Mechanisms underlying autoimmunity in hematology

Drug Discovery Today: Disease Mechanisms

Volumn 3, Issue 2, 2006, Pages 231-235

  Semple, John W ^a,b   Freedman, John ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; CD4 ANTIGEN; COLD AGGLUTININ; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DICLOFENAC; ERYTHROCYTE ANTIBODY; GAMMUNEX; IMMUNOGLOBULIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LEVODOPA; MEFENAMIC ACID; METHYLDOPA; PREDNISONE; PROCAINAMIDE; RHESUS D ANTIBODY; RITUXIMAB; STEROID; VINCRISTINE; WHINRHOSDF;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ALLERGIC REACTION; ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; AUTOIMMUNE HEMOLYTIC ANEMIA; AUTOIMMUNE THROMBOCYTOPENIA; AUTOIMMUNITY; BODY WEIGHT DISORDER; BONE MARROW SUPPRESSION; CD4+ T LYMPHOCYTE; CELL DEATH; CHILL; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; GLUCOSE BLOOD LEVEL; HEADACHE; HEART PALPITATION; HELPER CELL; HEMATOLOGIC DISEASE; HERPES ZOSTER; HUMAN; HYPERTENSION; IMMUNE DEFICIENCY; INFECTION; INSOMNIA; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOOD DISORDER; MUSCLE ATROPHY; NONHUMAN; PATHOPHYSIOLOGY; RETICULOENDOTHELIAL SYSTEM; REVIEW; RIGOR; SPLENECTOMY; T LYMPHOCYTE ACTIVATION; WEIGHT GAIN;

EID: 33748654234     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2006.06.003     Document Type: Review

References (40)

