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Volumn 34, Issue 4, 2006, Pages 348-354

Plasma and synovial fluid concentrations of nimesulide and its main metabolite after a single or repeated oral administration in patients with knee osteoarthritis

Author keywords

Hydroxynimesulide (M1); Nimesulide; Non steroidal anti inflammatory drugs (NSAIDs); Osteoarthritis; Plasma; Synovial fluid

Indexed keywords

DRUG METABOLITE; HYDROXYNIMESULIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

EID: 33748554804     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000603400402     Document Type: Article
Times cited : (9)

References (29)
  • 1
    • 0002977645 scopus 로고    scopus 로고
    • Nimesulide: A well-established cyclooxygenase-2 inhibitor with many other pharmacological properties relevant to inflammatory diseases
    • (Vane JJ, Botting RM, eds). London: William Harvey Press
    • Bennett A: Nimesulide: a well-established cyclooxygenase-2 inhibitor with many other pharmacological properties relevant to inflammatory diseases. In: Therapeutic Roles of Selective COX-2 Inhibitors (Vane JJ, Botting RM, eds). London: William Harvey Press, 2001; pp524-540.
    • (2001) Therapeutic Roles of Selective COX-2 Inhibitors , pp. 524-540
    • Bennett, A.1
  • 2
    • 84875974090 scopus 로고    scopus 로고
    • Nimesulide
    • Rainsford KD (ed): Basel: Birkhäuser
    • Rainsford KD (ed): Nimesulide. Actions and Uses. Basel: Birkhäuser, 2005.
    • (2005) Actions and Uses
  • 3
    • 0028122558 scopus 로고
    • Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy
    • Davis R, Brogden RN: Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 1994; 48: 431-454.
    • (1994) Drugs , vol.48 , pp. 431-454
    • Davis, R.1    Brogden, R.N.2
  • 4
    • 0035065741 scopus 로고    scopus 로고
    • Nimesulide, a balanced drug for the treatment of osteoarthritis
    • Huskisson EC: Nimesulide, a balanced drug for the treatment of osteoarthritis. Clin Exp Rheumatol 2001; 19 (Suppl 22): S21-S25.
    • (2001) Clin Exp Rheumatol , vol.19 , Issue.SUPPL. 22
    • Huskisson, E.C.1
  • 5
    • 0038722280 scopus 로고    scopus 로고
    • A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee
    • Bianchi M, Broggini M: A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee. Drugs 2003; 63 (Suppl 1): 37-46.
    • (2003) Drugs , vol.63 , Issue.SUPPL. 1 , pp. 37-46
    • Bianchi, M.1    Broggini, M.2
  • 6
    • 0031753851 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of nimesulide
    • Bernareggi A: Clinical pharmacokinetics of nimesulide. Clin Pharmacokinet 1998; 35: 247-274.
    • (1998) Clin Pharmacokinet , vol.35 , pp. 247-274
    • Bernareggi, A.1
  • 7
    • 0023877589 scopus 로고
    • Simultaneous determination of nimesulide and hydroxynimesulide in human plasma and urine by high-performance liquid chromatography
    • Castoldi D, Monzani V, Tofanetti O: Simultaneous determination of nimesulide and hydroxynimesulide in human plasma and urine by high-performance liquid chromatography. J Chromatogr 1988; 425: 413-418.
    • (1988) J Chromatogr , vol.425 , pp. 413-418
    • Castoldi, D.1    Monzani, V.2    Tofanetti, O.3
  • 8
    • 0027362696 scopus 로고
    • The pharmacokinetic profile of nimesulide in healthy volunteers
    • Bernareggi A: The pharmacokinetic profile of nimesulide in healthy volunteers. Drugs 1993; 46 (Suppl 1): 64-72.
    • (1993) Drugs , vol.46 , Issue.SUPPL. 1 , pp. 64-72
    • Bernareggi, A.1
  • 9
    • 0027436245 scopus 로고
    • Anti-oxidant activity of nimesulide and its main metabolite
    • Maffei-Facino R, Carini M, Aldini G: Anti-oxidant activity of nimesulide and its main metabolite. Drugs 1993; 46 (Suppl 1): 15-21.
    • (1993) Drugs , vol.46 , Issue.SUPPL. 1 , pp. 15-21
    • Maffei-Facino, R.1    Carini, M.2    Aldini, G.3
  • 10
    • 0000292489 scopus 로고
    • La nimesulide nel liquido sinoviale di pazienti con artrite reumatoide
