Increase of the M phenotype among erythromycin-resistant Streptococcus pneumoniae isolates from Spain related to the serotype 14 variant of the Spain9V-3 clone

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 9, 2006, Pages 3162-3165

  Ardanuy, C ^a   Fenoll, A ^b   Berron S ^b   Calatayud, L ^a   Linares J ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; MACROLIDE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CLONE; GENOTYPE; MEF GENE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEROTYPE; SPAIN; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; HUMANS; MEMBRANE PROTEINS; PNEUMOCOCCAL INFECTIONS; SPAIN; STREPTOCOCCUS PNEUMONIAE;

EID: 33748694363     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00269-06     Document Type: Article

References (34)

1. Amezaga, M. R., P. E. Carter, P. Cash, and H. McKenzie. 2002. Molecular epidemiology of erythromycin resistance in Streptococcus pneumonias isolates from blood and noninvasive sites. J. Clin. Microbiol. 40:3313-3318.
2. Ardanuy, C., F. Tubau, J. Liñares, M. A. Domínguez, R. Pallarés, R. Martín, and The Spanish Pneumococcal Infection Study Network (G03/103). 2005. Distribution of subclasses mef(A) and mef(E) of the mef(A) gene among clinical isolates of macrolide-resistant (M-phenotype) Streptococcus pneumoniae, viridans group streptococci, and Streptococcus pyogenes. Antimicrob. Agents Chemother. 49:827-829.
3. Bryskier, A. 2002. Viridans group streptococci: a reservoir of resistant bacteria in oral cavities. Clin. Microbiol. Infect. 8:65-69.
4. Cochetti, I., M. Vecchi, M. Mingoia, E. Tili, M. R. Catania, A. Manzin, P. E. Valardo, and M. P. Montanari. 2005. Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I). Antimicrob. Agents Chemother. 49:4999-5006.
5. Coffey, T. J., M. Daniels, M. C. Enright, and B. G. Spratt. 1999. Serotype 14 variants of the Spanish penicillin resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region. Microbiology 145:2023-2031.
6. Del Grosso, M., F. Iannelli, C. Messina, M. Santagati, N. Petrosillo, S. Stefani, G. Pozzi, and A. Pantosi. 2002. Macrolide efflux genes mef(A) and me/(E) are carried by different genetics elements in Streptococcus pneumoniae. J. Clin. Microbiol. 40:774-778.
7. Del Grosso, M., A. Scotto d'Abusco, F. Iannelli, G. Pozzi, and A. Pantosi. 2004. Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumonias. Antimicrob. Agents Chemother. 48:2037-2042.
8. Dias, R., and M. Canica. 2004. Emergence of invasive erythromycin- resistant Streptococcus pneumoniae strains in Portugal: contribution and phylogenetic relatedness of serotype 14. J. Antimicrob. Chemother. 54:1035-1039.
9. Dobay, O., F. Rozgonyi, and S. G. Amyes. 2005. Molecular characterisation of Hungarian macrolide-resistant Streptococcus pneumoniae isolates, including three highly resistant strains with the mef gene. Int. J. Antimicrob. Agents 25:488-495.
10. Doern, G. V., K. P. Heilmann, H. K. Huynh, P. R. Rhomberg, S. L. Coffman, and A. B. Brueggemann. 2001. Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995. Antimicrob. Agents Chemother. 45:1721-1729.
11. Enright, M. C., A. Fenoll, D. Griffiths, and B. G. Spratt. 1999. The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain. J. Clin. Microbiol. 37:3210-3216.
12. Enright, M. C., and B. G. Spratt. 1998. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology 144:3049-3060.
13. Farrell, D. J., S. G. Jenkins, S. D. Brown, M. Patel, B. S. Lavin, and K. P. Klugman. 2005. Emergence and spread of Streptococcus pneumoniae with erm(B) and mef(A) resistance. Emerg. Infect. Dis. 11:851-858.
14. Fenoll, A., I. Jado, D. Vicioso, A. Pérez, and J. Casal. 1998. Evolution of Streptococcus pneumoniae serotypes and antibiotic resistance in Spain: update (1990 to 1996). J. Clin. Microbiol. 36:3447-3454.
15. Fotopoulou, N., P. T. Tassios, D. V. Beste, S. Ioannidou, A. Efstratiou, E. R. Lawrence, J. Papaparaskevas, R. C. George, and N. J. Legakis. 2003. A common clone of erythromycin-resistant Streptococcus pneumoniae in Greece and the UK. Clin. Microbiol. Infect. 9:924-929.
