Columnar Cell Lesions and Flat Epithelial Atypia of the Breast

Seminars in Breast Disease

Volumn 8, Issue 2, 2005, Pages 100-111

  Schnitt, Stuart J ^a   Collins, Laura C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

atypical ductal hyperplasia; breast; columnar cell; ductal carcinoma in situ; flat epithlelial atypia; lobular neoplasia; tubular carcinoma

Indexed keywords

ARTICLE; BREAST BIOPSY; BREAST CALCIFICATION; BREAST CANCER; BREAST LESION; CANCER CLASSIFICATION; CANCER GROWTH; CARCINOMA IN SITU; CELL HYPERPLASIA; COLUMNAR EPITHELIUM; CYTODIAGNOSIS; DIFFERENTIAL DIAGNOSIS; DUCTAL CARCINOMA IN SITU; FLAT EPITHELIAL ATYPIA; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; MAMMOGRAPHY; PRIORITY JOURNAL; REPRODUCIBILITY; TUBULAR CARCINOMA; TUMOR GROWTH; WORLD HEALTH ORGANIZATION;

EID: 33748549598     PISSN: 10924450     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.sembd.2006.06.007     Document Type: Article

References (54)

1. Page D.L., and Anderson T.J. Diagnostic Histopathology of the Breast (1987), Churchill Livingstone, Edinburgh
2. Bonser G.M., Dossett J.A., and Jull W. Human and Experimental Breast Cancer (1961), Pitman Medical, London
3. Trojani M. Atlas en couleurs d'histopathologie mammaire (1988), Maloine, Paris
4. Foote Jr. F.W., and Stewart F.W. Comparative studies of cancerous vs. non-cancerous breasts. Basic morphological characteristics. Ann Surg 121 (1945) 6-53
5. Azzopardi J.G. Problems in Breast Pathology (1979), WB Saunders, Philadelphia, PA
6. Gallager H.S. Sources of uncertainty in interpretation of breast biopsies. Breast 2 (1976) 12-15
7. Wellings S.R., Jensen H.M., and Marcum R.G. An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst 55 (1975) 231-273
8. Oyama T., Iijima K., Takei H., et al. Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. Breast Cancer 7 (2000) 326-331
9. Tsuchiya S. Atypical ductal hyperplasia, atypical lobular hyperplasia, and interpretation of a new borderline lesion. Jpn J Cancer Clin 44 (1998) 548-555
10. Rosen P.P. Rosen's Breast Pathology. (ed 2) (2001), Lippincott-Raven, Philadelphia, PA
11. Rosen P.P. Columnar cell hyperplasia is associated with lobular carcinoma in situ and tubular carcinoma. Am J Surg Pathol 23 (1999) 1561
12. Goldstein N.S., and O'Malley B.A. Cancerization of small ectatic ducts of the breast by ductal carcinoma in situ cells with apocrine snouts: a lesion associated with tubular carcinoma. Am J Clin Pathol 107 (1997) 561-566
13. Page D.L.K.M., and Jensen R.A. Hypersecretory hyperplasia with atypia in breast biopsies. What is the proper level of clinical concern? Pathol Case Rev 1 (1996) 36-40
14. Fraser J.L., Raza S., Chorny K., et al. Columnar alteration with prominent apical snouts and secretions: a spectrum of changes frequently present in breast biopsies performed for microcalcifications. Am J Surg Pathol 22 (1998) 1521-1527
15. Moinfar F., Man Y.G., Bratthauer G.L., et al. Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ("clinging ductal carcinoma in situ"): a simulator of normal mammary epithelium. Cancer 88 (2000) 2072-2081
16. Lee S., Mohsin S.K., Mao S., et al. Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer. Breast Cancer Res 8 (2000) R6
17. McLaren B.K., Gobbi H., Schuyler P.A., et al. Immunohistochemical expression of estrogen receptor in enlarged lobular units with columnar alteration in benign breast biopsies: a nested case-control study. Am J Surg Pathol 29 (2005) 105-108
18. Mohsin S.K., Allred D.C., Osborne C.K., et al. Morphologic and immunophenotypic markers as surrogate endpoints of tamoxifen effect for prevention of breast cancer. Breast Cancer Res Treat 94 (2005) 205-211
19. Arpino G., Laucirica R., and Elledge R.M. Premalignant and in situ breast disease: biology and clinical implications. Ann Intern Med 143 (2005) 446-457
20. Schnitt S.J. The diagnosis and management of pre-invasive breast disease: flat epithelial atypia-classification, pathologic features and clinical significance. Breast Cancer Res 5 (2003) 263-268
21. Schnitt S.J. Columnar cell lesions of the breast: pathologic features and clinical significance. Current Diag Pathol 10 (2004) 193-203
22. Nasser S.M. Columnar cell lesions: current classification and controversies. Semin Diagn Pathol 21 (2004) 18-24
23. Tavassoli F.A., Hoefler H., Rosai J., et al. Intraductal proliferative lesions. In: Tavassoli F.A., and Devilee P. (Eds). Pathology and Genetics: Tumours of the Breast and Female Genital Organs (2003), IARC Press, Lyon 63-73
24. Schnitt S.J., and Vincent-Salomon A. Columnar cell lesions of the breast. Adv Anat Pathol 10 (2003) 113-124
25. McBoyle M.F., Razek H.A., Carter J.L., et al. Tubular carcinoma of the breast: an institutional review. Am Surg 63 (1997) 639-644 discussion 44-45
