Medium and long term outcome of growth hormone theraphy in growth hormone deficient adults

Medicina

Volumn 66, Issue 4, 2006, Pages 296-302

  Fideleff, Hugo L ^a   Boquete, Hugo ^a   Giaccio, Ana ^a   Sobrado, Patricia ^a   Bruera, Darío ^b   Chervin, Alberto ^c   Hermberg, Haraldo Claus ^d   Levalle, Oscar ^e   Miras, Mirta ^f   Sinay, Isaac ^g   Stalldecker, Graciela ^h  

^a Hospital General De Agudos Teodoro Alvarez   (Argentina)

^b Hospital Clínicas de Córdoba   (Argentina)

^c Hosp S Lucia   (Argentina)

^d HOSPITAL ALEMÁN   (Argentina)

^e HOSPITAL DURAND   (Argentina)

^f Hospital de Ninos de la Santisima Trinidad   (Argentina)

^g Hosp de Niños ^*  (Argentina)

^h Hospital Pirovano   (Argentina)

Author keywords

Adult growth hormone deficiency; Growth hormone; Growth hormone treatment; Metabolic alterations

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; CHOLESTEROL; GLYCOSYLATED HEMOGLOBIN; GROWTH HORMONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABDOMINAL PAIN; ACUTE HEART INFARCTION; ADULT; AGED; ANEMIA; ARTHRALGIA; ARTICLE; ASTHENIA; ATHEROMATOSIS; BODY MASS; BONE MINERAL; BREAST ADENOMA; BRONCHITIS; CLINICAL PROTOCOL; CONTROLLED STUDY; DEPRESSION; DIABETES MELLITUS; DISEASE PREDISPOSITION; DRUG DOSE REGIMEN; DRUG FEVER; EDEMA; EPIGASTRIC DISCOMFORT; FACIAL NERVE PARALYSIS; FATIGUE; FEMALE; FRACTURE; GASTROENTERITIS; GENDER; GROWTH HORMONE DEFICIENCY; GYNECOMASTIA; HEADACHE; HEART INDEX; HEPATITIS; HUMAN; HYPERCALCIURIA; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOPHYSIS TUMOR; HYPOTENSION; INTERMITTENT CLAUDICATION; LIVER DYSFUNCTION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METRORRHAGIA; MYALGIA; ONSET AGE; OSTEOLYSIS; SJOEGREN SYNDROME; SLEEP APNEA SYNDROME; STROKE; TOOTH PAIN; TREATMENT OUTCOME; URINARY TRACT INFECTION; WEAKNESS;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; BIOLOGICAL MARKERS; BODY COMPOSITION; BODY MASS INDEX; CHOLESTEROL, HDL; EPIDEMIOLOGIC METHODS; FEMALE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; SEX FACTORS; TIME FACTORS; TREATMENT OUTCOME; WAIST-HIP RATIO;

