Successful treatment of pyridoxine-unresponsive homocystinuria with betaine in pregnancy [1]

Journal of Inherited Metabolic Disease

Volumn 29, Issue 5, 2006, Pages 688-689

  Pierre, Germaine ^a   Gissen, Paul ^a   Chakrapani, Anupam ^a   McDonald, Anita ^a   Preece, MaryAnne ^a   Wright, Joy ^a  

^a BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; HOMOCYSTEINE; PYRIDOXINE;

ADULT; AMINO ACID BLOOD LEVEL; CASE REPORT; DIET THERAPY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; GESTATION PERIOD; HOMOCYSTINURIA; HUMAN; LETTER; PATIENT MONITORING; PREGNANCY; PROTEIN RESTRICTION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; BETAINE; FEMALE; GASTROINTESTINAL AGENTS; HOMOCYSTINURIA; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PYRIDOXINE;

EID: 33748711047     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/s10545-006-0352-6     Document Type: Letter

References (5)

1. Levy HL, Vargas JE, Waisbren SE, et al (2002) Reproductive fitness in maternal homocystinuria due to cystathione β-synthase deficiency. J Inherit Metab Dis 25: 299-314.
2. Mathews A, Johnson TN, Chakrapani A, et al (2002) An indirect response model of homocyteine suppression by betaine: Optimising the dosage regimen of betaine in homocystinuria. J Clin Pharmacol 54: 140-146.
3. Mudd SH, Levy HL, Kraus JD (2001) Disorders of transsulfuration. In: Scriver CR, Sly WS, Valle D, eds; Childs B, Kinzler KW, Vogelstein B, assoc. eds. The Metabolic and Molecular Bases of Inherited Disease, 8th edn. New York: McGraw-Hill, 2007-2056.
4. Vilaseca MA, Cuartero ML, Martinez de Salinas M, et al (2004) Two successful pregnancies in pyridoxine-nonresponsive homocystinuria. J Inherit Metab Dis 27: 775-777.
5. Yap S, Barry-Kinsella C, Naughten ER (2001) Maternal pyridoxine non-responsive homocystinuria: The role of dietary treatment and anticoagulation. Br J Obstet Gynaecol 108: 425-428.