26. Eusebi V., Feudale E., Foschini M.P., et al. Long-term follow-up of in situ carcinoma of the breast. Semin Diagn Pathol 11 (1994) 223-235
27. Simpson P.T., Gale T., Reis-Filho J.S., et al. Columnar cell lesions of the breast: the missing link in breast cancer progression?: a morphological and molecular analysis. Am J Surg Pathol 29 (2005) 734-746
28. Mohsin S., Badve S., Bose S., et al. Assessment of variability in diagnosing "atypia" in columnar cell lesions (CCL) of the breast. Lab Invest 85 suppl 1 (2005) 44A
29. O'Malley F.P., Mohsin S.K., Badve S., et al. Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breast. Mod Pathol 19 (2006) 172-179
30. Tan P.H., Ho B.C., Selvarajan S., et al. Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility?. J Clin Pathol 58 (2005) 705-709
31. Oyama T., Maluf H., and Koerner F. Atypical cystic lobules: an early stage in the formation of low-grade ductal carcinoma in situ. Virchows Arch 435 (1999) 413-421
32. Otterbach F., Bankfalvi A., Bergner S., et al. Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology 37 (2000) 232-240
33. Carlo V., Fraser J., Pliss N., et al. Can absence of high molecular weight cytokeratin expression be used as a marker of atypia in columnar cell lesions of the breast?. Mod Pathol 16 (2003) 24A
34. Raju U., Ornsby A., Ma C., et al. Columnar cell changes in breast: when are they atypical?. An immunohistochemical study of cytokeratin 5/6 (CK5/6) and hormone receptor expression. Lab Invest 17 suppl 1 (2004) 46A
35. Moinfar F., Man Y.G., Lininger R.A., et al. Use of keratin 35betaE12 as an adjunct in the diagnosis of mammary intraepithelial neoplasia-ductal type-benign and malignant intraductal proliferations. Am J Surg Pathol 23 (1999) 1048-1058
36. Fraser J.L.R.S., Chorny K., Connolly J.L., et al. Immunophenotype of columnar alteration with prominent apical snouts and secretions (CAPSS). Lab Invest 80 (2000) 21A
37. Allred D.C., Mohsin S.K., and Fuqua S.A. Histological and biological evolution of human premalignant breast disease. Endocr Relat Cancer 8 (2001) 47-61
38. Dabbs D.J., Kessinger R.L., McManus K., et al. Biology of columnar cell lesions in core biopsies of the breat. Mod Pathol 16 (2003) 26A
39. Tremblay G., Deschenes J., Alpert L., et al. Overexpression of estrogen receptors in columnar cell change and in unfolding breast lobules. Breast J 11 (2005) 326-332
40. Dabbs D.J., Carter G., Fudge M., et al. Molecular alterations in columnar cell lesions of the breast. Mod Pathol 19 (2006) 344-349
41. Dupont W.D., and Page D.L. Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med 312 (1985) 146-151
42. Page D.L., Dupont W.D., Rogers L.W., et al. Atypical hyperplastic lesions of the female breast. A long-term follow-up study. Cancer 55 (1985) 2698-2708
43. Page D.L., and Rogers L.W. Combined histologic and cytologic criteria for the diagnosis of mammary atypical ductal hyperplasia. Hum Pathol 23 (1992) 1095-1097
44. Weidner N. Malignant breast lesions that may mimic benign tumors. Semin Diagn Pathol 12 (1995) 2-13
45. Sahoo S., and Recant W.M. Triad of columnar cell alteration, lobular carcinoma in situ, and tubular carcinoma of the breast. Breast J 11 (2005) 140-142
46. Brogi E., Oyama T., and Koerner F.C. Atypical cystic lobules in patients with lobular neoplasia. Int J Surg Pathol 9 (2001) 201-206
47. Page D., Dupont W.D., and Rogers L.W. Breast cancer risk of lobular-based hyperplasia after biopsy: "ductal" pattern lesions. Cancer Detect Prev 9 (1996) 441-448
48. Shaaban A.M., Sloane J.P., West C.R., et al. Histopathologic types of benign breast lesions and the risk of breast cancer: case-control study. Am J Surg Pathol 26 (2002) 421-430
49. Bijker N., Peterse J.L., Duchateau L., et al. Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853. J Clin Oncol 19 (2001) 2263-2271
50. de Mascarel I., MacGrogan G., Picot V., et al. Results of a long term follow-up study of 115 patients with flat epithelial atypia. Lab Invest 86 suppl 1 (2006) 25A
51. Brogi E., and Tan L.K. Findings at excisional biopsy (EBX) performed after identification of columnar cell change (CCC) of ductal epithelium in breast core biopsy (CBX). Mod Pathol 15 (2002) 29A-30A (abstract)
52. Harigopal M.Y.D., Hoda S.A., DeLellis R.A., et al. Columnar cell alteration diagnosed on mammotome core biopsy for indeterminate microcalcifications: results of subsequent mammograms and surgical excision. Mod Pathol 15 (2002) 36A
53. Nasser S., and Fan M.J. Does atypical columnar cell hyperplasia on breast core biopsy warrant follow-up excision?. Mod Pathol 16 (2003) 42A
54. Kunju L.P., and Kleer C.G. Significance of flat epithelial atypia (FEA) on mammotome core needle biopsy: should it be excised?. Lab Invest 86 suppl 1 (2006) 32A