Potent inhibition of the CD4-dependent T cell response by J2, a novel nonpeptide organic ligand of CD4 D1

Molecular Immunology

Volumn 44, Issue 5, 2007, Pages 784-795

  Xiao, He ^a   Feng, Jian Nan ^a   He, Xin hua ^b   Zhang, Han ^c   Zhang, Jing Rui ^a   Zhang, Lei ^c   Yu, Ming ^a   Huang, Yi Fei ^c   Li, Song ^b   Shen, Bei Fen ^a   Li, Yan ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

CD4 D1; CD4 MHC II interaction; CD4+ T cell response; Immunosuppressive agents; Non peptidic small molecular organic inhibitors; Rosette formation

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CD4+ T LYMPHOCYTE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CYTOKINE RELEASE; DATA BASE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ACRYLAMIDES; ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL PROLIFERATION; DRUG DESIGN; EPITOPES, T-LYMPHOCYTE; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSUPPRESSIVE AGENTS; INDOLES; INTERLEUKIN-2; LIGANDS; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED C57BL; SKIN TRANSPLANTATION;

EID: 33748787416     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.04.018     Document Type: Article

References (48)

1. lck) that phophorylates the CD3 complex. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 3277-3281
2. Billingham R.E., and Medawar P.B. The technique of free skin grafting in mammals. J. Exp. Biol. 28 (1951) 385-402
3. Clayton L.K., Sieh M., Pious D.A., and Reinherz E.L. Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Nature (London) 339 (1989) 548-551
4. Doyle C., and Strominger J.L. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330 (1987) 256-259
5. Edling A.E., Choksi S., Huang Z., and Korngold R. An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. J. Autoimmun. 18 (2002) 169-179
6. Fleury S., Lamarre D., Meloche S., Ryu S.E., Cantin C., Hendrickson W.A., and Sekaly R.P. Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site. Cell 66 (1991) 1037-1049
7. + T cell function. J. Biol. Chem. 271 (1996) 22635-22640
8. Gay D., Maddon P., Sekaly R., Talle M.A., Godfrey M., Long E., Goldstein G., Chess L., Axel R., Kappler J., and Marrack P. Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature 328 (1987) 626-629
9. Hafler D.A., and Weiner H.L. T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunol. Rev. 100 (1987) 307-332
10. Huang Z., Li S., and Korngold R. Immunoglobulin superfamily proteins: structure, mechanisms, and drug discovery. Biopolymers 43 (1997) 367-382
11. Jameson B.A., McDonnell J.M., Marini J.C., and Korngold R. A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis. Nature 368 (1994) 744-746
12. Janeway Jr. C.A. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10 (1992) 645-674
13. Knulst A.C., Tibbe G.J., Noort W.A., Bril-Bazuin C., Benner R., and Savelkoul H.F. Prevention of lethal graft-versus-host disease in mice by monoclonal antibodies directed against T cells or their subsets. I. Evidence for the induction of a state of tolerance based on suppression. Bone Marrow Transplant. 13 (1994) 293-301
14. Koch U., and Korngold R. A synthetic CD4-CDR3 peptide analog enhances bone marrow engraftment across major histocompatibility barriers. Blood 89 (1997) 2880-2890
15. Konig R., Huang L.Y., and Germain R.N. MHC class II interaction with CD4 mediated by a region analogous to the MHC class binding site for CD8. Nature 356 (1992) 796-798
16. Korngold R., and Sprent J. Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences. J. Immunol. 135 (1985) 3004-3010
17. Korngold R., and Sprent J. Purified T Cell Subsets and Lethal Graft-Versus-Host Disease in Mice (1987), Alan R. Liss, New York pp. 213-218
18. Lamarre D., Ashkenazi A., Fleury S., Smith D.H., Sekaly R.P., and Capon D.J. The MHC-binding and gp120-binding functions of CD4 are separable. Science 245 (1989) 743-746
19. Lange G., Lewis S.J., Murshudov G.N., Dodson G.G., Moody P.C., Turkenburg J.P., Barclay A.N., and Brady R.L. Crystal structure of an extracellular fragment of the rat CD4 receptor containing domains 3 and 4. Structure (Lond.) 2 (1994) 469-481
20. Lechler R.I., Lombardi G., Batchelor J.R., Reinsmoen N., and Bach F.H. The molecular basis of alloreactivity. Immunol. Today 11 (1990) 83-88
21. Li S., Gao J., Satoh T., Friedman T., Edling A., Koch U., Choksi S., Han X., Korngold R., and Huang Z. A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 73-78
22. Lindsey J.W., Hodgkinson S., Mehta R., Mitchell D., Enzmann D., and Steinman L. Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis. Ann. Neurol. 36 (1994) 183-189
