Enantiomeric separation of omeprazole and its metabolite 5-hydroxyomeprazole using non-aqueous capillary electrophoresis

Journal of Chromatography A

Volumn 1129, Issue 2, 2006, Pages 291-295

  Olsson, Jeanette ^a   Stegander, Filip ^a   Marlin, Nicola ^a   Wan, Hong ^b   Blomberg, Lars G ^a  

^a KARLSTAD UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

5 hydroxy omeprazole; Capillary electrophoresis; Cyclodextrin; Enantiomeric separation; Non aqueous; Omeprazole

Indexed keywords

5-HYDROXY-OMEPRAZOLE; CAPILLARY ELECTROPHORESIS; CYCLODEXTRIN; ENANTIOMERIC SEPARATION; OMEPRAZOLE;

ALCOHOLS; AMMONIUM COMPOUNDS; CARBOXYLIC ACIDS; ELECTROPHORESIS; GLUCOSE; METABOLITES; PARAMETER ESTIMATION;

NITROGEN COMPOUNDS;

5 HYDROXYOMEPRAZOLE; AMMONIUM ACETATE; BETA CYCLODEXTRIN DERIVATIVE; BUFFER; ELECTROLYTE; FORMIC ACID; HEPTAKIS(2,3 O DIMETHYL 6 O SULFO) BETA CYCLODEXTRIN; METHANOL; OMEPRAZOLE; OMEPRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; COMPUTER PROGRAM; DRUG DETERMINATION; DRUG STRUCTURE; ELECTRIC POTENTIAL; ENANTIOMER; ENANTIOSELECTIVITY; EXPERIMENTAL DESIGN; LOW TEMPERATURE; NONAQUEOUS PHASE LIQUID; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TEMPERATURE; VALIDATION STUDY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; CYCLODEXTRINS; ELECTROPHORESIS, CAPILLARY; OMEPRAZOLE; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 33748706841     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.07.001     Document Type: Article

References (24)

1. Richter J.E., Kahrilas P.J., Johanson J., Maton P., Breiter J.R., Hwang C., Marino V., Hamelin B., and Levine J.G. Am. J. Gastroenterol. 780 (2002) 459
2. Kanazawa H., Okada A., Higaki M., Yokota H., Mashige F., and Nakahara K. J. Pharm. Biomed. Anal. 30 (2003) 1817
3. Lämmerhofer M. J. Chromatogr. A 1068 (2005) 3
4. Porras S.P., and Kenndler E. J. Chromatogr. A 1037 (2004) 455
5. Porras S.P., Riekkola M.-L., and Kenndler E. Electrophoresis 24 (2003) 1485
6. Beckers J.L., Ackermans M.T., and Bocek P. Electrophoresis 24 (2003) 1544
7. Chankvetadze B., and Blaschke G. Electrophoresis 21 (2000) 4159
8. Riekkola M.-L. Electrophoresis 23 (2002) 3865
9. Sahota R.S., and Khaledi M.G. Anal. Chem. 66 (1994) 1141
10. Huie C.W. Electrophoresis 24 (2003) 1508
11. Riekkola M.-L., Jussila M., Porras S.P., and Valkó I.E. J. Chromatogr. A 892 (2000) 155
12. Steiner F., and Hassel M. Electrophoresis 21 (2000) 3994
13. Fillet M., Servais A.-C., and Crommen J. Electrophoresis 24 (2003) 1499
14. S.P. Porras, Doctoral thesis, Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, Helsinki, 2002.
15. Cole R.B. Electrospray Ionization Mass Spectrometry (1997), Wiley, Chichester
16. Porras S.P., Jyske P., Riekkola M.-L., and Kenndler E. J. Microcolum. Sep. 13 (2001) 149
17. Siren H., Kuldvee R., Karla T., Ekström T., and Riekkola M.-L. J. Chromatogr. A 1068 (2005) 89
18. Porras S.P., Riekkola M.-L., and Kenndler E. J. Chromatogr. A 905 (2001) 259
19. Wang F., and Khaledi M.G. J. Chromatogr. A 875 (2000) 277
20. Yang R., Schulman S.G., and Zavala P.J. Anal. Chim. Acta 481 (2003) 155
21. Wan H., Holmén A.G., Wang Y., Lindberg W., Englund M., Någård M.B., and Thompson R.A. Rapid Commun. Mass Spectrom. 17 (2003) 2639
22. Advanced Chemistry Development Inc. literature, ACD/Labs, 90 Adelaide Street, West Toronto, Ontario M5H3V9, Canada.
23. Nevado J.J.B., Peñalvo G.C., and Dorado R.M.R. Anal. Chim. Acta 533 (2005) 127
24. Miller J.N., and Miller J.C. Statistics and Chemometrics for Analytical Chemistry. fourth ed. (2000), Pearson Education, Essex, England p. 120