DNA-DNA cross-links contribute to the mutagenic potential of the mycotoxin patulin

Toxicology Letters

Volumn 166, Issue 3, 2006, Pages 268-275

  Schumacher, David M ^a   Müller, Carolin ^a   Metzler, Manfred ^a   Lehmann, Leane ^a  

^a UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

DNA strand breaks; DNA DNA cross links; Fpg; Oxidative DNA base modifications; Patulin; V79 cells

Indexed keywords

PATULIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DNA BINDING; DNA MODIFICATION; EVALUATION; GENE MUTATION; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CRICETINAE; CROSS-LINKING REAGENTS; DNA; DNA FRAGMENTATION; ETHIDIUM; FIBROBLASTS; FLUORESCENT DYES; MUTAGENS; OXIDATION-REDUCTION; PATULIN;

MAMMALIA;

EID: 33748802756     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.08.002     Document Type: Article

References (36)

1. Alves I., Oliveira N.G., Laires A., Rodrigues A.S., and Rueff J. Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: role of ascorbic acid as a modulator of patulin clastogenicity. Mutagenesis 15 (2000) 229-234
2. Batel R., Vukmirovic M., Bihari N., Zahn R.K., and Muller W.E. Nonradiometric detection of DNA crosslinks in mussel hemolymph by alkaline elution. Anal. Biochem. 212 (1993) 402-406
3. Becci P.J., Hess F.G., Johnson W.D., Gallo M.A., Babish J.G., Dailey R.E., and Parent R.A. Long-term carcinogenicity and toxicity studies of patulin in the rat. J. Appl. Toxicol. 1 (1981) 256-261
4. Boiteux S., O'Connor T.R., Lederer F., Gouyette A., and Laval J. Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites. J. Biol. Chem. 265 (1990) 3916-3922
5. de Jong S., Zijlstra J.G., Timmer-Bosscha H., Mulder N.H., and de Vries E.G. Detection of DNA cross-links in tumor cells with the ethidium bromide fluorescence assay. Int. J. Cancer 37 (1986) 557-561
6. Dickens F., and Jones H.E. Carcinogenic activity of a series of reactive lactones and related substances. Br. J. Cancer 15 (1961) 85-100
7. Epe B., and Hegler J. Oxidative DNA damage: endonuclease fingerprinting. Meth. Enzymol. 234 (1994) 122-131
8. Fliege, R. 1999. Zum molekularen Wirkmechanismus des Mykotoxins Patulin: Charakterisierung der spontanen Reaktivität gegenüber nucleophilen Modellsubstanzen und biologischen Makromolekülen in, vitro., Ph.D., Thesis, University of Karlsruhe (TH), Germany, pp., 84-87.
9. Fliege R., and Metzler M. The mycotoxin patulin induces intra- and intermolecular protein crosslinks in vitro involving cysteine, lysine, and histidine side chains, and alpha-amino groups. Chem. Biol. Interact. (1999) 123
10. Fliege R., and Metzler M. Electrophilic properties of patulin. N-acetylcysteine and glutathione adducts. Chem. Res. Toxicol. 13 (2000) 373-381
11. Fliege R., and Metzler M. Electrophilic properties of patulin. Adduct structures and reaction pathways with 4-bromothiophenol and other model nucleophiles. Chem. Res. Toxicol. 13 (2000) 363-372
12. Ford D.K., and Yerganian G. Observations on the chromosomes of Chinese hamster cells in tissue culture. J. Nat. Cancer Inst. 21 (1958) 393-425
13. Garberg P., Akerblom E.L., and Bolcsfoldi G. Evaluation of a genotoxicity test measuring DNA-strand breaks in mouse lymphoma cells by alkaline unwinding and hydroxyapatite elution. Mutat. Res. 203 (1988) 155-176
14. IARC, 1986. Some Naturally Occurring and Synthetic Food Components, Furocoumarins and Ultraviolet Radiation. In: (Eds.), Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC, Lyon, pp. 83-98.
15. Kohn K.W., Erickson L.C., Ewig R.A., and Friedman C.A. Fractionation of DNA from mammalian cells by alkaline elution. Biochemistry 15 (1976) 4629-4637
16. Kohn K.W. Principles and practice of DNA filter elution. Pharmacol. Ther. 49 (1991) 55-77
