Amyloid-β vaccination: Testing the amyloid hypothesis? Heads we win, tails you lose!

American Journal of Pathology

Volumn 169, Issue 3, 2006, Pages 738-739

  Lee, Hyoung Gon ^a   Zhu, Xiongwei ^a   Nunomura, Akihiko ^b   Perry, George ^a,c   Smith, Mark A ^a,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c University of San Antonio   (United States)

^d Department of Pathology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; VACCINE;

ALZHEIMER DISEASE; CLINICAL RESEARCH; CLINICAL TRIAL; EXPERIMENTAL MODEL; HUMAN; HYPOTHESIS; NERVE DEGENERATION; NONHUMAN; NOTE; PRIORITY JOURNAL; SENILE PLAQUE; VACCINATION;

EID: 33748786533     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.060633     Document Type: Note

References (16)

1. Hardy JA, Higgins GA: Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256:184-185
2. Lorenzo A, Yankner BA: Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 1994, 91:12243-12247
3. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G: Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102
4. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guide T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P: Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400:173-177
5. Buttini M, Masliah E, Barbour R, Grajeda H, Motter R, Johnson-Wood K, Khan K, Seubert P, Freedman S, Schenk D, Games D: Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J Neurosci 2005, 25:9096-9101
6. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356
7. Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH: A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006, 440:352-357
8. Birmingham K, Frantz S: Set back to Alzheimer vaccine studies. Nat Med 2002, 8:199-200
9. Patton RL, Kalback WM, Esh CL, Kokjohn TA, Van Vickle GD, Luehrs DC, Kuo Y-M, Lopez J, Brune D, Ferrer I, Masliah E, Newel AJ, Beach TG, Castano EM, Roher AE: Abeta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am J Pathol 2006, 169:1048-1063
10. Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, Muller-Tillmanns B, Lemke U, Henke K, Moritz E, Garcia E, Wollmer MA, Umbricht D, de Quervain DJ, Hofmann M, Maddalena A, Papassotiropoulos A, Nitsch RM: Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003, 38:547-554
11. Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Rovira MB, Forette F, Orgogozo JM: Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005, 64:1553-1562
12. Perry G, Nunomura A, Raina AK, Smith MA: Amyloid-beta junkies. Lancet 2000, 355:757
13. Smith MA, Atwood CS, Joseph JA, Perry G: Predicting the failure of amyloid-beta vaccine. Lancet 2002, 359:1864-1865
14. Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA: Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Ann NY Acad Sci 2004, 1019:1-4
15. Rottkamp CA, Atwood CS, Joseph JA, Nunomura A, Perry G, Smith MA: The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease. Peptides 2002, 23:1333-1341
16. Lee HG, Zhu X, Nunomura A, Perry G, Smith MA: Amyloid beta: the alternate hypothesis. Curr Alzheimer Res 2006, 3:75-80