Effects of adenovirus-mediated gene transfer of ICOSIg and CTLA4Ig fusion protein on experimental autoimmune myocarditis

Autoimmunity

Volumn 39, Issue 2, 2006, Pages 83-92

  Liu, W ^a   Gao, C ^a   Zhou, B G ^a   Li, W M ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

CTLA 4; EAM; Gene therapy; ICOS; Inflammation

Indexed keywords

ABATACEPT; ADENOVIRUS VECTOR; B7 ANTIGEN; CARDIAC MYOSIN; CD86 ANTIGEN; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; INDUCIBLE COSTIMULATOR IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 4; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CELL ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSPOT ASSAY; GENE TRANSFER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MALE; MYOCARDITIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VIRAL GENE THERAPY; VIRUS EXPRESSION; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; AUTOIMMUNE DISEASES; BASE SEQUENCE; CYTOKINES; DNA, COMPLEMENTARY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNOCONJUGATES; MALE; MYOCARDITIS; RATS; RATS, INBRED LEW; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 33646392480     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930500507870     Document Type: Article

References (28)

1. Hessel, FP and Wegner, C and Muller, J and Glaveris, C and Wasem, J. (2004) Economic evaluation and survival analysis of immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy Eur J Health Econ, 5(1), pp. 58-63.
2. Kono, K. (2005) Autoimmune myocarditis Nippon Rinsho, 63(5), pp. 512-515.
3. Afanasyeva, M and Georgakopoulos, D and Rose, NR. (2004) Autoimmune myocarditis: Cellular mediators of cardiac dysfunction Autoimmun Rev, 3(7-8), pp. 476-486.
4. Van Berkel, ME and Schuijver, EH and Hofhuis, FM and Sharpe, AH and Coyle, AJ and Broeren, CP and Tesselaar, K and Oosterwegel, MA. (2005) ICOS contributes to T cell expansion in ctla-4 deficient mice J Immunol, 175(1), pp. 182-188.
5. Khatlani TS, Ma Z, Okuda M, Inokuma H, Onishi T,(2003)Autoantibodies against T-Cell costimulatory molecules are produced in canine autoimmune diseases J Immunother, 26 (1):12-20
6. Nurieva, RI. (2005) Regulation of immune and autoimmune responses by ICOS-B7h interaction Clin Immunol, 115(1), pp. 19-25.
7. Buckbinder, L and Robinson, RP. (2002) The glucocorticoid receptor: Molecular mechanism and new therapeutic opportunities Curr Drug Targets Inflamm Allergy, 1(2), pp. 127-136.
8. Litzinger, MT and Su, Y and Lei, TC and Soukhareva, N and Scott, DW. (2005) Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction J Immunol, 175(2), pp. 780-787.
9. Chandraker, A and Huurman, V and Hallett, K and Yuan, X and Tector, AJ and Park, CH and Lu, E and Zavazava, N and Oaks, M. (2005) CTLA-4 is important in maintaining long-term survival of cardiac allografts Transplantation, 79(8), pp. 897-903.
10. Zheng, Y and Jost, M and Gaughan, JP and Class, R and Coyle, AJ and Monestier, M. (2005) ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity J Immunol, 174(5), pp. 3117-3121.
11. Shibasaki, F. (2005) Immune anergy in T cell signaling Nippon Rinsho, 63(4), pp. 407-413.
12. Khayyamian, S and Hutloff, A and Buchner, K and Grafe, M and Henn, V and Kroczek, RA and Mages, HW. (2002) ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells Proc Natl Acad Sci USA, 99(9), pp. 6198-6203.
13. Daikh, DI and Wofsy, D. (1999) Effects of anti-B7 monoclonal antibodies on humoral immune responses J Autoimmun, 12(2), pp. 101-108.
