Synthesis and antioxidant evaluation of novel silybin analogues

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 4, 2006, Pages 399-404

  Yang, Leixiang ^a   Gong, Jingxu ^a   Wang, Feng ^a   Zhang, Yongmin ^b   Wang, Yanguang ^c   Hao, Xiaojiang ^d   Wu, Xiumei ^e   Bai, Hua ^e   Stöckigt, Joachim ^f   Zhao, Yu ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e Zhejiang Hisun Naturelite Pharmaceutical R and D Co Ltd   (China)

^f JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Antioxidant; DPPH; Free radical scavenging; Silybin analogues; Superoxide anion

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2 [2,3 DIHYDRO 3 (4 HYDROXY 3,5 PHENYL) 2 (HYDROXYMETHYL) 1,4 BENZODIOXIN 6 YL] 2,3 DIHYDRO 3,5,7 4H 1 BENZOPYRAN 4 ONE; ANTIOXIDANT; FREE RADICAL; QUERCETIN; SCAVENGER; SILIBININ DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCAVENGING SYSTEM; THIN LAYER CHROMATOGRAPHY;

ANIONS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; HYDRAZINES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PICRATES; QUERCETIN; SILYMARIN; SPECTROPHOTOMETRY; SUPEROXIDES;

EID: 33748511675     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360600682152     Document Type: Article

References (16)

1. Gilgun-Sherki, Y and Rosenbaum, Z and Melamed, E and Offen, D. (2002) Pharmacol Rev, 54, pp. 271-284.
2. Bennett, JP. (1999) J Neurol Sci, 170, pp. 75-76.
3. Gibson, GE and Huang, HM. (2005) Neurobiol Aging, 26, pp. 575-578.
4. Lefer, DJ and Granger, DN. (2000) Am J Med, 109, pp. 315-323.
5. Sukkar, SG and Rossi, E. (2004) Autoimmun Rev, 3, pp. 199-206.
6. Toyokuni, S and Okamoto, K and Yodoi, J and Hiai, H. (1995) FEBS Lett, 358, pp. 1-3.
7. Stehbens, WE. (2004) Exp Mol Pathol, 77, pp. 121-132.
8. Dvorak, Z and Kosina, P and Walterova, D and Simanek, V and Bachleda, P and Ulrichova, J. (2003) Toxicol Lett, 137, pp. 201-212.
9. Kosina, P and Křen, V and Gebhardt, R and Grambal, F and Ulrichová, J and Walterová, D. (2002) Phytother Res, 16, pp. S33-S39.
10. Varga, Z and Czompa, A and Kakuk, G and Antus, S. (2001) Phytother Res, 15, pp. 608-612.
11. Gažák, R and Svobodová, A and Psotová, J and Sedmera, P and Přikrylová, V and Walterová, D and Křen, V. (2004) Bioorg Med Chem, 12, pp. 5677-5687.
12. Stermitz, FR and Tawara-Matsuda, J and Lorenz, P and Mueller, P and Zenewicz, L and Kim, L. (2000) J Nat Prod, 63, pp. 1146-1149.
13. Merlini, L and Zanarotti, A and Pelter, A and Rochefort, MP and Hänsel, R. (1980) J Chem Soc, Perkin Trans, 1, pp. 775-778.
14. Robak, J and Gryglewski, RJ. (1988) Biochem Pharmacol, 37, pp. 837-841.
15. Tapia, A and Rodriguez, J and Theoduloz, C and Lopez, S and Feresin, GE and Schmeda-Hirschmann, G. (2004) J Ethnopharmacol, 95, pp. 155-161.
16. Fujisawa, S and Atsumi, T and Kadoma, Y and Sakagami, H. (2002) Toxicology, 177, pp. 39-54.