Small mimotopes are big in identifying B-cell epitopes

Blood

Volumn 108, Issue 6, 2006, Pages 1794-1795

  Jensen Jarolim, Erika ^a   Riemer, Angelika B ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIBODY; EPITOPE; RITUXIMAB; VACCINE;

ANTIGEN ANTIBODY COMPLEX; B LYMPHOCYTE; BINDING AFFINITY; DRUG BINDING; HUMAN; NOTE; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE HOMOLOGY;

EID: 33748684382     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-07-034181     Document Type: Note

References (7)

1. Ghetie M-A, Bright H, Vitetta ES. Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood. 2001;97:1392-1398.
2. Ernst JA, Li H, Kim HS, Nakamura GR, Yansura DG, Vandlen RL. Isolation and characterization of the B-cell marker CD20. Biochemistry. 2005;44:15150-15158.
3. Polyak MJ, Deans JP. Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Blood. 2002;99:3256-3262.
4. Felici F, Luzzago A, Folgori A, Cortese R. Mimicking of discontinuous epitopes by phage-displayed peptides, II: selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries. Gene. 1993;128:21-27.
5. Riemer AB, Kraml G, Scheiner O, Zielinski CC, Jensen-Jarolim E. Matching of trastuzumab (Herceptin®) epitope mimics onto the surface of Her-2/neu: a new method of epitope definition. Mol Immunol. 2005;42:1121-1124.
6. Riemer AB, Klinger M, Wagner S, et al. Generation of peptide mimicsof the epitope recognized by trastuzumab on the oncogenic protein Her-2/neu. J Immunol. 2004;173:394-401.
7. Li S, Schmitz KR, Jeffrey PD, Wiltzius JJW, Kussie P, Ferguson KM. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell. 2005;7:301-311.