14. Kohyama, M and Sugahara, D and Sugiyama, S and Yagita, H and Okumura, K and Hozumi, N. (2004) Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen Proc Natl Acad Sci USA, 101(12), pp. 4192-4197.
15. Padrid, PA and Mathur, M and Li, X and Herrmann, K and Qin, Y and Catmamanchi, A and Weinstock, J and Ellliott, D and Sperling, AI and Bluestone, JA. (1998) CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma Am J Respir Cell Mol Biol, 18(4), pp. 453-462.
16. Matsui, Y and Inobe, M and Okamoto, H and Chiba, S and Shimizu, T and Kitabatake, A and Uede, T. (2002) Blockade of T cell costimulatory signals using adenovirus vectors prevents both the induction and the progression of experimental autoimmune myocarditis J Mol Cell Cardiol, 34(3), pp. 279-295.
17. Sperling, MA. (1997) Aspects of the etiology, prediction, and prevention of insulin-dependent diabetes mellitus in childhood Pediatr Clin North Am, 44(2), pp. 269-284.
18. Sandor, M and Sperling, AI and Cook, GA and Weinstock, JV and Lynch, RG and Bluestone, JA. (1995) Two waves of gamma delta T cells expressing different V delta genes are recruited into schistosome-induced liver granulomas J Immunol, 155(1), pp. 275-284.
19. Dong, C and Nurieva, RI. (2003) Regulation of immune and autoimmune responses by ICOS J Autoimmun, 21(3), pp. 255-260.
20. Kashizuka, H and Sho, M and Nomi, T and Ikeda, N and Kuzumoto, Y and Akashi, S and Tsurui, Y and Mizuno, T and Kanehiro, H and Yagita, H and Nakajima, Y and Sayegh, MH. (2005) Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection Transplantation, 79(9), pp. 1045-1050.
21. Harada, H and Salama, AD and Sho, M and Izawa, A and Sandner, SE and Ito, T and Akiba, H and Yagita, H and Sharpe, AH and Freeman, GJ and Sayegh, MH. (2003) The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity J Clin Invest, 112(2), pp. 234-243.
22. Ozkaynak, E and Gao, W and Shemmeri, N and Wang, C and Gutierrez-Ramos, JC and Amaral, J and Qin, S and Rottman, JB and Coyle, AJ and Hancock, WW. (2001) Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection Nat Immunol, 2(7), pp. 591-596.
23. Vieira, PL and Wassink, L and Smith, LM and Nam, S and Kingsbury, GA and Gutierrez-Ramos, JC and Coyle, AJ and Kapsenberg, ML and Wierenga, EA. (2004) ICOS-mediated signaling regulates cytokine production by human T cells and provides a unique signal to selectively control the clonal expansion of Th2 helper cells Eur J Immunol, 34(5), pp. 1282-1290.
24. Lee, WI and Zhu, Q and Gambineri, E and Jin, Y and Welcher, AA and Ochs, HD. (2003) Inducible costimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis J Allergy Clin Immunol, 112(5), pp. 958-964.
25. Kashizuka, H and Sho, M and Nomi, T and Ikeda, N and Kuzumoto, Y and Akashi, S and Tsurui, Y and Mizuno, T and Kanehiro, H and Yagita, H and Nakajima, Y and Sayegh, MH. (2005) Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection Transplantation, 79(9), pp. 1045-1050.
26. Dong, C and Juedes, AE and Temann, UA and Shresta, S and Allison, JP and Ruddle, NH and Flavell, RA. (2001) ICOS costimulatory receptor is essential for T-cell activation and function Nature, 409(6816), pp. 97-101.
27. Zheng, Y and Jost, M and Gaughan, JP and Class, R and Coyle, AJ and Monestier, M. (2005) ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity J Immunol, 174(5), pp. 3117-3121.
28. Shi, CX and Hitt, M and Ng, P and Graham, FL. (2002) Superior tissue-specific expression from tyrosinase and prostate-specific antigen promoters/enhancers in helper-dependent compared with first-generation adenoviral vectors Hum Gene Ther, 13(2), pp. 211-224.