Long-acting muscarinic M3 receptor antagonists - Theravance

Expert Opinion on Therapeutic Patents

Volumn 16, Issue 9, 2006, Pages 1321-1326

  Norman, Peter ^a  

^a NORMAN CONSULTING   (United Kingdom)

Author keywords

Bronchodilator; COPD; M3; Muscarinic antagonist; Receptor; Urinary incontinence

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIPHENYL DERIVATIVE; BIPHENYLCARBAMOYL DERIVATIVE; DARIFENACIN; DIPHENYLEMTHYL DERIVATIVE; LONG ACTING DRUG; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; OXOTREMORINE; SALMETEROL; TD 5742; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG; YM 46303;

ARTICLE; BRONCHODILATATION; CHOLINERGIC RECEPTOR BLOCKING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; DRUG DESIGN; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEALTH CARE COST; HUMAN; NONHUMAN; OVERACTIVE BLADDER; PATENT; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; URINE INCONTINENCE;

EID: 33748682317     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.16.9.1321     Document Type: Article

References (9)

1. BARNES PJ: The role of anticholinergics in chronic obstructive pulmonary disease. Am. J. Med. (2004) 117(Suppl. 12A):24S-32S.
2. KOUMIS T, SAMUEL S: Tiotropium bromide: a new long-acting bronchodilator for the treatment of chronic obstructive pulmonary disease. Clin. Ther. (2005) 27(4):377-392.
3. COULSON FR, FRYER AD: Muscarinic acetylcholine receptors and airway diseases. Pharmacol. Ther. (2003) 98(1):59-69.
4. 3 receptor antagonists 1 GlaxoSmithKline. Expert Opin. Ther. Patents (2006) 16 preceding article.
5. HEGDE SS, MAMMEN M, JASPER JR: Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies. Curr. Opin. Investig. Drugs. (2004) 5(1):40-49.
6. 2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite. Mol. Pharmacol. (1996) 49(1):182-189.
7. EGLEN RM: Muscarinic receptor subtype pharmacology and physiology. Prog. Med. Chem. (2005) 43:105-136.
8. ZLOTOS DP, BENDER W, HOLZGRABE U: Muscarinic receptor agonists and antagonists. Expert Opin. Ther. Patents, (1999) 9(8):1029-1053
9. NAITO R, TAKEUCHI M, MORIHIRA K et al.: Selective muscarinic antagonists. II. 1) Synthesis and antimuscarinic properties of biphenylycarbamate derivatives. Chem. and Pharm. Bull (1998) 46(8):1286-1294.