Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure

Neuroscience Letters

Volumn 407, Issue 2, 2006, Pages 156-161

  Suzuki, Rie ^a   Porreca, Frank ^b   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Central sensitisation; Descending facilitation; Electrophysiology; Hyperalgesia; Opioids; Spinal cord

Indexed keywords

MORPHINE; SODIUM CHLORIDE;

AFFERENT NERVE GROUP 1; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MAPPING; CONTROLLED STUDY; DOSE RESPONSE; ELECTROPHYSIOLOGY; EVOKED RESPONSE; EXPOSURE; HYPERALGESIA; MECHANICAL STIMULATION; NERVE CELL EXCITABILITY; NERVE FIBER C; NOCICEPTION; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SPINAL CORD DORSAL HORN; THERMAL STIMULATION;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HEAT; HINDLIMB; MORPHINE; NEURAL PATHWAYS; NEURONAL PLASTICITY; PHYSICAL STIMULATION; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1;

EID: 33748690517     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.08.027     Document Type: Article

References (35)

1. Ali N. Hyperalgesic response in a patient receiving high concentrations of spinal morphine. Anesthesiology 65 (1986) 449
2. Arner S., Rawal N., and Gustafsson L.L. Clinical experience of long-term treatment with epidural and intrathecal opioids-a nationwide survey. Acta Anaesthesiol. Scand. 32 (1988) 253-259
3. Besse D., Lombard M.C., Zajac J.M., Roques B.P., and Besson J.M. Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Res. 521 (1990) 15-22
4. Burgess S., Gardell L., Ossipov M., Malan Jr. T., Vanderah T., Lai J., and Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J. Neurosci. 22 (2002) 5129-5136
5. Camilleri M., Northcutt A., Kong S., Dukes G., McSorley D., and Mangel A. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet 355 (2000) 1035-1040
6. Celerier E., Laulin J., Corcuff J.-B., Le Moal M., and Simonnet G. Progressive enhancement of delayed hyperalgesia induced by repeated herin administration: a sensitization process. J. Neurosci. 21 (2001) 4074-4080
7. Chu L., Clark D., and Angst M. Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study. J. Pain 7 (2006) 43-48
8. De Conno F., Caraceni A., Martini C., Spoldi E., Salvetti M., and Ventafridda V. Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine. Pain 47 (1991) 337-339
9. Devulder J. Hyperalgesia induced by high-dose intrathecal sufentanil in neuropathic pain. J. Neurosurg. Anesthesiol. 9 (1997) 146-148
10. Dickenson A. Where and how do opioids act?. In: Gebhart G., Hammond D., and Jensen T. (Eds). Proceedings of the 7th World Congress on Pain. Progress in pain research and management vol. 2 (1994), IASP Press, Seattle 525-552
11. Farber L., Stratz T., Bruckle W., Spath M., Pongratz D., Lautenschlager J., Kotter I., Zoller B., Peter H., Neeck G., Alten R., and Muller W. Efficacy and tolerability of tropisetron in primary fibromyalgia-a highly selective and competitive 5-HT3 receptor antagonist. Scand. J. Rheumatol. 113 Supplement (2000) 49-54
12. Gardell L., King T., Ossipov M., Rice K., Lai J., Vanderah T., and Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neurosci. Lett. (2005)
13. Gardell L.R., Wang R., Burgess S.E., Ossipov M.H., Vanderah T.W., Malan Jr. T.P., Lai J., and Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J. Neurosci. 22 (2002) 6747-6755
14. King T., Gardell L., Wang R., Vardanyan A., Ossipov M., Malan Jr. T.P., Vanderah T., Hunt S., Hruby V., Lai J., and Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain 116 (2005) 276-288
15. King T., Ossipov M., Vanderah T., Porreca F., and Lai J. Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?. Neurosignals 14 (2005) 194-205
16. Lembo A., Weber H., and Farraye F. Alosetron in irritable bowel syndrome: strategies for its use in a common gastrointestinal disorder. Drugs 63 (2003) 1895-1905
17. Mao J., Price D.D., and Mayer D.J. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62 (1995) 259-274
18. Ossipov M., Lai J., King T., Vanderah T., and Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers 80 (2005) 319-324
19. Ossipov M.H., Lai J., Vanderah T.W., and Porreca F. Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sci. 73 (2003) 783-800
20. Papadopoulos I., Georgiou P., Katsimbri P., and Drosos A. Treatment of fibromyalgia with tropisetron, a 5HT3 serotonin antagonist, a pilot study. Clin. Rheumatol. 19 (2000) 6-8
21. Porreca F., Ossipov M., and Gebhart G. Chronic pain and medullary descending facilitation. Trends Neurosci. 25 (2002) 319-325
22. Ren K., and Dubner R. Descending modulation in persistent pain: an update. Pain 100 (2002) 1-6
23. Stillmanl M., Moulin D., and Foley K. Paradoxical pain following high dose spinal morphine. Pain 30 (1987) S389
24. Suzuki R., Morcuende S., Webber M., Hunt S., and Dickenson A. Superficial NK1 expressing neurones control spinal excitability by activation of descending pathways. Nat. Neurosci. 5 (2002) 1319-1326
25. Suzuki R., Rahman W., Hunt S., and Dickenson A. Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury. Brain Res. 1019 (2004) 68-76
26. Suzuki R., Rahman W., Rygh L., Webber M., Hunt S., and Dickenson A. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain 117 (2005) 292-303
27. Suzuki R., Rygh L., and Dickenson A. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol. Sci. 25 (2004) 613-617
28. Urban M., and Gebhart G. Supraspinal contributions to hyperalgesia. Proc. Natl. Acad. Sci. USA 95 (1999) 2630-2635
29. Vanderah T.W., Gardell L.R., Burgess S.E., Ibrahim M., Dogrul A., Zhong C.M., Zhang E.T., Malan Jr. T.P., Ossipov M.H., Lai J., and Porreca F. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J. Neurosci. 20 (2000) 7074-7079
30. Vanderah T.W., Ossipov M.H., Lai J., Malan Jr. T.P., and Porreca F. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain 92 (2001) 5-9
31. Vanderah T.W., Suenaga N.M., Ossipov M.H., Malan Jr. T.P., Lai J., and Porreca F. Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. J. Neurosci. 21 (2001) 279-286
32. Vera-Portocarrero L., Zhang E., Ossipov M., Xie J., King T., Lai J., and Porreca F. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience 140 (2006) 1311-1320
33. Watanabe C., Sakurada T., Okuda K., Sakurada C., Ando R., and Sakurada S. The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats. Pain 106 (2003) 269-283
34. Yaksh T.L., and Harty G.J. Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine. J. Pharmacol. Exp. Therap. 244 (1988) 501-507
35. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110