Effect of repeated apotransferrin administrations on serum iron parameters in patients undergoing myeloablative conditioning and allogeneic stem cell transplantation

British Journal of Haematology

Volumn 135, Issue 2, 2006, Pages 228-234

  Parkkinen, Jaakko ^a,b,c   Sahlstedt, Leila ^d   Von Bonsdorff, Leni ^b   Salo, Hanna ^b   Ebeling, Freja ^b,d   Ruutu, Tapani ^d  

^a Finnish Red Cross Blood Transfusion Service ^*  (Finland)

^b FINNISH RED CROSS BLOOD SERVICE   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Erythropoiesis; Iron; Myeloablation; Stem cell transplantation; Transferrin

Indexed keywords

APOTRANSFERRIN; CYCLOPHOSPHAMIDE; IRON;

ADOLESCENT; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CELL CYCLE ARREST; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG MEGADOSE; ERYTHROID CELL; ERYTHROPOIESIS; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON TRANSPORT; MALE; MYELOABLATIVE CONDITIONING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; APOPROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ERYTHROPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IRON; MIDDLE AGED; PROSPECTIVE STUDIES; TRANSFERRIN; TRANSPLANTATION CONDITIONING;

EID: 33748745637     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06273.x     Document Type: Article

References (30)

1. Anderson, G.J. (1999) Non-transferrin-bound iron and cellular toxicity. Journal of Gastroenterology and Hepatology, 14, 105-108.
2. Azar, N., Valla, D., bdel-Samad, I., Hoang, C., Fretz, C., Sutton, L., Fournel, J.J., Le, C.Y., Binet, J.L., & Leblond, V. (1996) Liver dysfunction in allogeneic bone marrow transplantation recipients. Transplantation, 62, 56-61.
3. von Bonsdorff, L., Tolo, H., Lindeberg, E., Nyman, T., Harju, A. & Parkkinen, J. (2001) Development of a pharmaceutical apo-transferrin product for iron binding therapy. Biologicals, 29, 27-37.
4. von Bonsdorff, L., Lindeberg, E., Sahlstedt, L., Lehto, J. & Parkkinen, J. (2002) Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies. Clinical Chemistry, 48, 307-314.
5. von Bonsdorff, L., Sahlstedt, L., Ebeling, F., Ruutu, T. & Parkkinen, J. (2004) Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron. FEMS Immunology and Medical Microbiology, 40, 173-180.
6. Bradley, S.J., Gosriwitana, I., Srichairatanakool, S., Hider, R.C. & Porter, J.B. (1997) Non-transferrin-bound iron induced by myeloablative chemotherapy. Britsh Journal of Haematology, 99, 337-343.
7. Brissot, P., Wright, T.L., Ma, W.L. & Weisiger, R.A. (1985) Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states. Journal of Clinical Investigation, 76, 1463-1470.
8. Brittenham, G.M. (1994) The red cell cycle. In: Iron Metabolism in Health and Disease (ed. by J.H. Brock), pp. 31-42. WB Saunders, London.
9. Brock, J.H., Esparza, I. & Logie, A.C. (1984) The nature of iron released by resident and stimulated mouse peritoneal macrophages. Biochimica et Biophysicha Acta, 797, 105-111.
10. Carmine, T.C., Evans, P., Bruchelt, G., Evans, R., Handgretinger, R., Niethammer, D. & Halliwell, B. (1995) Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management. Cancer Letters, 94, 219-226.
11. Durken, M., Nielsen, P., Knobel, S., Finckh, B., Herrnring, C., Dresow, B., Kohlschutter, B., Stockschlader, M., Kruger, W.H., Kohlschutter, A. & Zander, A.R. (1997) Nontransferrin-bound iron in serum of patients receiving bone marrow transplants. Free Radical Biology and Medicine, 22, 1159-1163.
