Trimetazidine increases [3H]glucose uptake in rat brain

Pharmacological Reports

Volumn 58, Issue 4, 2006, Pages 559-561

  Nowak, Przemysław ^a   Zagził, Tomasz ^a   Konecki, Janusz ^a   Szczerbak, Grazyna ^a   Szkilnik, Ryszard ^a   Niwiński, Janusz ^a   Gorzałek, Jarosław ^a   Kostrzewa, Richard M ^b   Brus, Ryszard ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b East Tennessee State University   (United States)

Author keywords

Brain; Rats; Trimetazidine; 3H glucose

Indexed keywords

GLUCOSE; HISTONE H3; METAZYDYNA; SODIUM CHLORIDE; TRIMETAZIDINE; TRITIUM; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DISSECTION; DRUG BRAIN LEVEL; DRUG EFFICACY; EXPERIMENTAL DESIGN; FRONTAL CORTEX; GLUCOSE TRANSPORT; HIPPOCAMPUS; HYPOTHALAMUS; LIQUID SCINTILLATION COUNTING; MALE; MEDULLA OBLONGATA; MULTIPLE DRUG DOSE; NEUROPROTECTION; NONHUMAN; PONS; RAT; RAT STRAIN; SINGLE DRUG DOSE; THALAMUS; ANIMAL; BRAIN; DOSE RESPONSE; DRUG EFFECT; METABOLISM; TIME; WISTAR RAT;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; MALE; RATS; RATS, WISTAR; TIME FACTORS; TRIMETAZIDINE; TRITIUM; VASODILATOR AGENTS;

EID: 33748641718     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Iqbal S, Baziany A, Hussain M, James S, Wright S, Hemmings S, Shnaib A, Rajput A: Trimetazidine as a potent neuroprotectant in transient global ischemia in gerbils: a behavioral and histological study. Brain Res, 2002, 928, 1-7.
2. Kantor PF, Lucień A, Kozak R, Lopaschuk GD: The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acids oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res, 2000, 86, 580-588.
3. Lopaschuk GD: Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated? Coron Artery Dis, 2001, 12, Suppl 1, S8-S11.
4. Lopaschuk GD, Barr R, Thomas PD, Dyck JR: Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of a long-chain 3-ketoacyl coenzyme A thiolase. Circ Res, 2003, 93, 33-37.
5. Oguzhanoglu A, Kurt T, Ortac R, Turman B: Somatosensory evoked potential and histopatological investigations in ischaemia-induced brain damage: effect of trimetazidine in rats. Int J Neurosci, 2003, 113, 447-454.
6. Smirnov AV, Krivoruchko BI, Zarubina IV, Miłonova OP: The antioxidant effects of amtizal and trimetazidine. Exp Clin Pharmacol, 1999, 62, 59-62.
7. Suzer T, Coskun E, Demir S, Tahta K: Lipid peroxidation and glutatione levels after cortical injection of ferric chloride in rats: effect of trimetazidine and deteroxamine. Res Exp Med, 2000, 199, 223-229.
8. 3H]glucose uptake in the brain and peripheral tissues of rats. Acta Biochim Pol, 2005, 52, Suppl 1, 116.
9. 3 receptor agonists. Pharmacol Rev Conimun, 1999, 10, 321-328.
10. Zini R, Simon N, Morin C, d'Athis P, Tillement JP: Inhibition of rat cerebral mitochondrial respiration by cyclosporins A, D and G and restoration with trimetazidine. C R Acad Sci III, 1996, 1087-1092.
11. Wiesinger H, Hamprecht B, Driugen R: Metabolic pathways for glucose in astrocytes. Glia, 1997, 21, 22-34.