Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: Effects of trimetazidine in rats

International Journal of Neuroscience

Volumn 113, Issue 4, 2003, Pages 447-454

  Oǧuzhanoǧlu, Atilla ^a   Kurt, Tülay ^a   Ortaç, Ragip ^b   Turman, Bülent ^c  

^a PAMUKKALE UNIVERSITY   (Turkey)

^b Behcet Uz Children's Hospital   (Turkey)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Brain damage; Evoked potential; Global ischaemia; Trimetazidine

Indexed keywords

S 5016; TRIMETAZIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DAMAGE; CONTROLLED STUDY; DRUG EFFECT; EVOKED SOMATOSENSORY RESPONSE; HIPPOCAMPUS; HISTOPATHOLOGY; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CHI-SQUARE DISTRIBUTION; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, SOMATOSENSORY; HIPPOCAMPUS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; STATISTICS, NONPARAMETRIC; TRIMETAZIDINE; VASODILATOR AGENTS;

EID: 0038067720     PISSN: 00207454     EISSN: None     Source Type: Journal    
DOI: 10.1080/00207450390162209     Document Type: Article

References (20)

1. Beckman, J. S. (1990). Ischaemic injury mediator. Nature, 345, 27-28.
2. Carceller, F., Roda, J. M., Gutiérrez-Molina, M., López-pajares, R., Albariño, A. R., & Diez-Tejedor, E. (1993). Can nimodipine prevent ischaemic reperfusion injury in the rat brain? Neurological Research, 15, 395-400.
3. Curti, D., Marzatico, F., Dagani, F., Villa, R., & Benzi, G. (1982). Effects of ischemia and pharmacological treatment on subcellular fractions from neonatal rat brain. Il Farmaco; edizione scientific, 37, 275-282.
4. Dalla-Volta, S., Maraglino, G., Della-Valentina, P., Viena, P., & Desideri, A. (1990). Comparison of Trimetazidine with Nifedipine in effort angina: A double-blind, crossover study. Cardiovascular Drugs and Therapy, 4, 853-860.
5. Harpey, C., Clauser, P., Labrid, C., Freyria, J. L., & Poirier, J. P. (1989). Trimetazidine, a cellular anti-ischemic agent. Cardiovascular Drug Reviews, 6, 292-312.
6. Hernandez, L. A., Grisham, M. B., Twohig, B., Arfors, K. E., Harlan, J. M., & Oranger, D. N. (1987). Role of neutrophils in ischemia-reperfusion-induced microvascular injury. American Journal of Physiology, 253, H699-H703.
7. Iqbal, S., Baziany, A, Hussain, M., James, S., Wright, S., Hemmings, S., Shuaib, A., & Rajput, A. (2002). Trimetazidine as a potential neuroprotection in transient global ischemia in gerbils: A behavioral and histological study. Brain Research, 928, 1-7.
8. Kozakiewicz, K., Wrubel, M., Petelenz, I., Lepkowski, A., Skrzypek Wanha, J., & Chrusciel, T. L. (1993). Trimetazidine therapy in atrio-cochlear disturbances of vascular origin. Polski Tygodnik Lekarski, 48, 372-379.
9. Maridonneau-Parini, I. (1986). Effect of trimetazidine on membrane changes induced by oxygen free radicals in human red cells. Presse Medicale, 15, 1762-1764.
10. Oǧuzhanoǧlu, A., & Kurt, T. (2001). Findings of somatosensory evoked potential to stimulation of the sciatic nerve in two different rat strains. Experimental Animals, 50, 361-364.
11. Packer, L., Tritschler, H. J., & Wesse, K. (1997). Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radical Biology & Medicine, 22, 359-378.
12. Paxinos, G., & Watson, C. (1997). The rat brain in stereotaxic coordinates. San Diego: Academic Press.
13. Pulsinelli, W. A., & Brierley, J. B. (1979). A new model of bilateral hemispheric ischemia in the unanesthetized. Stroke, 10, 267-272.
14. Smirnov, A. V., Zarubina, I. V., Krivoruchko, B. I., & Mironova, O. P. (1999). Effect of trimetazidine on the brain metabolism during acute ischemia complicated by hypoxia. Biulleten' Eksperimental'noi Biologii i Meditsiny, 127, 299-301.
15. Suzer, T., Coskun, E., Demir, S., & Tahta, K. (2000). Lipid peroxidation and glutathione levels after cortical injection of ferricchloride in rats: Effect of trimetazidine and deferoxamine. Research in Experimental Medicine, 199, 223-229.
16. Tan, U. (1989). Cerebral somatosensory potentials evoked by posterior tibial nerve stimulation: Lateralization and relation to handedness in left-handed normal subjects. International Journal of Neuroscience, 49, 303-317.
17. Tan, U., Komsuoglu, S., & Akgun, A. (1993). Inverse relationship between the size of pattern reversal visual evoked potentials from the left brain and the degree of left-hand preference in left-handed normal subjects: Importance of the left brain. International Journal of Neuroscience, 72, 79-87.
18. 2 from DNA damage. Free Radical Biology & Medicine, 30, 1357-1364.
19. Villa, R. F., & Gorini, A. (1984). Effect of ischaemia and pharmacological treatment on enzyme activities of cortical mitochondria and synaptosomes. International Journal of Clinical Pharmacology Research., 4, 263-275.
20. Zweier, J. L., Kuppusamy, P., & Lutty, G. A. (1988). Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in postischemic tissues. Proceedings of the National Academy of Sciences of the United States of America, 85, 4046-4050.