Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular cells: A histological, immunofluorescent, and ultrastructural study

Ultrastructural Pathology

Volumn 30, Issue 4, 2006, Pages 315-319

  Cai, Guoping ^a   Sidhu, Gurdip S ^b   Wieczorek, Rosemary ^b   Gu, Xin ^c   Herrera, Guillermo A ^c   Cubukcu Dimopulo, Olcay ^d   Kahn, Thomas ^d  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c Louisiana State University School of Medicine Shreveport   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Crystal; Immunoelectron microscopy; Kappa light chain; Plasma cell dyscrasia; Proximal tubulopathy; Ultrastructure

Indexed keywords

EOSIN; HEMATOXYLIN; LITHIUM; MELPHALAN; NORTRIPTYLINE; OLANZAPINE; PREDNISONE; RISPERIDONE; TRAZODONE; VALPROATE SEMISODIUM;

ADULT; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CELL DAMAGE; CLINICAL FEATURE; CRYSTAL STRUCTURE; FLOW CYTOMETRY; HISTOLOGY; HUMAN; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE DISORDER; LABORATORY TEST; LIGHT CHAIN; LYSOSOME; MALE; PERIODIC ACID SCHIFF STAIN; PHYSICAL EXAMINATION; PLASMA CELL DYSCRASIA; PRIORITY JOURNAL;

CRYSTALLIZATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; KIDNEY TUBULES, PROXIMAL; MALE; MICROSCOPY, ELECTRON; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; PARAPROTEINEMIAS;

EID: 33748714716     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.1080/019131290945727     Document Type: Article

References (19)

1. Herrera GA. Renal manifestations of plasma cell dyscrasias: an appraisal from the patients' bedside to the research laboratory. Ann Diagn Pathol. 2000;4:174-200.
2. Kyle RA. Monoclonal proteins and renal disease. Annu Rev Med. 1994;45:71-77.
3. Herrera GA. The contributions of electron microscopy to the understanding and diagnosis of plasma cell dyscrasia-related renal lesions. Med Electron Microsc. 2001;34:1-18.
4. Sanders PW, Herrera GA, Kirk KA, et al. Spectrum of glomerular and tubulointerstitial renal lesions associated with monotypical immunoglobulin light chain deposition. Lab Invest. 1991;64:527-537.
5. Start DA, Silva FG, Davis LD, et al. Myeloma cast nephropathy: immunohistochemical and lectin studies. Mod Pathol. 1988;1:336-347.
6. Sanders PW, Herrera GA, Lott RL, et al. Morphological alterations of the proximal tubules in light chain-related renal disease. Kidney Intl. 1988;33:881-889.
7. Truong LD, Mawad J, Cagle P, et al. Cytoplasmic crystals in multiple myeloma-associated Fanconi's syndrome: a morphological study including immunoelectron microscopy. Arch Pathol Lab Med. 1989;113:781-785.
8. Herrera GA, Sanders PW, Reddy BV, et al. Ultrastructural immunolabeling: a unique diagnostic tool in monoclonal light chain-related renal diseases. Ultrastruct Pathol. 1994;18:401-416.
9. Lajoie G, Leung R, Bargman JM. Clinical, biochemical, and pathological features in a patient with plasma cell dyscrasia and Fanconi syndrome. Ultrastruct Pathol. 2000;24:221-226.
10. Gu X, Barrios R, Cartwright J, et al. Light chain crystal deposition as a manifestation of plasma cell dyscrasias: the role of immunoelectron microscopy. Hum Pathol. 2003;34:270-277.
11. Finkel PN, Kronenberg K, Pesce AJ, et al. Adult Fanconi syndrome, amyloidosis and marked kappa-light chain proteinuria. Nephron. 1973;10:1-24.
12. Orfila C, Lepert JC, Modesto A, et al. Fanconi's syndrome, kappa light chain myeloma, non-amyloid fibrils and cytoplasmic crystals in renal tubular epithelium. Am J Nephrol. 1991;11:345-349.
13. Aucouturier P, Bauwens M, Khamlichi AA, et al. Monoclonal Ig L chain and L chain V domain fragment crystallization in myeloma-associated Fanconi's syndrome. J Immunol. 1993;150:3561-3568.
14. Batuman V, Guan S, O'Donovan R et al. Effect of myeloma light chains on phosphate and glucose transport in renal proximal tubule cells. Ren Physiol Biochem. 1994;17:294-300.
15. Pote A, Zwizinski C, Simon EE, et al. Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells. Am J Kidney Dis. 2000;36:735-744.
16. Sengul S, Zwizinski C, Simon EE, et al. Endocytosis of light chains induces cytokines through activation of NF-kappa B in human proximal tubule cells. Kidney Intl. 2002;62:1977-1988.
17. Leboulleaux M, Lelongt B, Mougenot B, et al. Protease resistance and binding of Ig light chains in myeloma-associated tubulopathies. Kidney Intl. 1995;48:72-79.
18. Decourt C, Bridoux F, Touchard G, et al. A monoclonal V kappa light chain responsible for incomplete proximal tubulopathy. Am J Kidney Dis. 2003;41:497-504.
19. Perazella MA. Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity. Am J Med Sci. 2003;325:349-362.