    • Lignière GC, Tamborini U, Panarace G: La nimesulide nel liquido sinoviale di pazienti con artrite reumatoide. Farmaci e Terapia 1990; 7: 173-176.
    • (1990) Farmaci E Terapia , vol.7 , pp. 173-176
    • Lignière, G.C.1    Tamborini, U.2    Panarace, G.3
  • 11
    • 0038722286 scopus 로고    scopus 로고
    • 2 production by nimesulide compared with diclofenac in the acutely inflamed joints of patients with arthritis
    • 2 production by nimesulide compared with diclofenac in the acutely inflamed joints of patients with arthritis. Drugs 2003; 63 (Suppl 1): 31-36.
    • (2003) Drugs , vol.63 , Issue.SUPPL. 1 , pp. 31-36
    • Duffy, T.1    Belton, O.2    Bresnihan, B.3    Fitzgerald, O.4    Fitzgerald, D.5
  • 12
    • 0024421547 scopus 로고
    • Recent findings on the pharmacodynamics of non-steroidal anti-inflammatory drugs in synovial fluid
    • Netter P, Bannwarth B, Royer-Morrot MJ: Recent findings on the pharmacodynamics of non-steroidal anti-inflammatory drugs in synovial fluid. Clin Pharmacokinet 1989; 17: 145-162.
    • (1989) Clin Pharmacokinet , vol.17 , pp. 145-162
    • Netter, P.1    Bannwarth, B.2    Royer-Morrot, M.J.3
  • 13
    • 0023506743 scopus 로고
    • Criteria for classification of osteoarthritis of the knee and hip
    • Altman RD: Criteria for classification of osteoarthritis of the knee and hip. Scand J Rheumatol Suppl 1987; 65: 31-39.
    • (1987) Scand J Rheumatol Suppl , vol.65 , pp. 31-39
    • Altman, R.D.1
  • 14
    • 0037420197 scopus 로고    scopus 로고
    • Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction
    • Ferrario P, Bianchi M: Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci 2003; 785: 227-236.
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.785 , pp. 227-236
    • Ferrario, P.1    Bianchi, M.2
  • 15
    • 0027089768 scopus 로고
    • Effectiveness and tolerability of nimesulide in the treatment of osteoarthritic elderly patients
    • Blardi P, Gatti F, Auteri A, Di Perri T: Effectiveness and tolerability of nimesulide in the treatment of osteoarthritic elderly patients. Int J Tissue React 1992; 14: 263-268.
    • (1992) Int J Tissue React , vol.14 , pp. 263-268
    • Blardi, P.1    Gatti, F.2    Auteri, A.3    Di Perri, T.4
  • 16
    • 0028075866 scopus 로고
    • Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis
    • Bourgeois P, Dreiser RL, Lequesne MG, Macciocchi A, Monti T. Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. Eur J Rheum Inflamm 1994; 14: 39-50.
    • (1994) Eur J Rheum Inflamm , vol.14 , pp. 39-50
    • Bourgeois, P.1    Dreiser, R.L.2    Lequesne, M.G.3    Macciocchi, A.4    Monti, T.5
  • 17
    • 0028657660 scopus 로고
    • Double-blind study evaluating by endoscopy the tolerability of nimesulide and diclofenac on the gastric mucosa in osteoarthritic patients
    • Porto A, Almeida H, Cunha MJ, Macciocchi A: Double-blind study evaluating by endoscopy the tolerability of nimesulide and diclofenac on the gastric mucosa in osteoarthritic patients. Eur J Rheumatol Inflamm 1994; 14: 33-38.
    • (1994) Eur J Rheumatol Inflamm , vol.14 , pp. 33-38
    • Porto, A.1    Almeida, H.2    Cunha, M.J.3    Macciocchi, A.4
  • 18
    • 0032727572 scopus 로고    scopus 로고
    • Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide
    • Wober W: Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide. Rheumatology 1999; 38 (Suppl 1): 33-38.
    • (1999) Rheumatology , vol.38 , Issue.SUPPL. 1 , pp. 33-38
    • Wober, W.1
  • 19
    • 0032957179 scopus 로고    scopus 로고
    • Nimesulide versus diclofenac in the treatment of osteoathritis of the hip or knee: An active controlled equivalence study
    • Huskisson EC, Macciocchi A, Rahlfs VW, Bernstein RM, Bremner AD, Doyle DV, et al: Nimesulide versus diclofenac in the treatment of osteoathritis of the hip or knee: an active controlled equivalence study. Curr Ther Res 1999; 60: 253-265.
