Identification of critical residues for regulation of integrin activation in the β6-α7 loop of the integrin β3 I-like domain [5]

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 10, 2006, Pages 2278-2280

  Hato, Takaaki ^a   Yamanouchi, J ^a   Yakushijin, Y ^a   Sakai, I ^a   Yasukawa, M ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA7 INTEGRIN; BETA3 INTEGRIN; BETA6 INTEGRIN; COMPLEMENTARY DNA; FIBRINOGEN; LIGAND;

CHO CELL; CONFORMATIONAL TRANSITION; GENE MUTATION; LETTER; LIGAND BINDING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; THROMBUS; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD; BINDING SITES; BLOOD PLATELETS; CHO CELLS; CRICETINAE; HUMANS; INTEGRIN ALPHA CHAINS; INTEGRIN BETA CHAINS; INTEGRIN BETA3; INTEGRINS; LIGANDS; MODELS, MOLECULAR; MUTATION; PLATELET ADHESIVENESS; PROTEIN STRUCTURE, TERTIARY;

EID: 33748749178     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.02137.x     Document Type: Letter

References (9)

1. Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 2004; 432: 59-67.
2. Luo BH, Takagi J, Springer TA. Locking the β3 integrin I-like domain into high and low affinity conformations with disulfides. J Biol Chem 2004; 279: 10215-21.
3. Yamanouchi J, Hato T, Tamura T, Fujita S. Identification of critical residues for ligand binding in the integrin β3 I-domain by site-directed mutagenesis. Thromb Haemost 2002; 87: 756-62.
4. 3 subunit. J Biol Chem 1996; 271: 21978-84.
5. 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 1990; 249: 915-8.
6. 3 (GPIIb-IIIa) receptor function. J Biol Chem 1994; 269: 20913-9.
7. Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 2003; 112: 99-111.
8. Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin αVβ3. Science 2001; 294: 339-45.
9. 3. J Biol Chem 2000; 275: 7795-802.