A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

Journal of Medicinal Chemistry

Volumn 49, Issue 18, 2006, Pages 5404-5407

  Kinzel, Olaf ^a   Fattori, Daniela ^a   Muraglia, Ester ^a   Gallinari, Paola ^a   Nardi, Maria Chiara ^a   Paolini, Chantal ^a   Roscilli, Giuseppe ^a   Toniatti, Carlo ^a   Gonzalez Paz, Odalys ^a   Laufer, Ralph ^a   Lahm, Armin ^a   Tramontano, Anna ^a   Cortese, Riccardo ^a   De Francesco, Raffaele ^a   Ciliberto, Gennaro ^a   Koch, Uwe ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ANTIESTROGEN; ESTROGEN RECEPTOR; FLUORENONE DERIVATIVE; LIGAND; MUTANT PROTEIN; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TETRAHYDROFLUORENONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COEVOLUTION; DRUG DESIGN; GENE SWITCHING; IN VIVO STUDY; LIGAND BINDING; MOLECULAR LIBRARY; NONHUMAN; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORENES; HELA CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748551040     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060516e     Document Type: Article

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