Absence of clastogenic effects of the extract from medicinal plant Rosmarinus officinalis L. on wistar rat bone marrow cells

Cytologia

Volumn 71, Issue 2, 2006, Pages 101-106

  Gaiani, Thamara Figueiredo ^a   Carvalho, José Carlos Tavares ^a   Da Silva, José Mauricio Schneedorf Ferreira ^a   Maistro, Edson Luis ^a  

^a Universidade Jose do Rosario Vellano   (Brazil)

Author keywords

Chromosome aberrations; Clastogenicity; Labiatae; Micronucleus test; Rosmarinus officinalis

Indexed keywords

ANIMALIA; LAMIACEAE; RATTUS NORVEGICUS; ROSMARINUS OFFICINALIS;

EID: 33748606900     PISSN: 00114545     EISSN: 00114545     Source Type: Journal    
DOI: 10.1508/cytologia.71.101     Document Type: Article

References (17)

1. Al-Sereiti, M. R., Abu-Amer, K. M. and Sem, P. 1999. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J. Exp. Biol. 37: 124-130.
2. Collin, M. A. and Charles, H. P. 1987. Antimicrobial activity of carnosol and ursolic acid: two anti-oxidant constituents of Rosmarinus officinalis L. Food Microbiol. 4: 311-315.
3. Esposito, A. V., Pereira, D. M. V., Rocha, L. M., Carvalho, J. C. T. and Maistro, E. L. 2005. Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo. Genet. Mol. Biol. 28: 152-155.
4. Fahim, F. A., Esmat, A. Y., Fadel, H. M. and Hassan, K. F. 1999. Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis. Int. J. Food Sci. Nutr. 50: 413-427.
5. Ford, C. E. and Hamerton, J. L. 1956. A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes. Stain Technol. 31: 247-251.
6. Huang, M. T., Ho, C. T., Wang, Z. Y., Ferraro, T., Lou, Y. R., Stauber, K., Ma, W., Georgiadis, C., Laskin, J. D. and Conney, A. H. 1994. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. 54: 701-708.
7. Lemonica, I. P., Damasceno, D. C. and Di-Stasi, L. C. 1996. Study of the embriotoxic effects of an extract of rosemary (Rosmarinus officinalis L.). Braz. J. Med. Biol. Res. 29: 223-227.
8. Mahmoud, A. A., Al-Shihry, S. S. and Son, B. W. 2005. Diterpenoid quinones from Rosemary (Rosmarinus officinalis L.). Phytochem. 66: 1685-1690.
9. Maistro, E. L., Carvalho, J. C. T. and Mantovani, M. S. 2004. Evaluation of the genotoxic potential of the Casearia sylvestris extract on HTC and V79 cells by the comet assay. Toxicology in Vitro 18: 337-342.
10. Mangena, T. and Muyima, N. Y. 1999. Comparative evaluation of the antimicrobial activities of essential oils of Artemisia afra, Pteronia incana and Rosmarinus officinalis on selected bacteria and yest strains. Lett. Appl. Microbiol. 28: 291-296.
11. Minnunni, M., Wolleb, U., Mueller, O., Pfeifer, A. and Aeschbacher, H. U. 1992. Natural antioxidants as inhibitors of oxygen species induced mutagenicity. Mut. Res. 269: 193-200.
12. Newall, C. A. 1996. Herbal Medicines - A Guide for Health Care Professionals. The Pharmaceutical Press, London, UK.
13. Savage, J. R. K. 1975. Classification and relationships of induced chromosomal structural changes. J. Med. Genetics 12: 103-122.
14. Singletary, K. W. and Nelshoppen, J. M. 1991. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and in vivo formation of mammary DMBA-DNA adducts by rosemary extract. Cancer Lett. 60: 169-175.
15. Schmid, W. 1976. The micronucleous test for cytogenetic analysis. In: Hollaender, A. (ed.). Chemical Mutagenesis, Principles and Methods for their Detection, Vol. 4. Plenum Press, New York, pp. 31-53.
16. Teixeira, R. O., Camparoto, M. L., Mantovani, M. S. and Vicentini, V. E. P. 2003. Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L., in in vitro and in vivo assays. Genet. Mol. Biol. 26: 551-555.
17. Wargovich, M. J., Woods, C., Hollis, D. M. and Zander, M. E. 2001. Herbals, Cancer Prevention and Health. J. Nutr. 131: 3034-3036.