Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 785, Issue 2, 2003, Pages 227-236

  Ferrario, Paolo ^a   Bianchi, Mauro ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Hydroxynimesulide; Nimesulide

Indexed keywords

BRAIN; EXTRACTION; PLASMA DIAGNOSTICS; SODIUM COMPOUNDS; ULTRAVIOLET DETECTORS;

RAT PLASMAS;

LIQUID CHROMATOGRAPHY;

ACETONITRILE; CITRATE SODIUM; DRUG METABOLITE; HYDROXYNIMESULIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; BRAIN TISSUE; CALIBRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DETERMINATION; DRUG ISOLATION; FLOW RATE; LIQUID CHROMATOGRAPHY; MALE; MODULATION; NONHUMAN; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; ROOM TEMPERATURE; SOLID PHASE EXTRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CALIBRATION; CHROMATOGRAPHY, LIQUID; LINEAR MODELS; MALE; RATS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFONAMIDES;

EID: 0037420197     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00857-7     Document Type: Article

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