An indirect response model of homocysteine suppression by betaine: Optimising the dosage regimen of betaine in homocystinuria

British Journal of Clinical Pharmacology

Volumn 54, Issue 2, 2002, Pages 140-146

  Matthews, Angela ^a   Johnson, Trevor N ^b   Rostami Hodjegan, Amin ^b   Chakrapani, Anupam ^c   Wraith, J Edward ^c   Moat, Stuart J ^d   Bonham, James R ^a   Tucker, Geoffrey T ^b  

^a SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Betaine; Dose optimization; Homocystinuria; Pharmacokinetic pharmacodynamic modelling

Indexed keywords

BETAINE; CYSTATHIONINE BETA SYNTHASE; HOMOCYSTEINE;

ADOLESCENT; AGE; AMINO ACID ANALYSIS; ARTICLE; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; DATA ANALYSIS; DOSE CALCULATION; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; ENZYME DEFICIENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOCYSTINURIA; HUMAN; PATIENT COMPLIANCE; PRIORITY JOURNAL; SIMULATION; TIME;

ADMINISTRATION, ORAL; ADOLESCENT; BETAINE; CHILD; CYSTATHIONINE BETA-SYNTHASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HOMOCYSTEINE; HOMOCYSTINURIA; HUMANS; MALE; PYRIDOXINE; TREATMENT FAILURE;

EID: 0036040526     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2002.01620.x     Document Type: Article

References (26)

1. Disorders of transsulphation
2. Inherited disorders of cobolamin transport and metabolism
3. Inherited disorders of folate transport and metabolism
4. The natural history homocystinuria due to cystathionine β-synthase deficiency
5. The natural history of vascular disease in homocystinuria and the effects of treatment
6. A closer look in the eye in homocystinuria: A screened population
7. Strategies for the treatment of cystathionine β-synthase deficiency: The experience of the Willink Biochemical Genetics Unit over the past 30 years
8. Dietary treatment of homocystinuria
9. Treatment of homocystinuria with a low-methionine diet, supplemental cysteine, and a methyl donor
10. The use of betaine for the treatment of homocystinuria
11. Homocystinuria - The effects of betaine in the treatment of patients not responsive to pyridixime
12. Betaine for the treatment of homocysteine caused by methylenetetrahydrofolate reductase deficiency
13. Betaine in the treatment of homocystinuria due to 5, 10-methylenetetrahydrofolate reductase deficiency
14. Therapeutic approaches to cobolamin-C methylmalonic acidaemia and homocystinuria
15. Betaine therapy in homocystinuria
16. Homocistinuria. Eficacia del tratamiento con piridoxina, acido folico y betaina
17. Effects of betaine on S-adenosylmethionine levels in the cerebrospinal fluid in a patient with methyltetrahydrofolate reductase deficiency and peripheral neuropathy
18. The effect of oral betaine on vertebral body bone density in pyridixine-non-responsive homocystinuria
19. Betaine dose and treatment intervals for homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency
20. Pharmacokinetics of oral betaine in healthy subjects
21. Simple method for the routine determination of betaine and DMG in blood and urine
22. Recommended approaches for the laboratory measurement of homocysteine in the diagnosis and monitoring of patients with hyperhomocysteinaemia
23. Indirect pharmacodynamic response models do not require any parametric pharmacokinetic model to be fitted to effect time data
24. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related errors of metabolism
25. Paediatric clinical pharmacology and therapeutics
26. Clinical trial simulation in drug development