Assessing genetic effects in survival data by correlating martingale residuals with an application to age at onset of Huntington disease

Statistics in Medicine

Volumn 25, Issue 18, 2006, Pages 3190-3200

  Wintrebert, Claire M A ^a   Zwinderman, Aeilko H ^b   Maat Kievit, Anneke ^c   Roos, Raymund A ^a   van Houwelingen, Hans C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Age at onset; Frailty; Genetic effects; Huntington disease; Martingale residuals

Indexed keywords

ADENINE; CYTOSINE; GUANINE; HUNTINGTIN;

ARTICLE; CHILD PARENT RELATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE CLUSTER; GENETIC ASSOCIATION; GENETIC DISTANCE; GENETIC MODEL; GRANDCHILD; GRANDPARENT; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL COMPUTING; METHODOLOGY; ONSET AGE; PEDIGREE; RELATIVE; SCORING SYSTEM; SIBLING; SURVIVAL RATE; TRINUCLEOTIDE REPEAT;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CHILD; FAMILY; FEMALE; HUMANS; HUNTINGTON DISEASE; INFANT; KAPLAN-MEIER ESTIMATE; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; MODELS, GENETIC; PROPORTIONAL HAZARDS MODELS; TRINUCLEOTIDE REPEATS;

EID: 33748611939     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.2245     Document Type: Article

References (17)

1. Li H, Thompson E. Semi-parametric estimation of major gene and family-specific random effects for age at onset. Biometrics 1997; 53(1):282-293.
2. Korsgaard IR, Andersen AH. The additive genetic gamma frailty model. Scandinavian Journal of Statistics 1998; 25:255-269.
3. Li H. The additive genetic gamma frailty model for linkage analysis of age-of-onset variation. Annals of Human Genetics 1999; 63:455-468.
4. Li H, Zhong X. Multivariate survival models induced by genetic frailties, with application to linkage analysis. Biostatistics 2002; 3:57-75.
5. Cox Dr. Regression models and life tables (with discussion). Journal of the Royal Statistical Society, Series B 1972; 34:187-220.
6. Verweij P, Houwelingen JC, Stijnen T. A goodness-of-fit test for Cox's proportional hazards model based on martingale residuals. Biometrics 1998; 54:1517-1526.
7. Houwing-Duistermaat JJ, Derkx BHF, Rosendaal FR, Houwelingen JC. Testing familial aggregation. Biometrics 1995; 51:1292-1301.
8. Maat-Kievit A, Losekoot M, Zwinderman K, Vegter-van der Vlis M, Belfroid R, Lopez F, van Ommen GJ, Breuning M, Roos R. Predictability of age at onset in Huntington disease in the Dutch population. Medicine 2002; 81(4):251-259.
9. Thompson EA. Pedigree Analysis in Human Genetics. The Johns Hopkins University Press: Baltimore, MD, 1986.
10. Breslow N. Covariance analysis of censored survival data. Biometrics 1974; 30:89-100.
11. Fleming TR, Harrington DP. Counting Processes and Survival Analysis. Wiley: New York, 1991.
12. Elbers C, Ridder G. True and spurious duration dependence: the identifiability of the proportional hazard model. Review of Economic Studies 1982; XLIX:403-409.
13. Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shouson I, Bonilla E, Martin JB. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 1983; 306:234-238.
14. Nance MA, Mathias-Hagen V, Breningstall G, Wick MJ, McGlennan RC. Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease. Neurology 1999; 52:392-394.
15. Rosenblatt A, Brinkman RR, Liang KY, Almqvist EW, Huang CY, Sherr M, Franz L, Abbott MH, Hayden MR, Ross CA. Familial influence on age of onset among siblings with Huntington disease. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2001; 105:399-403.
16. n repeats in parent-offspring pairs with Huntington disease. American Journal of Human Genetics 1995; 57:593-602.
17. Macdonald ME, Vonsattel JP, Shrinidhi J, Couropmitree NN, Cupples LA, Bird ED, Gusella JF, Myers RH. Evidence for the Glu6 gene associated with younger onset age of Huntington's disease. Neurology 1999; 53: 1330-1332.