1. Cines D.B., et al. Immune thrombocytopenic purpura. N. Engl. J. Med. 346 (2002) 995-1008
2. Wadenvik H., et al. Platelet proteins as autoantibody targets in idiopathic thrombocytopenic purpura. Acta. Paediatrica. 424 (1998) 26-36
3. Mehta Y.S., et al. Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP. Platelets 11 (2000) 94-98
4. McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin. Hematol. 37 (2002) 239-248
5. Coopamah M., et al. Cellular immune mechanisms in autoimmune thrombocytopenic purpura: an update. Transfus. Med. Rev. 17 (2005) 69-80
6. Blanchette V.S., et al. Intravenous immunoglobulin and Rh immunoglobulin as immunomodulators of autoimmunity to blood elements. In: Silberstein L.E. (Ed). Autoimmune Disorders of Blood (1996), American Association of Blood Banks Press 35-77
7. Wright J.F., et al. Characterization of platelet-reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura (ITP). Br. J. Haematol. 95 (1996) 145-152
8. Chia W.K., et al. Characterization of HIV-1-specific antibodies and HIV-1-crossreactive antibodies to platelets in HIV-1-infected haemophiliac patients. Br. J. Haematol. 103 (1998) 1014-1022
9. Semple J.W., et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura. Blood 87 (1996) 4225-4254
10. Semple J.W., et al. Enhanced anti-platelet lymphocyte reactivity in patients with autoimmune thrombocytopenia (AITP). Blood 78 (1991) 2619-2625
11. Ware R.R., et al. Phenotypic and clonal Analysis of T lymphocytes in childhood immune thrombocytopenic purpura. Blood 82 (1993) 2137-2142
12. Filion M.C., et al. Autoreactive T cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy. Eur. J. Immunol. 25 (1995) 3123-3127
13. Shimomura T., et al. Oligoclonal accumulation of T cells in peripheral blood from patients with idiopathic thrombocytopenic purpura. Br. J. Haematol. 95 (1996) 732-737
14. Kuwana M., et al. Autoreactive T cells to platelets GPIIbIIIa in immune thrombocytopenic purpura: a role in production of anti-platelet autoantibody. J. Clin. Invest. 102 (1998) 1393-1402
15. Kuwana M., et al. Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura. Blood 98 (2001) 130-139
16. Semple J.W., et al. Characterization and fine specificity of platelet-reactive T cell lines from children with chronic autoimmune thrombocytopenic purpura (AITP). Blood 98 (2001) 440a
17. Silberstein L.E., et al. Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone. Blood 67 (1986) 1705-1709
18. Potter K.N. Molecular characterization of cold agglutinins. Transfus. Sci. 22 (2000) 113-119
19. Semple J.W., et al. The etiology of autoimmune hemolytic anemia. Semin. Hematol. 42 (2005) 122-130
20. Coutelier J.J.P., et al. Involvement of CD4+ cells in lymphocytic choriomeningitis virus-induced autoimmune anemia. J. Autoimmun. 7 (1994) 589-599
21. Alenzi F.Q. Autoimmune haemolytic anaemia is associated with a defect in Fas-mediated apoptosis: a case report. Br. J. Biomed. Sci. 61 (2004) 96-98
22. Clauvel J.P., et al. HL-A antigens and idiopathic autoimmune hemolytic anemias. Transplant. Proc. 6 (1974) 447-448
23. Abdel-Khalik A., et al. Human leukocyte antigens A, B, C and DRW in idiopathic 'warm' autoimmune haemolytic anaemia. Br. Med. J. 280 (1980) 760-761
24. Shenoy S., et al. Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias. Clin. Immunol. 99 (2001) 266-275
25. Van De Loosdrecht A.A., et al. Excessive apoptosis of bone marrow erythroblasts in a patient with autoimmune haemolytic anaemia with reticulocytopenia. Br. J. Haematol. 108 (2000) 313-315
26. Aygun B., et al. Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions. Transfusion 42 (2002) 37-43
27. Arndt P.A., et al. The changing spectrum of drug-induced immune hemolytic anemia. Semin. Hematol. 42 (2005) 137-144
28. Castellino S.M., et al. Erythrocyte autoantibodies in paediatric patients with sickle cell disease receiving transfusion therapy: frequency, characteristics and significance. Br. J. Haematol. 104 (1999) 189-194
29. Cox K.O., et al. Impaired regulation of erythrocyte autoantibody production after splenectomy. Br. J. Exp. Pathol. 60 (1979) 466-470
30. Fagiolo E., et al. Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. Autoimmunity 36 (2003) 199-204
31. Elson C.J., et al. Immunologically ignorant autoreactive T cells: epitope spreading and repertoire limitation. Immunol. Today 16 (1995) 71-76
32. Barker R.N., et al. Multiple self epitopes on the rhesus polypeptide stimulate immunologically ignorant human T cells. Eur. J. Immunol. 24 (1994) 1578-1582
33. Barker R.N., et al. Identification of T cell epitopes on the rhesus polypeptides in autoimmune hemolytic anemia. Blood 90 (1996) 2701-2715
34. Ochiai K., et al. Genetic regulation of anti-erythrocyte autoantibodies and splenomegaly in autoimmune hemolytic anemia-prone New Zealand black mice. Int.s Immunol. 12 (2000) 1-8
35. Nisitani S., et al. Anti-red blood cell immunoglobulin transgenic mice. An experimental model of autoimmune hemolytic anemia. Ann. N. Y. Acad. Sci. 815 (1997) 246-252
36. Diiulio N., et al. The anti-erythrocyte autoimmune response of NZB mice. Identification of two distinct autoantibodies. Immunology 91 (1997) 246-251
37. Perry F., et al. Autoreactive T cell specificity in autoimmune hemolytic anemia of the NZB mouse. Eur. J. Immunol. 26 (1996) 136-141
38. Shen C., et al. T-helper 1 dominated responses to erythrocyte Band 3 in NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. Int. Immunol. 2 (1996) 1133-1142
39. Nisitani S., et al. Administration of IL5 or IL10 activates peritoneal B1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody transgenic mice. Eur. J. Immunol. 25 (1995) 3047-3052
40. Sakiyama T., et al. Requirement of IL5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice. Int. Immunol. 11 (1999) 995-1000