A convenient synthesis of 1,4-disubstituted isoquinolines by reactions of α-substituted 2-lithio-β-methoxystyrenes with nitriles

Synthesis

Volumn , Issue 17, 2006, Pages 2934-2938

  Kobayashi, Kazuhiro ^a   Hayashi, Kazutaka ^a   Miyamoto, Kazuna ^a   Morikawa, Osamu ^a   Konishi, Hisatoshi ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Benzyl anion; Isoquinoline; Nitrile; Organolithium; Styrene

Indexed keywords

HALOGEN COMPOUNDS; HYDROCARBONS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

BENZYL ANION; ISOQUINOLINE; ORGANOLITHIUM;

NITROGEN COMPOUNDS;

1 (1 METHYLETHYL) 4 PHENYLISOQUINOLINE; 1 (1,1 DIMETHYLETHYL) 6 METHOXY 4 PHENYLISOQUINOLINE; 1 (2 FLUOROPHENYL) 4 PHENYLISOQUINOLINE; 1 (2 METHYLPHENYL 4 PHENYLISOQUINOLINE); 1 (4 CHLOROPHENYL) 4 PHENYLISOQUINOLINE; 1 (4 CHLOROPHENYL) 6 METHOXY 4 PHENYLISOQUINOLINE; 1 (NAPHTHALEN 1 YL) 4 PHENYLISOQUINOLINE; 1 CYCLOHEXYL 4 PHENYLISOQUINOLINE; 1,4 DIPHENYLISOQUINOLINE; 4 (4 CHLOROPHENYL) 1 ETHYLISOQUINOLINE; 4 (4 CHLOROPHENYL) 1 PHENYLISOQUINOLINE; 4 METHYL 1 PHENYLISOQUINOLINE; 4 PHENYL 1 (2 PHENYLVINYL)ISOQUINOLINE; 4 PHENYL 1 (4 TRIFLUOROMETHYLPHENYL)ISOQUINOLINE; 4 PHENYL 1 (PYRIDIN 2 YL)ISOQUINOLINE; 6 METHOXY 1,4 DIPHENYLISOQUINOLINE; 6 METHOXY 4 PHENYL 1 (4 TRIFLUOROMETHYLPHENYL)ISOQUINOLINE; ISOQUINOLINE DERIVATIVE; NITRILE; STYRENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; MELTING POINT; SPECTROMETER;

EID: 33748784648     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-950186     Document Type: Article

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