16. Jacobs, M. R., D. Felmingham, P. C. Appelbaum, R. N. Grüneberg, and the Alexander Project Group. 2003. The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother. 52:229-246.
17. Klaassen, C. H. W., and J. W. Mouton. 2005. Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E). Antimicrob. Agents Chemother. 49:1271-1278.
18. Klugman, K. P., and J. R. Lonks. 2005. Hidden epidemic of macrolide resistant pneumococci. Emerg. Infect. Dis. 11:802-807.
19. Liñares, J., R. Pallarés, T. Alonso, J. L. Pérez, J. Ayats, F. Gudiol, P. F. Viladrich, and R. Martín. 1992. Trends in antimicrobial resistance of clinical isolates of Streptococcus pneumoniae in Bellvitge Hospital, Barcelona, Spain (1979-1990). Clin. Infect. Dis. 15:99-105.
20. 14-5). Microb. Drug Resist. 9:133-137.
21. McEllistrem, M. C., J. M. Adams, K. Shutt, J. T. Sanza, P. R. Facklam, C. G. Whitey, J. H. Jorgensen, and L. H. Harrison. 2005. Erythromycin- nonsusceptible Streptococcus pneumoniae in children, 1999-2001. Emerg. Infect. Dis. 11:969-972.
22. McGee, L., L. McDougal, J. Zhou, B. G. Spratt, F. C. Tenover, R. George, R. Hakenbeck, W. Hryniewicz, J. C. Lefevre, A. Tomasz, and K. P. Klugman. 2001. Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J. Clin. Microbiol. 39:2565-2571.
23. Monaco, M., R. Camilli, F. D'Ambrosio, M. del Grosso, and A. Pantosi. 2005. Evolution of erythromycin resistance in Streptococcus pneumoniae in Italy. J. Antimicrob. Chemother. 55:256-259.
24. Montanari, M. P., M. Mingoia, I. Cochetti, and P. E. Varaldo. 2003. Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy. J. Clin. Microbiol. 41:428-431.
25. Montanari, M. P., I. Cochetti, M. Mingoia, and P. E. Varaldo. 2003. Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 47:2236-2241.
26. Pérez-Trallero, E., C. García-de-la-Fuente, C. García-Rey, F. Baquero, L. Aguilar, R. Dal-Ré, J. García-de-Lomas and The Spanish Surveillance Group for Respiratory Pathogens. 2005. Geographical and ecological analysis of resistance, coresistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spain. Antimicrob. Agents Chemother. 49:1965-1972.
27. Reinert, R. R., A. Ringelstein, M. van der Linden, M. Y. Cil, A. Al-Lahham, and F. J. Schmitz. 2005. Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe. J. Clin. Microbiol. 43:1294-1300.
28. Roberts, M. C., J. Sutcliffe, P. Courvalin, L. B. Jensen, J. Rood, and H. Seppala. 1999. Nomenclature for macrolide and macrolide-lincosamide- streptogramin B resistance determinants. Antimicrob. Agents Chemother. 43:2823-2830.
29. Schmitz, F. J., M. Perdikouli, A. Beeck, J. Verhoef, and A. C. Fluit. 2001. Molecular surveillance of macrolide, tetracycline and quinolone resistance mechanisms in 1191 clinical European Streptococcus pneumoniae isolates. Int. J. Antimicrob. Agents 18:433-436.
30. Serai, C., F. J. Castillo, M. C. Rubio-Calvo, A. Fenoll, C. García, and R. Gómez-Lus. 2001. Distribution of resistance genes tet(M), aph3′-II, catpC194 and the integrase gene of Tn1545 in clinical Streptococcus pneumoniae harboring erm(B) and mef(A) genes in Spain. J. Antimicrob. Chemother. 47:863-866.
31. Sutcliffe, J., A. Tait-Kamradt, and L. Wondrack. 1996. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by efflux system. Antimicrob. Agents Chemother. 40:1817-1824.
32. Sutcliffe, J., T. Grebe, A. Tait-Kamradt, and L. Wondrack. 1996. Detection of erythromycin-resistant determinants by PCR. Antimicrob. Agents Chemother. 40:2562-2566.
33. Tenover, F. C., R. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulse-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
34. Wierzbowski, A. K., D. Swedlo, D. Boyd, M. Mulvey, K. A. Nichol, D. J. Hoban, and G. G. Zhanel. 2005. Molecular epidemiology and prevalence of macrolide efflux genes me/(A) and mef(E) in Streptococcus pneumoniae obtained in Canada from 1997 to 2002. Antimicrob. Agents Chemother. 49:1257-1261.