Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1

FEBS Letters

Volumn 580, Issue 22, 2006, Pages 5203-5207

  Yoshida, Tomohiko ^a   Asanuma, Mie ^a   Grossmann, Laura ^a   Fuse, Masami ^a   Shibata, Takahisa ^a   Yonekawa, Taeko ^a   Tanaka, Tomoaki ^a   Ueno, Koichi ^a   Yasuda, Tatsuji ^b   Saito, Yasushi ^a   Tatsuno, Ichiro ^a  

^a CHIBA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Differentiation; GGPP; GGPP synthase; Osteoblast; Proliferation

Indexed keywords

FARNESYL TRANS TRANSFERASE; GERANYLGERANIOL;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL ADHESION; CELL DIFFERENTIATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; INHIBITION KINETICS; ISOPRENYLATION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINE; DOWN-REGULATION; ENZYME ACTIVATION; FARNESYLTRANSTRANSFERASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MONOMERIC GTP-BINDING PROTEINS; MULTIENZYME COMPLEXES; OSTEOBLASTS; RNA, MESSENGER;

EID: 33748776041     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.08.060     Document Type: Article

References (33)

1. Casey P.J., and Seabra M.C. Protein prenyltransferases. J. Biol. Chem. 271 (1996) 5289-5292
2. Chakrabarti R., and Engleman E.G. Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. J. Biol. Chem. 266 (1991) 12216-12222
3. Ortiz M.B., Goin M., Gomez D.A.M.B., Hammarstrom S., and Jimenez D.A.L. Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2 alpha in Swiss mouse 3T3 cells. J. Cell Physiol. 162 (1995) 139-146
4. Tanaka T., Tatsuno I., Uchida D., Moroo I., Morio H., Nakamura S., Noguchi Y., Yasuda T., Kitagawa M., Saito Y., and Hirai A. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J. Neurosci. 20 (2000) 2852-2859
5. Tanaka T., Tatsuno I., Noguchi Y., Uchida D., Oeda T., Narumiya S., Yasuda T., Higashi H., Kitagawa M., Nakayama K., Saito Y., and Hirai A. Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. J. Biol. Chem. 273 (1998) 26772-26778
6. Hirai A., Nakamura S., Noguchi Y., Yasuda T., Kitagawa M., Tatsuno I., Oeda T., Tahara K., Terano T., Narumiya S., Kohn L.D., and Saito Y. Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J. Biol. Chem. 272 (1997) 13-16
7. Nakamura S., Tatuno I., Noguchi Y., Kitagawa M., Kohn L.D., Saito Y., and Hirai A. 73-kDa heat shock cognate protein interacts directly with P27Kip1, a cyclin-dependent kinase inhibitor, during G1/S transition. Biochem. Biophys. Res. Commun. 257 (1999) 340-343
8. Noguchi Y., Nakamura S., Yasuda T., Kitagawa M., Kohn L.D., Saito Y., and Hirai A. Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells. J. Biol. Chem. 273 (1998) 3649-3653
9. Terano T., Shiina T., Noguchi Y., Tanaka T., Tatsuno I., Saito Y., Yasuda T., Kitagawa M., and Hirai A. Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells. J. Atheroscler. Thromb. 5 (1998) 1-6
10. Nishimura M., Tanaka T., Yasuda T., Kurakata S., Kitagawa M., Yamada K., Saito Y., and Hirai A. Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate. Kidney Int. 55 (1999) 520-528
11. Tatsuno I., Tanaka T., Oeda T., Yasuda T., Kitagawa M., Saito Y., and Hirai A. Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes. Biochem. Biophys. Res. Commun. 241 (1997) 376-382
12. Duong L.T., and Rodan G.A. Regulation of osteoclast formation and function. Rev. Endocr. Metab. Disord. 2 (2001) 95-104
13. Aubin J.E. Regulation of osteoblast formation and function. Rev. Endocr. Metab. Disord. 2 (2001) 81-94
14. Katagiri T., and Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Diseases 8 (2002) 147-159
