Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations

Hormone and Metabolic Research

Volumn 38, Issue 8, 2006, Pages 518-523

  Nuttall, Frank Q ^a,b   Schweim, K J ^a   Gannon, M C ^a,b,c  

^a VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Amino acids; Glycmic index; Insulin concentration; Phenylalanine; Protein diet

Indexed keywords

AMINO ACID DERIVATIVE; GLUCAGON; GLUCOSE; INSULIN; PHENYLALANINE; WATER;

ADULT; ARTICLE; BODY MASS; DRUG MECHANISM; FEMALE; FLUID INTAKE; GLYCEMIC INDEX; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DIET; TEST MEAL;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; DRUG COMBINATIONS; FEMALE; GLUCAGON; GLUCOSE; HUMANS; INSULIN; MALE; PHENYLALANINE; SWEETENING AGENTS;

EID: 33748607700     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-949523     Document Type: Article

References (20)

1. Fajans SS, Floyd JCJ, Knopf RF, Conn JW. Effect of amino acids and proteins on insulin secretion in man. Recent Prog Horm Res 1967; 23: 617-622
2. Nuttall FQ, Cannon MC. Metabolic response to dietary protein in persons with and without diabetes mellitus. Diabetes Nutr Metab 1991; 4: 71-88
3. Pek S, Fajans SS, Floyd JC Jr., Knopf RF, Conn JW. Effects upon plasma glucagon of infused and ingested amino acids and of protein meals in man. Diabetes 1969; 18: 328 (Abstr. 19).
4. Floyd JC, Fajans SS, Conn JW, Knopf RF, Rull J. Stimulation of insulin secretion by amino acids. J Clin Invest 1966; 45: 1487-1502
5. Muller WA, Aoki TT, Cahill GFJ. Effect of alanine and glycine on glucagon secretion in postabsorptive and fasting obese man. J Clin Endocrinol Metab 1975; 40: 418-425
6. Gannon MC, Nuttall JA, Nuttall FQ. The metabolic response to ingested glycine. Am J Clin Nutr 2002; 76: 1302-1307
7. Gerich JE, Charles MA, Grodsky GM. Regulation of pancreatic insulin and glucagon secretion. Annu Rev Med 1976; 27: 379-388
8. Martinsone D, Ligere R, Martinsons A. The effect of 1-tryptophan load on endocrine system of pancreas in diabetes mellitus. New York: Plenum Press, 1996
9. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1998; 21: S5-S19
10. Nuttall FQ, Cannon MC. Carbohydrates and Diabetes In: Franz MJ, Bantle JP (eds). American Diabetes Association Guide to Medical Nutrition Therapy for Diabetes. Alexandria: American Diabetes Association, 1999; 85-106
11. Cannon MC, Nuttall JA, Nuttall FQ. Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal. Am J Clin Nutr 2002; 76: 1016-1022
12. Nuttall FQ, Cannon MC, Jordan K. The metabolic response to ingestion of proline with and without glucose. Metabolism 2004; 53: 241-246
13. Fennema OR. Food Chemistry. New York: Marcel Dekker Inc., 1985
14. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104: 787-794
15. Floyd JC Jr., Fajans SS, Pek S, Thiffault CA, Knopf RF, Conn JW. Synergistic effect of essential amino acids and glucose upon insulin secretion in man. Diabetes 1970; 19: 109-115
16. Cherrington AD, Stevenson RW, Steiner KE, Davis MA, Myers SR, Adkins BA, Abumrad NN, Williams PE. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev 1987; 3: 307-332
17. Unger RH, Orci L. Physiology and pathophysiology of glucagon. Physiol Rev 1976; 56: 778-826
18. Gannon MC, Nuttall JA, Damberg G, Gupta V, Nuttall FQ. Effect of protein ingestion on the glucose appearance rate in people with type 2 diabetes. J Clin Endocrinol Metab 2001; 86: 1040-1047
19. Saeed A, Jones S, Nuttall FQ, Cannon MC. A fasting-induced decrease in plasma glucose concentration does not affect the insulin response to ingested protein in people with type 2 diabetes. Metabolism 2002; 51: 1027-1033
20. Gannon MC, Nuttall FQ, Saeed A, Jordan K, Hoover H. An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes. Am J Clin Nutr 2003; 78: 734-741