23. Lucas B.A., Waid T., Thompson J.S., Brown S.A., Munch L.C., McKeown J.W., Kryscio R.J., and Prebeck R.J. Comparison of T10Bg.lA-31 and OKT3 in treating acute renal allograft rejection. Transplant. Proc. 25 (1993) 543-545
24. Maddon P.J., Littman D.R., Godfrey M., Maddon D.E., Chess L., and Axel R. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42 (1985) 93-104
25. McDonnell J.M., Blank K.J., Rao P.E., and Jameson B.A. Direct involvement of the CDR3-like domain of CD4 in T helper cell activation. J. Immunol. 149 (1992) 1626-1630
26. McDonnell J.M., Varnum J.M., Mayo K.H., and Jameson B.A. Rational design of a peptide analog of the L3T4 CDR3-like region. Immunomethods 1 (1992) 33-39
27. Miceli M.C., and Parnes J.R. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53 (1993) 59-122
28. Moebius U., Clayton L.K., Abraham S., Diener A., Yunis J.J., Harrison S.C., and Reinherz E.L. Human immunodeficiency virus gp120 binding C′C′′ ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 12008-12012
29. Moebius U., Pallai P., Harrison S.C., and Reinherz E.L. Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 8259-8263
30. Morel P., Vincent C., Cordier G., Panaye G., Carosella E., and Revillard J.P. Anti-CD4 monoclonal antibody administration in renal transplanted patients. Clin. Immunol. Immunopathol. 56 (1990) 311-322
31. 8) antibodies prevent graft-versus-host disease in fully mismatched mice. Transplantation 57 (1994) 458-461
32. Reinherz E.L., Kung P.C., Goldstein G., and Schlossman S.F. Separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. U.S.A. 76 (1979) 4061-4065
33. Reinherz E.L., Kung P.C., Goldstein G., Levey R.H., and Schlossman S.F. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc. Natl. Acad. Sci. U.S.A. 77 (1980) 1588-1592
34. Reinke P., Volk H., Miller H., Neuhaus K., Fietze E., Herberger J., Herberger D., von Baehr R., and Emmrich F. Anti-CD4 therapy of acute rejection in long-term renal allograft recipients. Lancet 338 (1991) 702-703
35. Ryu S.E., Kwong P.D., Truneh A., Porter T.G., Arthos J., Rosenberg M., Dai X., Xuong N., Axel R., Sweet R.W., and Hendrickson W.A. Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature 348 (1990) 419-426
36. Satoh T., Aramini J.M., Li S., Friedman T.M., Gao J., Edling A., Townsend R., Germann M.W., Korngold R., and Huang Z. Bioactive peptide design based on protein surface epitopes. A cyclic heptapeptide mimics CD4 domain 1 CC′ loop and inhibits CD4 biological function. J. Biol. Chem. 272 (1997) 12175-12180
37. Sigal N.H., Dumont F., Durette P., Siekierka J.J., Peterson L., Rich D.H., Dunlap B.E., Staruch M.J., Melino M.R., and Koprak S.L. Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?. J. Exp. Med. 173 (1991) 619-628
38. Swain S.L. T cell subsets and the recognition of MHC class. Immunol. Rev. 74 (1983) 129-142
39. Townsend R.M., Briggs C., Marini J.C., Murphy G.F., and Korngold R. Inhibitory effect of a CD4-CDR3 peptide analog on graft-vs-host disease across a MHC-haploidentical barrier. Blood 88 (1996) 3038-3047
40. Traugott U., Reinherz E.L., and Raine C.S. Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science 219 (1983) 308-310
41. lck. Cell 55 (1988) 301-308
42. Via C.S., Tsokos G.C., Stocks N.I., Clerici M., and Shearer G.M. Human in vitroallogeneic responses: demonstration of three pathways of T helper cell activation. J. Immunol. 144 (1990) 2524-2528
43. Wallace A.C., Laskowski R.A., and Thornton J.M. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng. 8 (1995) 127-134
44. Wang J., Yan Y., Garrett T.P.J., Liu J., Rodgers D.W., Garlick R.L., Tarr G.E., Husain Y., Reinherz E.L., and Harrison S.C. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 348 (1990) 411-418
45. White R.A.H., Mason D.W., Williams A.F., Galfre G., and Milstein C. T-lymphocyte heterogeneity in the rat: separation of functional subpopulations using a monoclonal antibody. J. Exp. Med. 148 (1978) 664-673
46. Wong J.T., Eylath A.A., Ghobrial I., and Colvin R.B. The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging. Transplantation 45 (1990) 683-689
47. Wu H., Kwong P.D., and Hendrickson W.A. Dimeric association and segmental variability in the structure of human CD4. Nature (London) 387 (1997) 527-530
48. Zhang X., Piatier-Tonneau D., Auffray C., Murali R., Mahapatra A., Zhang F., Maier C.C., Saragovi H., and Greene M.I. Synthetic CD4 exocyclics inhibit binding of human immunodeficiency virus type 1 envelope to CD4 and virus replication in T lymphocytes. Nat. Biotechnol. 14 (1996) 472-475