Interstitial Cells of Cajal in Dysmotility in Intestinal Ischemia and Reperfusion Injury in Rats

Journal of Surgical Research

Volumn 135, Issue 2, 2006, Pages 255-261

  Shimojima, Naoki ^a   Nakaki, Toshio ^b   Morikawa, Yasuhide ^a   Hoshino, Ken ^a   Ozaki, Hiroshi ^c   Hori, Masatoshi ^c   Kitajima, Masaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

c Kit; contraction; enteric nervous system; gastrointestinal motility; intestine; pacemaker; small bowel transplantation

Indexed keywords

PGP9.5 POLYCLONAL ANTIBODY; POLYCLONAL ANTIBODY; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GASTROINTESTINAL MOTILITY; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; INTESTINE CONTRACTION; INTESTINE GRAFT; INTESTINE INNERVATION; INTESTINE ISCHEMIA; INTESTINE MUSCLE; MALE; MESENTERIC ARTERY OCCLUSION; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SMALL INTESTINE RESECTION;

ANIMALS; GASTROINTESTINAL TRANSIT; IMMUNOHISTOCHEMISTRY; INTESTINES; MALE; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RATS, WISTAR; REPERFUSION INJURY; UBIQUITIN THIOLESTERASE;

EID: 33748771203     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.04.022     Document Type: Article

References (35)

1. Hierholzer C., Kalff J.C., Audolfsson G., et al. Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Transplantation 68 (1999) 1244
2. Alican I., Yegen C., Olcay A., et al. Ischemia-reperfusion-induced delay in intestinal transit. Role of endothelins. Digestion 59 (1998) 343
3. Udassin R., Eimerl D., Schiffman J., et al. Postischemic intestinal motility in rat is inversely correlated to length of ischemia. An in vivo animal model. Dig Dis Sci 40 (1995) 1035
4. Hassoun H.T., Weisbrodt N.W., Mercer D.W., et al. Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults. J Surg Res 97 (2001) 150
5. Hebra A., Hong J., McGowan K.L., et al. Bacterial translocation in mesenteric ischemia-reperfusion injury: is dysfunctional motility the link?. J Pediatr Surg 29 (1994) 280
6. Ballabeni V., Barocelli E., Bertoni S., et al. Alterations of intestinal motor responsiveness in a model of mild mesenteric ischemia/reperfusion in rats. Life Sci 71 (2002) 2025
7. Takahashi A., Tomomasa T., Kaneko H., et al. Intestinal motility in an in vivo rat model of intestinal ischemia-reperfusion with special reference to the effects of nitric oxide on the motility changes. J Pediatr Gastroenterol Nutr 33 (2001) 283
8. Cajal R.Y. Nuevas aplicaciones del metodo de coloracion de Golgi. Gac Med Catalana 12 (1889) 613
9. Sanders K.M. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 111 (1996) 492
10. Sanders K.M., Ordog T., Koh S.D., et al. Development and plasticity of interstitial cells of Cajal. Neurogastroenterol Motil 11 (1999) 311
11. Takayama I., Horiguchi K., Daigo Y., et al. The interstitial cells of Cajal and a gastroenteric pacemaker system. Arch Histol Cytol 65 (2002) 1
12. Sanders K.M., Ordog T., and Ward S.M. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 282 (2002) G747
13. Hirst G.D., and Ward S.M. Interstitial cells: involvement in rhythmicity and neural control of gut smooth muscle. J Physiol 550 (2003) 337
14. Ward S.M., Burns A.J., Torihashi S., et al. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 480 (1994) 91
15. Huizinga J.D., Thuneberg L., Kluppel M., et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373 (1995) 347
16. Maeda H., Yamagata A., Nishikawa S., et al. Requirement of c-kit for development of intestinal pacemaker system. Development 116 (1992) 369
17. Torihashi S., Ward S.M., Nishikawa S., et al. c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 280 (1995) 97
18. Ward S.M., Harney S.C., Bayguinov J.R., et al. Development of electrical rhythmicity in the murine gastrointestinal tract is specifically encoded in the tunica muscularis. J Physiol 505 (1997) 241
19. Ward S.M., Brennan M.F., Jackson V.M., et al. Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle. J Physiol 516 (1999) 835
20. Torihashi S., Nishi K., Tokutomi Y., et al. Blockade of kit signaling induces transdifferentiation of interstitial cells of cajal to a smooth muscle phenotype. Gastroenterology 117 (1999) 140
21. Shimojima N., Nakaki T., Morikawa Y., et al. Imatinib blocks spontaneous mechanical activities in the adult mouse small intestine: possible inhibition of c-Kit signaling. Pharmacology 74 (2005) 95
22. Chang I.Y., Glasgow N.J., Takayama I., et al. Loss of interstitial cells of Cajal and development of electrical dysfunction in murine small bowel obstruction. J Physiol 536 (2001) 555
23. Nakaki T., Otsuka Y., Nakayama M., et al. Endothelium-accelerated hyporesponsiveness of norepinephrine-elicited contraction of rat aorta in the presence of bacterial lipopolysaccharide. Eur J Pharmacol 219 (1992) 311
24. Bielefeldt K., and Conklin J.L. Intestinal motility during hypoxia and reoxygenation in vitro. Dig Dis Sci 42 (1997) 878
25. Pluja L., Alberti E., Fernandez E., et al. Evidence supporting presence of two pacemakers in rat colon. Am J Physiol Gastrointest Liver Physiol 281 (2001) G255
26. Alberti E., Mikkelsen H.B., Larsen J.O., et al. Motility patterns and distribution of interstitial cells of Cajal and nitrergic neurons in the proximal, mid- and distal-colon of the rat. Neurogastroenterol Motil 17 (2005) 133
27. Yanagida H., Yanase H., Sanders K.M., et al. Intestinal surgical resection disrupts electrical rhythmicity, neural responses, and interstitial cell networks. Gastroenterology 127 (2004) 1748
28. Der T., Bercik P., Donnelly G., et al. Interstitial cells of cajal and inflammation-induced motor dysfunction in the mouse small intestine. Gastroenterology 119 (2000) 1590
29. Lu G., Qian X., Berezin I., et al. Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal. Am J Physiol 273 (1997) G1233
30. Suzuki T., Won K.J., Horiguchi K., et al. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Am J Physiol Gastrointest Liver Physiol 287 (2004) G638
31. Rumessen J.J. Ultrastructure of interstitial cells of Cajal at the colonic submuscular border in patients with ulcerative colitis. Gastroenterology 111 (1996) 1447
32. Porcher C., Baldo M., Henry M., et al. Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease. Am J Gastroenterol 97 (2002) 118
33. Granger D.N. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255 (1988) H1269
34. Cicalese L., Lee K., Schraut W., et al. Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am J Surg 171 (1996) 97
35. Cuzzocrea S., Mazzon E., Dugo L., et al. Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. Br J Pharmacol 132 (2001) 19