 5582-5588.
11. Nordstrom, T., Jendholm, J., Samuelsson, M., Forsgren, A. and Riesbeck, K., The IgD-binding domain of the Moraxella IgD-binding protein MID (MID962-1200) activates human B cells in the presence of T cell cytokines. J. Leukoc. Biol. 200S
12. Forsgren, A., Brant, M., Mollenkvist, A., Muyombwe, A., Janson, H., Woin, N. and Riesbeck, K., Isolation and characterization of a novel IgD-binding protein from Moraxella catarrhalis. J. Immunol. 2001. 167: 2112-2120.
13. Fitzgerald, M., Mulcahy, R., Murphy, S., Keane, C., Coakley, D. and Scott, T., A 200 kDa protein is associated with haemagglutinating isolates of Moraxella (Branhamella) catarrhalis. FEMS Immunol. Med. Microbiol. 1997 18: 209-216.
14. Pearson, M. M., Lafontaine, E. R., Wagner, N. J., St Geme, J. W., 3rd and Hansen, E. J., A hag mutant of Moraxella catarrhalis strain O35E is deficient in hemagglutination, autoagglutination, and immunoglobulin D-binding activities. Infect. Immun. 2002. 70: 4523-4533.
15. Mollenkvist, A., Nordstrom, T., Hallden, C., Christensen, J. J., Forsgren, A. and Riesbeck, K., The Moraxella catarrhalis immunoglobulin D-binding protein MID has conserved sequences and is regulated by a mechanism corresponding to phase variation. J. Bacterial. 2003. 185: 2285-2295.
16. Nordstrom, T., Forsgren, A. and Riesbeck, K., The immunoglobulin D-binding part of the outer membrane protein MID from Moraxella catarrhalis comprises 238 amino acids and a tetrameric structure. J. Biol. Chem. 2002. 277: 34692-34699.
17. Clark, E. A. and Ledbetter, J. A., Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc. Natl. Acad. Sci. USA 1986. 83: 4494-4498.
18. Nitschke, L., Kosco, M. H., Kohler, G. and Lamers, M. C., Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens. Proc. Nad. Acad. Sci. USA 1993. 90: 1887-1891.
19. Lutz, C., Ledermann, B., Kosco-Vilbois, M. H., Ochsenbein, A. F., Zinkernagel, R. M., Kohler, G. and Brombacher, F., IgD can largely substitute for loss of IgM function in B cells. Nature 1998. 393: 797-801.
20. Sun, Z., Almogren, A., Furtado, P. B., Chowdhury, B., Kerr, M. A. and Perkins, S. J., Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering. J. Mol. Biol. 2005. 353: 155-173.
21. Graille, M., Stura, E. A., Corper, A. L., Sutton, B. J., Taussig, M. J., Charbonnier, J. B. and Silverman, G. J., Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity. Proc. Nad. Acad. Sci. USA 2000. 97: 5399-5404.
22. H-targeted apoptotic supraclonal B cell deletion by a staphylococcal toxin. J. Exp. Med. 2003. 197: 1125-1139.
23. Thiele, C. J., Owens, J. D., Finkelman, F. D. and Mushinski, J. F., Mouse IgD half molecules with shortened IgD heavy chain result from alterations within C delta locus. J. Immunol. 1985. 134: 1251-1256.
24. Derrick, J. P. and Wigley, D. B., The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab. J. Mal. Biol. 1994. 243: 906-918.
25. Forsgren, A., Brant, M., Karamehmedovic, M. and Riesbeck, K., The immunoglobulin D-binding protein MID from Moraxella catarrhalis is also an adhesin. Infect. Immun. 2003. 71: 3302-3309.
26. Holm, M. M., Vanlerberg, S. L., Sledjeski, D. D. and Lafontaine, E. R., The Hag protein of Moraxella catarrhalis strain O35E is associated with adherence to human lung and middle ear cells. Infect. Immun. 2003. 71: 4977-4984.
27. Forsgren, A., Brant, M. and Riesbeck, K., Immunization with the truncated adhesin Moraxella catarrhalis immunoglobulin D-binding protein (MID764-913) is protective against M. catarrhalis in a mouse model of pulmonary clearance. J. Infect. Dis. 2004. 190: 352-355.
28. Shin, S. U., Wei, C. F., Amin, A. R., Thorbecke, G. J. and Morrison, S. L., Structural and functional properties of mouse-human chimeric IgD. Hum. Antibodies Hybridomas 1992. 3: 65-74.
29. H2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1. J. Exp. Med. 1994. 180: 1087-1096.