Flat epithelial atypia - Classification, pathologic features and clinical significance

Breast Cancer Research

Volumn 5, Issue 5, 2003, Pages 263-268

  Schnitt, Stuart J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Atypia; Breast; Columnar cell; Ductal carcinoma in situ; Flat

Indexed keywords

BIOLOGICAL MARKER;

BREAST DUCT; CANCER CLASSIFICATION; CANCER GROWTH; CANCER RECURRENCE; CARCINOMA IN SITU; CELL SHAPE; CLINICAL FEATURE; CLINICAL OBSERVATION; CYTOPATHOLOGY; EPITHELIUM CELL; FOLLOW UP; HISTOPATHOLOGY; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; PRECANCER; REVIEW; RISK ASSESSMENT; BREAST; BREAST TUMOR; CANCER INVASION; CLASSIFICATION; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HYPERPLASIA; PATHOLOGY;

BREAST; BREAST NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; EPITHELIAL CELLS; FEMALE; HUMANS; HYPERPLASIA; NEOPLASM INVASIVENESS;

EID: 0043142421     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr625     Document Type: Review

References (21)

1. Tavassoli FA, Hoefler H, Rosai J, Holland R, Ellis I, Schnitt S, Lakhani, BR, Boecker W, Heywang-Kobrunner SH, Moinfar F, Peterse J: Intraductal proliferative lesions. In: Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Edited by Tavassoli FA, Devilee P. Lyon: IARC Press; in press.
2. Tsuchiya S: Atypical ductal hyperplasia, atypical lobular hyperplasia, and interpretation of a new borderline lesion. Jpn J Cancer Clin 1998, 44:548-555.
3. Oyama T, Iijima K, Takei H, Horiguchi J, Iino Y, Nakajima T, Koerner F: Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. Breast Cancer 2000, 7: 326-331.
4. Wellings SR, Jensen HM, Marcum RG: An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst 1975, 55:231-273.
5. Azzopardi JG: Problems in Breast Pathology. Philadelphia, PA: WB Saunders; 1979.
6. Eusebi V, Feudale E, Foschini MP, Micheli A, Conti A, Riva C, DiPalma S, Rilke F: Long-term follow-up of in situ carcinoma of the breast. Semin Diagn Pathol 1994, 11:223-235.
7. Fraser JL, Raza S, Chorny K, Connolly JL, Schnitt SJ: Columnar alteration with prominent apical snouts and secretions: a spectrum of changes frequently present in breast biopsies performed for microcalcifications. Am J Surg Pathol 1998, 22: 1521-1527.
8. Moinfar F, Man YG, Bratthauer GL, Ratschek M, Tavassoli FA: Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ('clinging ductal carcinoma in situ'): a simulator of normal mammary epithelium. Cancer 2000; 88:2072-2081.
9. Page DL, Kasami M, Jensen RA: Hypersecretory hyperplasia with atypia in breast biopsies. What is the proper level of clinical concern? Pathol Case Rev 1996, 1:36-40.
10. Rosen PP: Columnar cell hyperplasia is associated with lobular carcinoma in situ and tubular carcinoma [letter]. Am J Surg Pathol 1999, 23:1561.
11. Goldstein NS, O'Malley BA: Cancerization of small ectatic ducts of breast by ductal carcinoma in situ cells with apocrine snouts: a lesion associated with tubular carcinoma. Am J Clin Pathol 1997, 107:561-566.
12. Schnitt SJ, Vincent-Salomon A: Columnar cell lesions of the breast. Adv Anat Pathol 2003, 10:113-124.
13. Oyama T, Maluf H, Koerner F: Atypical cystic lobules: an early stage in the formation of low-grade ductal carcinoma in situ. Virchows Arch 1999, 435:413-421.
14. Otterbach F, Bankfalvi A, Bergner S, Decker T, Krech R, Boecker W: Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology 2000, 37:232-240.
15. Fraser JL, Raza S, Chorny K, Connolly JL, Schnitt SJ: Immunophenotype of columnar alteration with prominent apical snouts and secretions (CAPSS) [abstract]. Lab Invest 2000, 80:21 A.
16. Allred DC, Mohsin SK, Fuqua SA: Histological and biological evolution of human premalignant breast disease. Endocr Relat Cancer 2001, 8:47-61.
17. Weidner N: Malignant breast lesions that may mimic benign tumors. Semin Diagn Pathol 1995, 12:2-13.
18. Rosen PP: Rosen's Breast Pathology. Philadelphia, PA: Lippincott-Raven; 2001.
19. Bijker N, Peterse JL, Duchateau L, Julien JP, Fentiman IS, Duval C, DiPalma S, Simony-Lafontaine J, de Mascarel I, van de Vijver M: Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853. J Clin Oncol 2001, 19:2263-2271.
20. Brogi E, Tan LK: Findings at excisional biopsy (EBX) performed after identification of columnar cell change (CCC) of ductal epithelium in breast core biopsy (CBX) [abstract]. Mod Pathol 2002, 15:29A-30A.
21. Harigopal M, Yao DX, Hoda SA, DeLellis RA, Vazquez MF: Columnar cell alteration diagnosed on mammotome core biopsy for indeterminate microcalcifications: results of subsequent mammograms and surgical excision [abstract]. Mod Pathol 2002, 15:36A.