Conjugated linoleic acid reduced metastasized LL2 tumors in mouse peritoneum

Virchows Archiv

Volumn 449, Issue 3, 2006, Pages 341-347

  Sakai, Yasuha ^a   Sasahira, Tomonori ^a   Ohmori, Hitoshi ^a   Yoshida, Kazuhiro ^b   Kuniyasu, Hiroki ^a,c  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c NONE   (Japan)

Author keywords

CLA; Growth inhibition; Metastasis

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CONJUGATED LINOLEIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GROWTH INHIBITION; MOUSE; NONHUMAN; PERITONEAL CAVITY; PERITONEUM METASTASIS; PRIORITY JOURNAL; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; INJECTIONS, INTRAPERITONEAL; LINOLEIC ACIDS, CONJUGATED; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; OLIGONUCLEOTIDES, ANTISENSE; PERITONEAL NEOPLASMS; PPAR GAMMA; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 33748557796     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-006-0249-7     Document Type: Article

References (21)

1. Bassaganya-Riera J, Hontecillas R, Beitz DC (2002) Colonic anti-inflammatory mechanisms of conjugated linoleic acid. Clin Nutr 21:451-459
2. Belury MA (2002) Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr 22:505-531
3. Berger J, Wagner JA (2002) Physiological and therapeutic roles of peroxisome proliferator-activated receptors. Diabetes Technol Ther 4:163-174
4. Bren-Mattison Y, Van Putten V, Chan D, Winn R, Geraci MW, Nemenoff RA (2005) Peroxisome proliferator-activated receptor-γ (PPARγ) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC). Oncogene 24:1412-1422
5. Chen A, Xu J (2004) Activation of PPARγ by curcumin inhibits Moser cell growth and mediates the suppression of the gene expression of cyclinD1 and EGFR. Am J Physiol Gastrointest Liver Physiol 14:14
6. Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, Auwerx J (2001) Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptorγ (PPARγ) heterodimer. A basis for new therapeutic strategies. J Exp Med 193:827-838
7. Duplus E, Forest C (2002) Is there a single mechanism for fatty acid regulation of gene transcription? Biochem Pharmacol 64:893-901
8. Galusca B, Dumollard JM, Chambonniere ML, Germain N, Prades JM, Peoc'h M, Estour B (2004) Peroxisome proliferator activated receptor gamma immunohistochemical expression in human papillary thyroid carcinoma tissues. Possible relationship to lymph node metastasis. Anticancer Res 24:1993-1997
9. Hsi LC, Wilson L, Nixon J, Eling TE (2001) 15-Lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway. J Biol Chem 276:34545-34552
10. Kuniyasu H, Yasui W, Kitahara K, Naka K, Yokozaki H, Akama Y, Hamamoto T, Tahara H, Tahara E (1997) Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line. Cell Growth Differ 8:47-52
11. Kuniyasu H, Yoshida K, Sasaki T, Sasahira T, Fujii K, Ohmori H (2006) Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. Int J Cancer 118:571-576
12. Liu H, Zang C, Fenner MH, Possinger K, Elstner E (2003) PPARγ ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat 79:63-74
13. Liu JJ, Huang RW, Lin DJ, Peng J, Wu XY, Lin Q, Pan XL, Song YQ, Zhang MH, Hou M, Chen F (2005) Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-γ ligands induces apoptosis on human myeloid leukemia cells in vitro. Ann Oncol 16:455-459
14. Majumder B, Wahle KW, Moir S, Schofield A, Choe SN, Farquharson A, Grant I, Heys SD (2002) Conjugated linoleic acids (CLAs) regulate the expression of key apoptotic genes in human breast cancer cells. FASEB J 16:1447-1449
15. McCarty MF (2000) Activation of PPARγ may mediate a portion of the anticancer activity of conjugated linoleic acid. Med Hypotheses 55:187-188
16. Miller A, Stanton C, Devery R (2002) Cis 9, trans 11- and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. Anticancer Res 22:3879-3887
17. Moya-Camarena SY, Belury MA (1999) CLA and PPARγ activation. J Nutr 129:2106
18. Sugarbaker PH (2002) New responsibilities in the management of colorectal cancer with peritoneal seeding. Cancer Investig 20:1118-1122
19. Sugarbaker PH, Yu W, Yonemura Y (2003) Gastrectomy, peritonectomy, and perioperative intraperitoneal chemotherapy: the evolution of treatment strategies for advanced gastric cancer. Sem Surg Oncol 21:233-248
20. Tanaka T, Kohno H, Yoshitani S, Takashima S, Okumura A, Murakami A, Hosokawa M (2001) Ligands for peroxisome proliferator-activated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res 61:2424-2428
21. Yoshizumi T, Ohta T, Ninomiya I, Terada I, Fushida S, Fujimura T, Nishimura G, Shimizu K, Yi S, Miwa K (2004) Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects. Int J Oncol 25:631-639