12. Esparza, I. & Brock, J. (1981) Release of iron by resident and stimulated mouse peritoneal macrophages following ingestion and degradation of transferrin-antitransferrin immune complexes. British Journal of Haematology, 49, 603-614.
13. Evans, P.J. & Halliwell, B. (1994) Measurement of iron and copper in biological systems: bleomycin and copper-phenanthroline assays. Methods in Enzymology, 233, 82-92.
14. Evens, A.M., Mehta, J. & Gordon, L. (2004) Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. Bone Marrow Transplantation, 34, 561-571.
15. Fillet, G., Beguin, Y. & Baldelli, L. (1989) Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation. Blood, 74, 844-851.
16. Finch, C.A., Huebers, H., Eng, M. & Miller, L. (1982) Effect of transfused reticulocytes on iron exchange. Blood, 59, 364-369.
17. Harrison, P., Neilson, J.R., Marwah, S.S., Madden, L., Bareford, D. & Milligan, D.W. (1996) Role of non-transferrin bound iron in iron overload and liver dysfunction in long term survivors of acute leukaemia and bone marrow transplantation. Journal of Clinical Pathology, 49, 853-856.
18. Hider, R.C. (2002) Nature of nontransferrin-bound iron. European Journal of Clinical Investigation, 32 (Suppl. 1), 50-54.
19. Lemasters, J.J. (2004) Rusty notions of cell injury. Journal of Hepatology, 40, 696-698.
20. Lesnikov, V., Lesnikova, M. & Deeg, H.J. (2001) Pro-apoptotic and anti-apoptotic effects of transferrin and transferrin-derived glycans on hematopoietic cells and lymphocytes. Experimental Hematology, 29, 477-489.
21. Lesnikov, V.A., Lesnikova, M.P., Shulman, H.M., Wilson, H.M., Hockenbery, D.M., Kocher, M., Pierpaoli, W. & Deeg, H.J. (2004) Prevention of Fas-mediated hepatic failure by transferrin. Laboratory Investigation, 84, 342-352.
22. Lipschitz, D.A., Simon, M.O., Lynch, S.R., Dugard, J., Bothwell, T.H. & Charlton, R.W. (1971) Some factors affecting the release of iron from reticuloendothelial cells. British Journal of Haematology, 21, 289-303.
23. McKay, P.J., Murphy, J.A., Cameron, S., Burnett, A.K., Campbell, M., Tansey, P. & Franklin, I.M. (1996) Iron overload and liver dysfunction after allogeneic or autologous bone marrow transplantation. Bone Marrow Transplantation, 17, 63-66.
24. Rama, R., Sanchez, J. & Octave, J.N. (1988) Iron mobilization from cultured rat bone marrow macrophages. Biochimica and Biophysica Acta, 968, 51-58.
25. Sahlstedt, L., Ebeling, F., von Bonsdorff, L., Parkkinen, J. & Ruutu, T. (2001) Non-transferrin-bound iron during allogeneic stem cell transplantation. British Journal of Haematology, 113, 836-838.
26. Sahlstedt, L., von Bonsdorff, L., Ebeling, F., Ruutu, T. & Parkkinen, J. (2002) Effective binding of free iron by a single intravenous dose of human apotransferrin in haematological stem cell transplant patients. British Journal of Haematology, 119, 547-553.
27. Saito, K., Nishisato, T., Grasso, J.A. & Aisen, P. (1986) Interaction of transferrin with iron-loaded rat peritoneal macrophages. British Journal of Haematology, 62, 275-286.
28. Stefanelli, M., Bentley, D.P., Cavill, I. & Roeser, H.P. (1984) Quantitation of reticuloendothelial iron kinetics in humans. American Journal of Physiology, 247, R842-R849.
29. Strasser, S.I., Kowdley, K.V., Sale, G.E. & McDonald, G.B. (1998) Iron overload in bone marrow transplant recipients. Bone Marrow Transplantation, 22, 167-173.
30. Weinberg, E.D. (1974) Iron and susceptibility to infectious disease. Science, 184, 952-956.