EID: 33748752790     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Cuneo RC, Salomon F, McGauley GA, Sönksen PH. The growth hormone deficiency syndrome in adults. Clin Endocrinol (Oxf) 1992; 37: 387-97.
2. Carroll PV, Christ ER, Bengtsson B-Å, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab 1998; 83: 382-95.
3. Fideleff HL, Chervin A, Giaccio A, Sobrado P, Barmat R, Boquete H. Adult Growth Hormone Deficiency: Metabolic Alterations and Evaluation of Different Risk Groups. Medicina (Buenos Aires) 2004; 64: 13-9.
4. Salomon F, Cuneo RC, Hesp H, Sönksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989; 321: 1797-803.
5. Jorgensen JOL, Pedersen SA, Thuesen L, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989; 1221-5.
6. Bengtsson B-Å, Edén S, Lünn I, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993; 76: 309-17.
7. Drake WM, Coyte D, Camacho-Hubner C, et al. Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults. J Clin Endocrinol Metab 1998; 83: 3813-9.
8. Murray RD, Skillicorn CJ, Howell SJ, Lissett CA, Rahim A, Shalet SM. Dose titration and patient selection increases the efficacy of GH replacement in severely GH deficient adults. Clin Endocrinol (Oxf) 1999; 50: 749-57.
9. Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998; 83: 379-81.
10. Fideleff HL, Frigeri AE, Sobrado PG, Llano MN, Ruibal GF, Boquete HR. Reproducibility and variability of the arginine test in normal adults: Comparison between sexes. Medicina (Buenos Aires) 1999; 59: 249-53.
11. Siegel S. Non parametric statistics for the behavioral sciences, 5th ed. New York: Mc Graw, 1990.
12. Robert C Elston & William D Johnson. Principios de Bioestadística. Editorial: El Manual Moderno, S.A. de C.V. México, D.F.,1990, p 213-4.
13. Rosen T, Bengtsson B-Å. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285-8.
14. Bates AS, Van't Hoff W, Jones PJ, Clayton RN. The effect of hypoituitarism on life expectancy. J Clin Endocrinol Metab 1996; 81: 1169-72.
15. Binnerts A, Swart GR, Wilson JHP, et al. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeos-tasis, as well as body composition. Clin Endocrinol (Oxf) 1992; 37: 79-87.
16. Russell-Jones DL, Watts GF, Weissberger A, et al. The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult growth hormone deficient patients. Clin Endocrinol (Oxf) 1994; 41: 356-63.
17. Beshyah SA, Henderson A, Niththyananthan R, et al. The effects of short and long-term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. J Clin Endocrinol Metab 1995; 80: 356-63.
18. Beshyah SA, Freemantle C, Shahi M. Replacement therapy with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults. Clin Endocrinol (Oxf) 1995; 42: 73-81.
19. Burman P, Broman JE, Hetta J, et al. Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. J Clin Endocrinol Metab 1995; 80: 3585-90.
20. Underwood LE, Attie KM, Baptista J. Growth hormone (GH) dose-response in young adults with childhood-onset GH deficiency: A two-year, multicenter, multiple-dose, placebo-controlled study. J Clin Endocrinol Metab 2003; 88: 5273-80.
21. Boquete H, Sobrado P, Fideleff HL, et al. Evaluation of diagnostic accuracy of insulin-like growth factor (IGF)-I and IGF-binding protein-3 in growth hormone-deficient children and adults using Roc Plot analysis. J Clin Endocrinol Metab 2003, 88: 4702-8.
22. Vance ML, Mauras N. Growth hormone therapy in adults and children. N Engl J Med 1999; 341:1206-16.
23. Gibney J, Johannsson G. Long-term monitoring of insulin-like growth factor I in adult growth hormone deficiency: a critical appraisal. Horm Res 2004; 62 Suppl 1: 66-72.
24. Twickler T, Cramer M, Dallinga-Thie G, et al. Adult-onset growth hormone deficiency: Relation of postprandial dyslipidemia to premature atherosclerosis. J Clin Endocrinol Metab 2003; 88: 2479-88.
25. Gola M, Bonadonna S, Doga M, Giustina A. Growth hormone and cardiovascular risk factors. J Clin Endocrinol Metab 2005; 90: 1864-70.
26. Cooper GR, Jay Smith S, Myers GL, Sampson EJ, Magid E. Estimating and minimizing effects of biologic sources of variation by relative range when measuring the mean of serum lipids and lipoproteins. Clin Chem 1994; 40: 227-32.
27. Fideleff HL, Boquete HR. Growth hormone (GH) deficiency and GH replacement therapy: effects on cardiovascular function. In: Abs R and Feldt Rasmussen U (eds). 10 Years of KIMS. London: Oxford PharmaGenesis: 2004, p 149-59.
28. Fazio S, Palmieri EA, Biondi B, Cittadini A, Sacca L. The role of the GH-IGF-I axis in the regulation of myocardial growth: from experimental models to human evidence. Eur J Endocrinol 2000; 142: 211-6.
29. Hermberg H, Fideleff H, Chervin A, et al. Effects of GH on the mineral, lean and fat masses in pan-hypopituitary men and women. J Bone Min Res 2001; 16 (Suppl 1): S 408,
30. Attanasio AF, Lamberts SWJ, Matranga AMC, et al. Adult growth hormone (GH) - deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. J Clin Endocrinol Metab 1997; 82: 82-8.
31. Shalet S. Growth hormone (GH) replacement is not justified for all adults with GH deficiency. J Clin Endocrinol Metab 2000; 85: 933-9.
32. Giaccio A, Boquete H, Sobrado P, Fideleff HL. Deficiencia de GH y calidad de vida: diferente respuesta al tratamiento sustitutivo prolongado según el momento de inicio del déficit y el sexo. Rev Arg Endocrinol Metab 2004; 41: 56 (resumen).