Evaluation of toxicity of methyl tert-butyl ether (MTBE) on mouse spermatogenic cells in vitro

Toxicology and Industrial Health

Volumn 22, Issue 7, 2006, Pages 291-299

  Li, Dm ^a   Han, Xd ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

apoptosis; DNA; methyl tert butyl ether (MTBE); spermatogenic cells; toxicity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; FLUORESCEIN DIACETATE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROPIDIUM IODIDE; TERT BUTYL METHYL ETHER;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL ISOLATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DETERMINATION; ENVIRONMENTAL EXPOSURE; FLOW CYTOMETRY; IN VITRO STUDY; INCUBATION TIME; MALE; MOUSE; NONHUMAN; QUANTITATIVE ASSAY; SPERMATOCYTE; STAINING;

ANIMALS; CARCINOGENS; CELLS, CULTURED; FLOW CYTOMETRY; MALE; METHYL ETHERS; MICE; MICE, INBRED ICR; SPERMATOGENESIS;

EID: 33748519869     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233706070310     Document Type: Article

References (35)

1. Adami, H. O., Bergstrom, R., Mohner, M. et al. 1994: Testicular cancer in nine Northern European countries. International Journal of Cancer 59, 33-38.
2. Ahmed, F. E. 2001: Toxicology and human health effects following exposure to oxygenated or reformulated gasoline. Toxicology Letters 123, 89-113.
3. Amberg, A., Rosner, E. and Dekant, W. 1999: Biotrans-formation and kinetics of excretion of methyl tert-butyl ether in rats and humans. Toxicological Sciences 51, 1-8.
4. Aravindan, G. R., Pineau, C. P., Bardin, C. W. and Cheng, C. Y. 1996: Ability of trypsin in mimicking germ cell factors that affect Sertoli cell secretory function. Journal of Cellular Physiology 168, 123-133.
5. Auger, J., Kunstmann, J. M., Czyglik, F. and Jouannet, P. 1995: Decline in semen quality among fertile men in Paris during the past 20 years. New England Journal of Medicine 332, 281-285.
6. Belpoggi, F., Soffritti, M. and Maltoni, C. 1995: Methyl-tertiary-butyl ether (MTBE) - a gasoline additive - causes testicular and lymphohaematopoietic cancers in rats. Toxicology and Industrial Health 11, 119-149.
7. Belpoggi, F., Soffritti, M., Filippini, F. and Maltoni, C. 1997: Results of long term experimental studies on the carcinogenicity of methyl-tert-butyl ether (MTBE). Annals of the New York Academy of Sciences 837, 77-95.
8. Bird, M. G., Burleigh-Flayer, H., Chun, J. S. et al. 1997: Oncogenicity study of inhaled methyl tertiary -butyl ether (MTBE) in CD-1 mice and F-344 rats. Journal of Applied Toxicology 17, S45-S55.
9. Borghoff, S. J. and Williams, T. M. 2000: Species-specific tumor responses following exposure to methyl tert -butyl ether. CIIT Activities 20, 1-9.
10. Bosl, G. J. and Motzer, R. J. 1997: Testicular germ-cell cancer. New England Journal of Medicine 337, 242-253.
11. Carlsen, E., Giwercman, A., Keiding, N. and Skakkebaek, N. E. 1992: Evidence for decreasing quality of semen during past 50 years. British Medical Journal 305, 609-613.
12. Clegg, E. D., Cook, J. C., Chapin, R. E. et al. 1997: Leydig cells hyperplasia and adenoma formation: mechanisms and relevance to human. Reproductive Toxicology 11, 107-121.
13. Energy Information Administration (EIA). 2003: Status and impact of state MTBE bans, Washington, DC. US Department of Energy, March 2003 revision. Retrieved 5 December 2003, from http://www.tonto.eia.doe.gov/FTPROOT/service/mtbe.pdf.
14. Faulk, R. O. and Gray J. S. 2001: Salem revisited: updating the MTBE controversy. Environmental Forensics 2, 29-59.
15. Gray, L. E., Jr. 1998: Xenoendocrine disrupters: laboratory studies on male reproductive effects1. Toxicology Letters 102-103, 331-335.