15. Luckman S.P., Hughes D.E., Coxon F.P., Graham R., Russell G., and Rogers M.J. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J. Bone Miner. Res. 13 (1998) 581-589
16. Fisher J.E., Rogers M.J., Halasy J.M., Luckman S.P., Hughes D.E., Masarachia P.J., Wesolowski G., Russell R.G., Rodan G.A., and Reszka A.A. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc. Natl. Acad. Sci. USA 96 (1999) 133-138
17. Sugiyama M., Kodama T., Konishi K., Abe K., Asami S., and Oikawa S. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem. Biophys. Res. Commun. 271 (2000) 688-692
18. Pan B., To L.B., Farrugia A.N., Findlay D.M., Green J., Gronthos S., Evdokiou A., Lynch K., Atkins G.J., and Zannettino A.C. The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone 34 (2004) 112-123
19. Ohnaka K., Shimoda S., Nawata H., Shimokawa H., Kaibuchi K., Iwamoto Y., and Takayanagi R. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem. Biophys. Res. Commun. 287 (2001) 337-342
20. Ericsson J., Greene J.M., Carter K.C., Shell B.K., Duan D.R., Florence C., and Edwards P.A. Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression. J. Lipid Res. 39 (1998) 1731-1749
21. Kuzuguchi T., Morita Y., Sagami I., Sagami H., and Ogura K. Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. J. Biol. Chem. 274 (1999) 5888-5894
22. Misawa N., Okazaki H., Noguchi Y., Tatsuno I., Saito Y., Yasuda T., and Hirai A. Study on isolation of a geranylgeranyl pyrophosphate (GGPP) synthase cDNA and its expression - development of a new assay system of gene functions. Proc. Jpn. Conf. Biochem. Lipids 41 (1999) 293-296
23. Fuse M., Tanaka T., SHibata T., Yoshida T., Noguchi Y., Misawa N., Yasuda T., Saito Y., Kohn L.D., and Tatsuno I. Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. Biochem. Biophys. Res. Commun. 315 (2004) 1147-1153
24. Vicent D., Maratos-Flier E., and Kahn C.R. The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Mol. Cell Biol. 20 (2000) 2158-2166
25. Misawa N., Satomi Y., Kondo K., Yokoyama A., Kajiwara S., Saito T., Ohtani T., and Miki W. Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J. Bacteriol. 177 (1995) 6575-6584
26. Ohnuma S., Suzuki M., and Nishino T. Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase. J. Biol. Chem. 269 (1994) 14792-14797
27. Suzuki A., Ghayor C., Guicheux J., Magne D., Quillard S., Kakita A., Ono Y., Miura Y., Oiso Y., Itoh M., and Caverzasio J. Enhanced expression of the inorganic phosphate transporter Pit-1 is involved in BMP-2-induced matrix mineralization in osteoblast-like cells. J. Bone Miner. Res. 21 (2006) 674-683
28. Crick D.C., Andres D.A., and Waechter C.J. Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. Biochem. Biophys. Res. Commun. 237 (1997) 483-487
29. Sudo H., Kodama H.A., Amagai Y., Yamamoto S., and Kasai S. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell Biol. 96 (1983) 191-198
30. Quarles L.D., Yohay D.A., Lever L.W., Caton R., and Wenstrup R.J. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J. Bone Miner. Res. 7 (1992) 683-692
31. Choi J.Y., Lee B.H., Song K.B., Park R.W., Kim I.S., Sohn K.Y., Jo J.S., and Ryoo H.M. Expression patterns of bone-related proteins during osteoblastic differentiation in MC3T3-E1 cells. J. Cell Biochem. 61 (1996) 609-618
32. Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T., Rosen V., Wozney J.M., Fujisawa-Sehara A., and Suda T. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127 (1994) 1755-1766
33. Teboul L., Gaillard D., Staccini L., Inadera H., Amri E.Z., and Grimaldi P.A. Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. J. Biol. Chem. 270 (1995) 28183-28187