An in vitro investigation on acid catalyzed reactions of proton pump inhibitors in the absence of an electrophile

International Journal of Pharmaceutics

Volumn 323, Issue 1-2, 2006, Pages 110-116

  Tutunji, Maha F ^a,b   Qaisi, Ali M ^a   El Eswed, Bassam ^c   Tutunji, L F ^a  

^a UNIVERSITY OF JORDAN   (Jordan)

^b ROYAL SCIENTIFIC SOCIETY   (Jordan)

^c AL BALQA APPLIED UNIVERSITY   (Jordan)

Author keywords

Degradation; Polarography; Proton pump inhibitor

Indexed keywords

ACID; BENZIMIDAZOLE DERIVATIVE; BUFFER; LANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; SULFENAMIDE DERIVATIVE;

ALKALINITY; ARTICLE; CATALYSIS; DECOMPOSITION; DEGRADATION; DIFFERENTIAL PULSE POLAROGRAPHY; DRUG ACCUMULATION; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG TRANSFORMATION; ELECTRODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PRIORITY JOURNAL; STOMACH PARIETAL CELL; ULTRAVIOLET SPECTROSCOPY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ACIDS; ANTI-ULCER AGENTS; CATALYSIS; DIMERIZATION; DRUG STABILITY; ELECTROCHEMISTRY; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; OMEPRAZOLE; POLAROGRAPHY; PROTON PUMPS;

EID: 33748680488     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.05.057     Document Type: Article

References (11)

1. Brändström A., Lindberg P., Bergman N.A., Alminger T., Anker K., Junggren U., Lamm B., Nordberg P., Erickson M., Grundevik I., Hagin I., Hoffmann K., Johnsson S., Larsson S., Löfberg I., Ohlson K., Persson B., Skänberg I., and Tekenbergs-Hjelte L. Chemical reactions of omeprazole and omeprazole analogues. I. A survey of the chemical transformations of omeprazole and its analogues. Acta Chem. Scand. 43 (1989) 536-548
2. Brändström A., Bergman N.A., Lindberg P., Grundevik I., Johnsson S., Tekenbergs-Hjelte L., and Ohelson K. Chemical reactions of omeprazole and omeprazole analogues. II. Kinetics of the reaction of omeprazole in the presence of 2-mercaptoethanol. Acta Chem. Scand. 43 (1989) 549-568
3. Brändström A., Bergman N.A., Grundevik I., Johnsson S., Tekenbergs-Hjelte L., and Ohlson K. Chemical reactions of omeprazole and omeprazole analogues. III. Protolytic behavior of compounds in the omeprazole system. Acta Chem. Scand. 43 (1989) 569-576
4. Brändström A., Lindberg P., Bergman N.A., Tekenbergs-Hjelte L., and Ohelson K. Chemical reactions of omeprazole and omeprazole analogues. IV. Reactions of compounds of the omeprazole system with 2-mercaptoethanol. Acta Chem. Scand. 43 (1989) 577-586
5. Brändström A., Lindberg P., Bergman N.A., Tekenbergs-Hjelte L., Ohelson K., Grundevik I., Nordberg P., and Alminger T. Chemical reactions of omeprazole and omeprazole analogues. V. The reaction of N-alkylated derivatives of omeprazole analogues with 2-mercaptoethanol. Acta Chem. Scand. 43 (1989) 587-594
6. Brändström A., Lindberg P., Bergman N.A., Grundevik I., Johnsson S., Tekenbergs-Hjelte L., and Ohelson K. Chemical reactions of omeprazole and omeprazole analogues. VI. The reactions of omeprazole in the absence of 2-mercaptoethanol. Acta Chem. Scand. 43 (1989) 595-611
7. Cary F.A., and Sundberg R.J. Advanced Organic Chemistry, Part A (1983), Plenum Press
8. Lindberg P., Nordberg P., Alminger T., Brändström A., and Wallmark B. The mechanism of action of gastric acid secretion inhibitor omeprazole. J. Med. Chem. 29 (1986) 1327-1329
9. Qaisi A.M., Tutunji M.F., and Tutunji L.F. Acid decomposition of omeprazole in the absence of thiol: a differential pulse polarographic study at the static mercury drop electrode (SMDE). J. Pharm. Sci. 95 (2006) 384-391
10. +)-ATPase by proton pump inhibitors. J. Am. Chem. Soc. 126 (2004) 7800-7811
11. +)-adenosin triphodphate by omeprazole. J. Pharm. Sci. 95