DNA fragmentation factor (DFF45): Expression and prognostic value in serous ovarian cancer

Pathology Research and Practice

Volumn 202, Issue 10, 2006, Pages 713-720

  Brustmann, Hermann ^a  

^a Department of Pathology Thermenklinikum ^*  (Austria)

Author keywords

Apoptosis; DFF45; DNA fragmentation factor; Outcome; Ovarian carcinoma

Indexed keywords

CYTOPLASM PROTEIN; DNA FRAGMENTATION FACTOR 45; FORMALDEHYDE; KI 67 ANTIGEN; PARAFFIN; PROTEIN DFF45; PROTEIN P53; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER STAGING; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTADENOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; OVARY CANCER; OVARY CARCINOMA; PROGNOSIS; PROTEIN EXPRESSION; SCORING SYSTEM; TUMOR CELL; UPREGULATION;

EID: 33748672513     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2006.06.003     Document Type: Article

References (27)

1. Abel F., Sjoberg R.M., Ejeskar K., Krona C., and Martinsson T. Analyses of apoptotic regulators CASP9 and DFFA at IP36.2, reveal rare allelic variants in human neuroblastoma tumours. Br. J. Cancer 86 (2002) 596-604
2. Boulares A.H., Zoltoski A.J., Yakovlev A., Xu M., and Smulson M.E. Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. J. Biol. Chem. 276 (2001) 38185-38192
3. Brustmann H. Apoptotic bodies as a morphological feature in serous ovarian carcinoma: correlation with nuclear grade, Ki-67 and mitotic indices. Pathol. Res. Pract. 198 (2002) 85-90
4. Brustmann H. Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma: a clinicopathologic and immunohistochemical study. Gynecol. Oncol. 92 (2004) 268-276
5. Charrier L., Jarry A., Toquet C., Bou-Hanna C., Chedorge M., Denis M., Vallette G., and Laboisse C.L. Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer dells. Cancer Res. 62 (2002) 2169-2174
6. Dartsch D.C., Schaefer A., Boldt S., Kolch W., and Marquart H. Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis. Apoptosis 7 (2002) 537-548
7. Hara S., Miyake H., Arakawa S., Kamidono S., and Hara I. Over-expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo. J. Urol. 16 (2001) 2491-2494
8. Holmes W.F., Soprano D.R., and Soprano K.J. Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines. J. Cell. Physiol. 199 (2004) 317-329
9. Iwasa M., Imamura Y., Noriki S., Nishi Y., Kato H., and Fukuda M. Immunohistochemical detection of early-stage carcinogenesis of oral leukoplakia by increased DNA-instability and various malignancy markers. Eur. J. Histochem. 45 (2001) 333-346
10. Kerr J.F.R., Winterford C.M., and Harmon B.V. Apoptosis. Its significance in cancer and cancer therapy. Cancer 73 (1994) 13-26
11. Khalifeh I., Munkarah A.R., Lonardo F., Malone J.M., Morris R., Lawrence W.D., and Ali-Fehmi R. Expression of Cox-2, CD34, Bcl-2, and p53 and survival in patients with primary peritoneal serous carcinoma and primary ovarian serous carcinoma. Int. J. Gynecol. Pathol. 23 (2004) 162-169
12. Konishi S., Ishiguro H., Shibata Y., Kudo J., Terashita Y., Sagiura H., Koyama H., Kimura M., Sato A., Shinoda N., Kuwabara Y., and Fuji Y. Decreased expression of DFF45/ICAD is correlated with a poor prognosis in patients with esophageal carcinoma. Cancer 95 (2002) 2473-2478
13. Kowabata Y., Hirokawa M., Kitabayashi A., Horiuchi T., Kuruki J., and Miura A.B. Defective apoptotic signal transduction pathway downstream of caspase-3 in human B-lymphoma cells: a novel mechanism of nuclear apoptosis resistance. Blood 94 (1999) 3523-3530
14. Lechardeur D., Drzymala L., Sharma M., Zylka D., Kinach R., Pacia J., Hicks C., Usmani N., Zylka D., Rommens L., and Lukacs C.L. Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD). J. Cell. Biol. 150 (2000) 321-334
15. Liu X., Zou H., Slaughter C., and Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89 (1997) 175-184
16. McMenamin M.E., ONeill A.J., and Gaffney E.F. Extent of apoptosis in ovarian serous carcinoma: relation to mitotic and proliferative indices, p53 expression, and survival. J. Clin. Pathol. Molec. Pathol. 50 (1997) 242-246
17. Prat J. Pathology of the Ovary (2004), Saunders, Philadelphia
18. Ramuz O., Isnardon D., Devilard E., Charafe-Jauffret E., Hassoun J., Birg F., and Xerri L. Constitutive nuclear localization and initial cytoplasmic apoptotic activity of endogenous caspase-3 evidenced by confocal microscopy. Int. J. Exp. Pathol. 84 (2003) 75-81
19. Sabol S.L., Li R., Lee T.Y., and Abdul-Khalek R. Inhibition of apoptosis-associated DNA fragmentation activity in nonapoptotic cells: the role of DNA fragmentation factor-45 (DFF45/ICAD). Biochem. Biophys. Res. Commun. 253 (1998) 151-158
20. Sakahira H., Enari M., and Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptotis. Nature 391 (1998) 96-99
21. Scully R.E., Young R.H., and Clement PB P.B. Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube and Broad Ligament. Atlas of Tumor Pathology (1996), Armed Forces Institute of Pathology, Washington, DC p. 37
22. Shimizu Y., Kamoi S., Amada S., Akiyama F., and Silverberg S.G. Toward the development of an universal grading system for ovarian epithelial carcinoma. Cancer 82 (1998) 893-901
23. Staunton M.J., and Gaffney E.F. Tumor type is a determinant of susceptibility to apoptosis. Am. J. Clin. Pathol. 103 (1995) 300-307
24. Sun A., Noriki S., Imamura Y., and Fukuda M. Detection of cancer clones in human gastric adenoma by increased DNA-instability and other biomarkers. Eur. J. Histochem. 47 (2003) 111-122
25. Widlak P., and Garrard W.T. Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G. J. Cell. Biochem. 94 (2005) 1078-1087
26. Xerri L., Palmerini F., Devilard E., Defrance T., Bouabdallah R., Hassoun J., and Birg F. Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas. J. Pathol. 192 (2000) 194-202
27. Zhang J., Wang X., Bove K.E., and Xu M. DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J. Biol. Chem. 274 (1999) 37450-37454