Generation of a mouse for conditional excision of progesterone receptor

Genesis (United States)

Volumn 44, Issue 8, 2006, Pages 391-395

  Hashimoto Partyka, Minako K ^a   Lydon, John P ^b   Iruela Arispe, M Luisa ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Gene targeting; Mammary gland; Ovary; Steroid receptors; Uterus

Indexed keywords

PROGESTERONE RECEPTOR;

ALLELE; ARTICLE; EXON; GENE INACTIVATION; GENE TARGETING; HOMOZYGOSITY; LOXP SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

MAMMALIA;

EID: 33748666407     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20227     Document Type: Article

References (18)

1. Allen W. 1930. Physiology of the corpus luteum, V: The preparation and some chemical properties of progestin, a hormone of the corpus luteum which produces progestational proliferation. Am J Physiol 92:174-188.
2. Apostolakis EM, Garai J, Fox C, Smith CL, Watson SJ, Clark JH, O'Malley BW. 1996. Dopaminergic regulation of progesterone receptors: Brain D5 dopamine receptors mediate induction of lordosis by D1-like agonists in rats. J Neurosci 16:4823-4834.
3. Conneely OM, Kettelberger DM, Tsai MJ, Schrader WT, O'Malley BW. 1989. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem 264:14062-14064.
4. Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP. 2000. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol 20:3102-3115.
5. Ismail PM, Li J, DeMayo FJ, O'Malley BW, Lydon JP. 2002. A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol 16:2475-2489.
6. Jenster G, Spencer TE, Burcin MM, Tsai SY, Tsai MJ, O'Malley BW. 1997. Steroid receptor induction of gene transcription: A two-step model. Proc Natl Acad Sci USA 94:7879-7884.
7. Kastner P, Krust A, Turcotte B. Stropp U, Tora L, Gronemeyer H, Chambon P. 1990. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614.
8. Kraus WL, Montano MM, Katzenellenbogen BS. 1994. Identification of multiple, widely spaced estrogen-responsive regions in the rat progesterone receptor gene. Mol Endocrinol 8:952-969.
9. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci USA 93:5860-5865.
10. Lee WS, Harder JA, Yoshizumi M, Lee ME, Haber E. 1997. Progesterone inhibits arterial smooth muscle cell proliferation. Nat Med 3:1005-1008.
11. Lewandoski M. 2001. Conditional control of gene expression in the mouse. Nat Rev Genet 2:743-755.
12. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA Jr, Shyamala G, Conneely OM, O'Malley BW. 1995. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 9:2266-2278.
13. Mulac-Jericevic B, Lydon JP, DeMayo FJ, Conneely OM. 2003. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci USA 100:9744-9749.
14. Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Lydon JP, Conneely OM. 2000. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 289:1751-1754.
15. Perrot-Applanat M, Groyer-Picard MT, Garcia E, Lorenzo F, Milgrom E. 1988. Immunocytochemical demonstration of estrogen and progesterone receptors in muscle cells of uterine arteries in rabbits and humans. Endocrinology 123:1511-1519.
16. Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS, Horwitz KB. 1994. A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Mol Endocrinol 8:1347-1360.
17. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
18. Vazquez F, Rodriguez-Manzaneque JC, Lydon JP, Edwards DP, O'Malley BW, Iruela-Arispe ML. 1999. Progesterone regulates proliferation of endothelial cells. J Biol Chem 274:2185-2192.