16. Lee, L. C., Quintana, J. J. E. and de Peyster, A. 1998: Comet assay evaluation of the effects of methyl t-butyl ether (MTBE) on rat hepatocytes. Toxicologist 42, 187-187.
17. Mangelsdorf, I., Buschmann, J. and Orthen, B. 2003: Some aspects relating to the evaluation of the effects of chemicals on male fertility. Regulatory Toxicology and Pharmacology 37, 356-369.
18. Mieusset, R. and Bujan, L. 1995: Testicular heating and its possible contributions to male infertility: a review. International Journal of Andrology 18, 169-184.
19. Moser, G. J., Wong, B. A., Wolf, D. C. et al. 1996: Comparative short-term effects of methyl tertiary butyl ether and unleaded gasoline vapor in female B6C3F1 mice. Fundamental and Applied Toxicology 31, 173-183.
20. Mruk, D. D. and Cheng, C. Y. 2000: In vitro regulation of extracellular superoxide dismutase in Sertoli cells. Life Sciences 67, 133-145.
21. Nihlén, A., Wålinder, R., Löf, A. and Johanson, G. 1998: Experimental exposure to methyl tertiary-butyl ether. Toxicology and Applied Pharmacology 148, 281-287.
22. Poet, T. S., Valentine, J. L., Borghoff, S. J., 1997: Pharmacokinetics of tertiory butyl alcohol in male and female Fischer 344 rats. Toxicology Letters 92, 179-186.
23. Prescott-Mathews, J. S., Wolf, D. C., Wong, B. A. and Borghoff, S. J. 1997: Methyl tert-butyl ether causes a2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats. Toxicology and Applied Pharmacology 143, 301-314.
24. Prescott-Mathews, J. S., Poet, T. S. and Borghoff, S. J. 1999: Evaluation of the in vivo interaction of methyl tert-butyl ether with a2m-globulin in male F-344 rats. Toxicology and Applied Pharmacology 157, 60-67.
25. Raychoudhury, S. S., Blake, C. A. and Millette, C. F. 1999: Toxic effects of octylphenol on cultured rat spermatogenic cells and Sertoli cells. Toxicology and Applied Pharmacology 157, 192-202.
26. Shioda, T. and Wakabayashi, M. 2000: Effect of certain chemicals on the reproduction of medaka (Oryzias latipes). Chemosphere 40, 239-243.
27. Slater, T. F., Sawyer, B. and Struli, U. 1963: Studies on succinate-tetrazolium reductase systems III, points of coupling of four different tetrazolium salts. Biochimica et Biophysica Acta 77, 383-393.
28. Swenberg, J. and Lehman-McKeeman, L. D. 1999: a2-Urinary globulin-associated nephropathy as a mechanism of renal tubule cell carcinogenesis in male rats. In Capen, C. C., Dybing, E., Rice, J. M. and Wilbourn, J. D., editors, Species differences: thyroid, kidney and urinary bladder carcinogenesis. IARC Scientific Publication No. 147, 95-118.
29. Uhler, A. D., Stout, S. A., Uhler, R. M. et al. 2001: Accurate chemical analysis of MTBE in environmental media. Environmental Forensics 2, 17-19.
30. USEPA (US Environmental Protection Agency). 1998: Oxygenates in water: critical information and research needs. Office of Research and Development, US Environmental Protection Agency, EPA/600/R-98/048.
31. Vance, D. B. 1998: MTBE: character in question. Environmental Technology 8, 1-12.
32. Veeramachaneni, D. N. R. 2000: Deteriorating trends in male reproduction: idiopathic or environmental? Animal Reproduction Science 60 -61, 121-130.
33. Williams, T. M., Cattley, R. C. and Borghoff, S. 2000: Alterations in endocrine responses on male Sprague-Dawley rats following oral administration of methyl tert-butyl ether. Toxicological Sciences 54, 168-176.
34. Williams-Hill, D., Spears, C. P., Prakash, S. et al. 1999: Mutagenicity studies of methyl-tert-butyl ether using the Ames tester strain TA102. Mutation Research 446, 15-21.
35. Zhou, W., Yuan, D., Huang, G. et al. 2000: Mutagenicity of methyl tertiary butyl ether. Journal of Environmental Pathology, Toxicology and Oncology 19, 35-39.