The additive genetic gamma frailty model for linkage analysis of age-of-onset variation

Annals of Human Genetics

Volumn 63, Issue 5, 1999, Pages 455-468

  Li, Hongzhe ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC MODEL; INHERITANCE; NONBIOLOGICAL MODEL; ONSET AGE; PRIORITY JOURNAL;

AGE FACTORS; AGE OF ONSET; ALGORITHMS; ALLELES; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LOD SCORE; MODELS, GENETIC; MODELS, STATISTICAL; PEDIGREE; VARIATION (GENETICS);

EID: 0033494094     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480099007757     Document Type: Article

References (41)

1. AMOS, C. I. (1994). Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 54, 535-543.
2. BLANGERO, J. & ALMASY, L. (1997). Multipoint oligogenic linkage analysis of quantitative traits. Genet. Epidemiol. 14, 959-964.
3. CAMP, N. J. (1997). Genomewide transmission/disequilibrium testing: consideration of the genotypic relative risks at disease loci. Am. J. Hum. Genet. 61, 1424-1430.
4. CARTER, B. S., BEATY, H. B., STEINBERG, G. D., CHILDS, B. & WALSH, P. C. (1992). Mendelian inheritance of familial prostate cancer. Proc. Natl. Acad. Sc. USA 89, 3367-3371.
5. CLAUS, E. B., RISCH, N. J. & THOMPSON, W. D. (1990). Using age of onset to distinguish between subforms of breast cancer. Ann. Hum. Genet. 54, 169-177.
6. CLAYTON, D. (1978). A model for association in bivariate life tables and its application in epidemiological studies of familial tendency in chronic disease incidence. Biometrika 65, 141-151.
7. CLAYTON, D. & CUZICK, J. (1985). Multivariate generalizations of the proportional hazards model. J. Roy. Stat. Soc. A 148, 82-108.
8. CLERGET-DARPOUX, F., BONAITI-PELLIE, C. & HOCHEZ, J. (1986). Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42, 393-399.
9. COX, D. R. (1972). Regression models and life tables (with discussion). J. Roy. Stat. Soc. B 34, 187-200.
10. DAWSON, D. V., KAPLAN, E. B. & ELSTON, R. C. (1990). Extensions to sib-pair linkage tests applicable to disorders characterized by delayed onset. Genet. Epidemiol. 7, 453-466.
11. DEMPSTER, A. P., LAIRD, N. M. & RUBIN, D. R. (1977). Maximum likelihood estimation from incomplete data via the EM algorithm (with discussion). J. Roy. Stat. Soc. B, 39, 1-38.
12. FLANDERS, W. D. & KHOURY, M. J. (1991). Extension to methods of sib-pair linkage analyses. Genetic Epidemiology 8, 399-408.
13. FLEMING, T. R. & HARRINGTON, D. P. (1991). Counting processes and survival analysis. John Wiley & Sons.
14. GAUDERMAN, W. J. & THOMAS, D. C. (1994). Censored survival models for genetic epidemiology: a Gibbs sampling approach. Genet. Epidemiol. 11, 171-188.
15. GOLDGAR, D. E. (1990). Multipoint analysis of human quantitative genetic variation. Am. J. Hum. Genet. 47, 957-967.
16. HAYNES, C., PERICAK-VANCE, M. A. & DAWSON, D. (1986) Genetic analysis workshop IV: Analysis of Huntington's disease linkage and age of onset curves. Genet. Epidemiol. 1, 109-122.
17. HOUGAARD, P. (1995). Frailty models for survival data. Lifetime Data Analysis 1, 255-273.
18. KORSGAARD, I. R. & ANDERSEN, A. H. (1998). The additive genetic gamma frailty model. Scandinavian J. Stat. 25, 255-269.
19. KRUGLYAK, L., DALY, M. J., REEVE-DALY, M. P. & LANDER E. S. (1996). Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. of Hum. Genet. 58, 1347-1363.
20. LANDER, E. & GREEN, P. (1987). Construction of multilocus genetic maps in humans. Proc. Natl. Acad. Sc. USA 84, 2363-2367.
21. LI, H. (1995). Semiparametric estimation of major gene and random environmental effects for age of onset. Unpublished Ph.D. dissertation, University of Washington.
22. LI, H. & HUANG, J. (1998). Semiparametric linkage analysis using pseudolikelihoods on neighbouring sets. Ann. Hum. Genet., 62, 323-336.
23. LI, H. & THOMPSON, E. A. (1997). Semiparametric estimation of major gene and random familial effects for age of onset. Biometrics 53, 282-293.
24. LI, H., THOMPSON, E. A. & WIJSMAN, E. A. (1998). Semiparametric estimation of major gene effects for age of onset. Genet. Epidemiol., 15, 279-298.
25. MEYER, M. R., TSCHANZ, J. T., NORTON, M. C., WELSH-BOHMER, K. A. et al. (1998). APOE genotype predicts when-not-whether-on is predisposed to develop Alzheimer disease. Nature Genet. 19, 321-322.
26. MORTON, N. E. (1955). Sequential tests for the detection of linkage. Am. J. Hum. Genet. 7, 277-318.
27. MORTON, L. A. & KIDD, K. K. (1980). The effects of variable age-of-onset and diagnostic criteria on the estimates of linkage: An example using manic-depressive illness and color blindness. Soc. Biol. 27, 1-10.
28. NIELSON, G. G., GILL, R. D., ANDERSON, P. K. & SORENSEN, T. I. A. (1992). A counting process approach to maximum likelihood estimation in frailty models. Scandinavian J. of Stat. 19, 25-43.
29. OAKES, D. (1989). Bivariate survival models induced by frailties. J. Am. Stat. Assoc. 84, 487-493.
30. OTT, J. (1991). Analysis of human genetic linkage. The Johns Hopkins University Press.
31. PETERSEN, J. H. (1998 a). A litter frailty model. Technical report, Department of Biostatistics, University of Copenhagen.
32. PETERSEN, J. H. (1998 b). A correlated frailty model. Technical report, Department of Biostatistics, University of Copenhagen.
33. PETERSEN, J. H., ANDERSEN, P. K. & GILL, R. D. (1998). Variance components models for survival data. Statistica Neerlandica 50(1), 193-211.
34. RISCH, N. (1990). Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am. J. Hum. Genet. 46, 229-242.
35. RISCH, N. & MERIKANGAS, K. (1996). The future of genetic studies of complex human diseases. Science 273, 1516-1517.
36. SCHORK, N. J. (1993). Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am. J. Hum. Genet. 53, 1306-1319.
37. SIEGMUND, K. & MCKNIGHT, B. (1998). Modeling hazard functions in families. Genet. Epidemiol. 15, 147-71.
38. VAUPEL, J. M., MANTON, K. G. & STALLARD, E. (1979). The impact of heterogeneity in individual frailty on the dynamics of mortality. Demography 16, 439-454.
39. WEEKS, D. E. & LANGE, K. (1988). The affected-pedigree-member method of linkage analysis. Am. J. Hum. Genet. 42, 315-326.
40. WHITTEMORE, A. S. & HALPERN, J. (1994). Probability of gene identity by descent: computation and applications. Biometrics 50, 109-117.
41. WRIGHT, S. (1922). Coefficients of inbreeding and relationship. American Naturalist, 56, 330-338.