17. Lai C.-L., Fuh Y.-M., and Shih D.Y.-C. Detection of mycotoxin patulin in apple juice. Yaowu Shipin Fenxi 8 (2000) 85-96
18. Liu B.H., Yu F.Y., Wu T.S., Li S.Y., Su M.C., Wang M.C., and Shih S.M. Evaluation of genotoxic risk and oxidative DNA damage in mammalian cells exposed to mycotoxins, patulin and citrinin. Toxicol. Appl. Pharmacol. 191 (2003) 255-263
19. Madle S., Beek B., and Nowak C. Zum Verständnis von Chromosomenmutationstests an Somazellen. In: Fahrig R. (Ed). Mutationsforschung und genetische Toxikologie (1993), Wissenschaftliche Buchgesellschaft, Darmstadt 224-242
20. Merk O., and Speit G. Detection of crosslinks with the comet assay in relationship to genotoxicity and cytotoxicity. Environ. Mol. Mutagen. 33 (1999) 167-172
21. Osswald H., Frank H.K., Komitowski D., and Winter H. Long-term testing of patulin administered orally to Sprague-Dawley rats and Swiss mice. Food Cosmet. Toxicol. 16 (1978) 243-247
22. Pfeiffer E., Gross K., and Metzler M. Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. Carcinogenesis 19 (1998) 1313-1318
23. Pflaum M., Will O., and Epe B. Determination of steady-state levels of oxidative DNA base modifications in mammalian cells by means of repair endonucleases. Carcinogenesis 18 (1997) 2225-2231
24. Pflaum M., Kielbassa C., Garmyn M., and Epe B. Oxidative DNA damage induced by visible light in mammalian cells: extent, inhibition by antioxidants and genotoxic effects. Mutat. Res. 408 (1998) 137-146
25. Pflaum M., and Epe B. Measuring oxidative DNA damage by alkaline elution. In: Lunec J., and Griffiths H. (Eds). Measuring in vivo Oxidative Damage: a Practical Approach (2000), John Wiley & Sons, Chichester, New York, Weinheim, Brisbane, Toronto, Singapore 95-104
26. Piemontese L., Solfrizzo M., and Visconti A. Occurrence of patulin in conventional and organic fruit products in Italy and subsequent exposure assessment. Food Addit. Contam. 22 (2005) 437-442
27. Sasaki Y.F., Sekihashi K., Izumiyama F., Nishidate E., Saga A., Ishida K., and Tsuda S. The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and US. NTP carcinogenicity database. Crit. Rev. Toxicol. 30 (2000) 629-799
28. Schumacher D.M., Metzler M., and Lehmann L. Mutagenicity of the mycotoxin patulin in cultured Chinese hamster V79 cells, and its modulation by intracellular glutathione. Arch. Toxicol. 79 (2005) 110-121
29. Schumacher D.M., Wagner J., Metzler M., and Lehmann L. Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells. Mycotoxin Res. 21 (2005) 150-152
30. Sina J.F., Bean C.L., Dysart G.R., Taylor V.I., and Bradley M.O. Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential. Mutat. Res. 113 (1983) 357-391
31. Sognier M.A., and Hittelman W.N. Mitomycin-induced chromatid breaks in HeLa cells: a consequence of incomplete DNA replication. Cancer Res. 46 (1986) 4032-4040
32. Stetina R., and Votava M. Induction of DNA single-strand breaks and DNA synthesis inhibition by patulin, ochratoxin A, citrinin, and aflatoxin B1 in cell lines CHO and AWRF. Folia Biol. 32 (1986) 128-144
33. Storer R.D., McKelvey T.W., Kraynak A.R., Elia M.C., Barnum J.E., Harmon L.S., Nichols W.W., and DeLuca J.G. Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds. Mutat. Res. 368 (1996) 59-101
34. Umeda M., Yamamoto T., and Saito M. DNA-strand breakage of HeLa cells induced by several mycotoxins. Jpn. J. Exp. Med. 42 (1972) 527-535
35. Umeda M., Tsutsui T., and Saito M. Mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations by various mycotoxins. Gann 68 (1977) 619-625
36. Watanabe M., and Shimizu H. Detection of patulin in apple juices marketed in the Tohoku district. Jpn. J. Food Prot. 68 (2005) 610-612