    • (1999) Curr Ther Res , vol.60 , pp. 253-265
    • Huskisson, E.C.1    Macciocchi, A.2    Rahlfs, V.W.3    Bernstein, R.M.4    Bremner, A.D.5    Doyle, D.V.6
  • 20
    • 0032776282 scopus 로고    scopus 로고
    • Comparative efficacy and safety of nimesulide versus piroxicam in osteoarthritis with special reference to chondroprotectian
    • Sharma S, Rastogi S, Gupta V, Rohtagi D, Gulati P: Comparative efficacy and safety of nimesulide versus piroxicam in osteoarthritis with special reference to chondroprotectian. Am J Ther 1999; 6: 191-197.
    • (1999) Am J Ther , vol.6 , pp. 191-197
    • Sharma, S.1    Rastogi, S.2    Gupta, V.3    Rohtagi, D.4    Gulati, P.5
  • 21
    • 0034755794 scopus 로고    scopus 로고
    • Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis
    • Kriegel W, Korff KJ, Ehrlich JC, Lehnhardt K, Macciocchi A, Moresino C, et al: Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. Int J Clin Pract 2001; 55: 510-514.
    • (2001) Int J Clin Pract , vol.55 , pp. 510-514
    • Kriegel, W.1    Korff, K.J.2    Ehrlich, J.C.3    Lehnhardt, K.4    Macciocchi, A.5    Moresino, C.6
  • 22
    • 0020504744 scopus 로고
    • Anti-prostaglandin and anti-inflammatory short-term efficacy of piroxicam in rheumatoid arthritis
    • Strusberg A, Montrull H, Meirovich CI: Anti-prostaglandin and anti-inflammatory short-term efficacy of piroxicam in rheumatoid arthritis. Eur J Rheumatol Inflamm 1983; 6: 41-45.
    • (1983) Eur J Rheumatol Inflamm , vol.6 , pp. 41-45
    • Strusberg, A.1    Montrull, H.2    Meirovich, C.I.3
  • 24
    • 33748555333 scopus 로고
    • Synovial tissue, synovial fluid, and plasma distribution of nonsteroidal anti-inflammatory drugs: Clinical implications
    • Borenstein D: Synovial tissue, synovial fluid, and plasma distribution of nonsteroidal anti-inflammatory drugs: clinical implications. Am J Ther 1995; 2: 978-983.
    • (1995) Am J Ther , vol.2 , pp. 978-983
    • Borenstein, D.1
  • 25
    • 0034468514 scopus 로고    scopus 로고
    • Pharmacological basis for the therapy of pain and inflammation with non-steroidal anti-inflammatory drugs
    • Steinmeyer J: Pharmacological basis for the therapy of pain and inflammation with non-steroidal anti-inflammatory drugs. Arthritis Res 2000; 2: 379-385.
    • (2000) Arthritis Res , vol.2 , pp. 379-385
    • Steinmeyer, J.1
  • 26
    • 0036156424 scopus 로고    scopus 로고
    • Cyclooxygenase-2 - 10 years later
    • Hinz B, Brune K: Cyclooxygenase-2 - 10 years later. J Pharmacol Exp Ther 2002; 300: 367-375.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 367-375
    • Hinz, B.1    Brune, K.2
  • 27
    • 0035943371 scopus 로고    scopus 로고
    • Cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs in humans: Ex vivo evaluation
    • Giuliano F, Ferraz JG, Pereira R, de Nucci G, Warner TD: Cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs in humans: ex vivo evaluation, Eur J Pharmacol 2001; 426: 95-103.
    • (2001) Eur J Pharmacol , vol.426 , pp. 95-103
    • Giuliano, F.1    Ferraz, J.G.2    Pereira, R.3    de Nucci, G.4    Warner, T.D.5
  • 28
    • 0034999762 scopus 로고    scopus 로고
    • Is there a rationale for the use of nimesulide in the treatment of dysmenorrhoea?
    • Pulkkinen MO: Is there a rationale for the use of nimesulide in the treatment of dysmenorrhoea? Drugs Today 2001; 37 (Suppl B): 31-38.
    • (2001) Drugs Today , vol.37 , Issue.SUPPL. B , pp. 31-38
    • Pulkkinen, M.O.1
  • 29
    • 0035984658 scopus 로고    scopus 로고
    • Anti-hyperalgesic effects of nimesulide: Studies in rats and humans
    • Bianchi M, Broggini M: Anti-hyperalgesic effects of nimesulide: Studies in rats and humans. Int J Clin Practice 2002; 128 (Suppl): 11-19.
    • (2002) Int J Clin Practice , vol.128 , Issue.SUPPL. , pp. 11-19
    • Bianchi, M.1    Broggini, M.2


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