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Volumn 55, Issue 8, 2006, Pages 835-845

Sepsis. Update on pathophysiology, diagnostics and therapy;Sepsis. Aktuelle aspekte zu pathophysiologie, diagnostik und therapie

Author keywords

German Sepsis Society; Guidelines; Host response; Infection; Surviving Sepsis Campaign

Indexed keywords

ACTIVATED PROTEIN C; COMPLEMENT; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

EID: 33748506065     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00101-006-1034-3     Document Type: Review
Times cited : (14)

References (71)
  • 1
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
    • Abraham E, Reinhart K, Opal S et al.; OPTIMIST Trial Study Group (2003) Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 290(2): 238-247
    • (2003) JAMA , vol.290 , Issue.2 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3
  • 2
    • 0026874127 scopus 로고
    • Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • ACCP/SCCM Consensus Conference Committee (1992) Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20(6): 864-874
    • (1992) Crit Care Med , vol.20 , Issue.6 , pp. 864-874
  • 3
    • 0036213966 scopus 로고    scopus 로고
    • Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
    • Alberti C, Brun-Buisson C, Burchardi H et al.(2002) Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med 28 (2): 108-121
    • (2002) Intensive Care Med , vol.28 , Issue.2 , pp. 108-121
    • Alberti, C.1    Brun-Buisson, C.2    Burchardi, H.3
  • 4
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    • Annane D, Sebille V, Charpentier C et al. (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288(7): 862-871
    • (2002) JAMA , vol.288 , Issue.7 , pp. 862-871
    • Annane, D.1    Sebille, V.2    Charpentier, C.3
  • 5
    • 0030324314 scopus 로고    scopus 로고
    • Involvement of bacteria/endotoxin translocation in the development of multiple organ failure
    • Bahrami S, Redl H, Yao YM, Schlag G (1996) Involvement of bacteria/endotoxin translocation in the development of multiple organ failure. Curr Top Microbiol Immunol 216: 239-258
    • (1996) Curr Top Microbiol Immunol , vol.216 , pp. 239-258
    • Bahrami, S.1    Redl, H.2    Yao, Y.M.3    Schlag, G.4
  • 6
    • 0141920370 scopus 로고    scopus 로고
    • Bench-to-bedside review: Microvascular dysfunction in sepsis-hemodynamics, oxygen transport, and nitric oxide
    • Bateman RM, Sharpe MD, Ellis CG (2003) Bench-to-bedside review: microvascular dysfunction in sepsis-hemodynamics, oxygen transport, and nitric oxide. Crit Care 7(5): 359-373
    • (2003) Crit Care , vol.7 , Issue.5 , pp. 359-373
    • Bateman, R.M.1    Sharpe, M.D.2    Ellis, C.G.3
  • 7
    • 0025065285 scopus 로고
    • Predicting bacteremia in hospitalized patients. A prospectively validated model
    • Bates DW, Cook EF, Goldman L, Lee TH (1990) Predicting bacteremia in hospitalized patients. A prospectively validated model. Ann Intern Med 113(7): 495-500
    • (1990) Ann Intern Med , vol.113 , Issue.7 , pp. 495-500
    • Bates, D.W.1    Cook, E.F.2    Goldman, L.3    Lee, T.H.4
  • 8
    • 0030699238 scopus 로고    scopus 로고
    • Predicting bacteremia in patients with sepsis syndrome
    • Academic Medical Center Consortium Sepsis Project Working Group
    • Bates DW, Sands K, Miller E et al. (1997) Predicting bacteremia in patients with sepsis syndrome. Academic Medical Center Consortium Sepsis Project Working Group. J Infect Dis 176(6): 1538-1551
    • (1997) J Infect Dis , vol.176 , Issue.6 , pp. 1538-1551
    • Bates, D.W.1    Sands, K.2    Miller, E.3
  • 9
    • 3042793210 scopus 로고    scopus 로고
    • Akutes Leberversagen. Aktuelle Aspekte zur Diagnostik und Therapie
    • Bauer M, Paxian M, Kortgen A (2004) Akutes Leberversagen. Aktuelle Aspekte zur Diagnostik und Therapie. Anaesthesist 53: 511-530
    • (2004) Anaesthesist , vol.53 , pp. 511-530
    • Bauer, M.1    Paxian, M.2    Kortgen, A.3
  • 10
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in the critically ill patients
    • Berghe G van den, Wouters P, Weekers F et al. (2001) Intensive insulin therapy in the critically ill patients. N Engl J Med 345(19): 1359-1367
    • (2001) N Engl J Med , vol.345 , Issue.19 , pp. 1359-1367
    • Van Den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 11
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF et al. (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344(10): 699-709
    • (2001) N Engl J Med , vol.344 , Issue.10 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 12
    • 0037309925 scopus 로고    scopus 로고
    • Pathogenesis of sepsis: New concepts and implications for future treatment
    • Bochud PY, Calandra T (2003) Pathogenesis of sepsis: new concepts and implications for future treatment. BMJ 326(7383): 262-266
    • (2003) BMJ , vol.326 , Issue.7383 , pp. 262-266
    • Bochud, P.Y.1    Calandra, T.2
  • 13
    • 33748498606 scopus 로고    scopus 로고
    • Thrombotic microangiopathy (TMA) in patients with SIRS following open heart surgery - Role of VWF cleaving protease ADAMTS13
    • Bockmeyer CL, Claus RA, Lösche W et al. (2005) Thrombotic microangiopathy (TMA) in patients with SIRS following open heart surgery - role of VWF cleaving protease ADAMTS13. Infection 33 [Suppl 1]: 16
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 16
    • Bockmeyer, C.L.1    Claus, R.A.2    Lösche, W.3
  • 14
    • 0029903114 scopus 로고    scopus 로고
    • Sir Isaac Newton, sepsis, SIRS, and CARS
    • Bone RC (1996) Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med 24: 1125-1128
    • (1996) Crit Care Med , vol.24 , pp. 1125-1128
    • Bone, R.C.1
  • 15
    • 0141566202 scopus 로고    scopus 로고
    • The cost of sepsis syndromes in the intensive care unit and influence of hospital acquired sepsis
    • Brun-Boisson C, Roudot-Thoraval F, Girou E et al. (2003) The cost of sepsis syndromes in the intensive care unit and influence of hospital acquired sepsis. Intensive Care Med 29: 1464-1471
    • (2003) Intensive Care Med , vol.29 , pp. 1464-1471
    • Brun-Boisson, C.1    Roudot-Thoraval, F.2    Girou, E.3
  • 16
    • 0032734656 scopus 로고    scopus 로고
    • Discrimination of infectious causes of early acute respiratory distress syndrome by procalcitonin
    • Brunkhorst FM, Eberhard OK, Brunkhorst R (1999) Discrimination of infectious causes of early acute respiratory distress syndrome by procalcitonin. Crit Care Med 27(10): 2172-2176
    • (1999) Crit Care Med , vol.27 , Issue.10 , pp. 2172-2176
    • Brunkhorst, F.M.1    Eberhard, O.K.2    Brunkhorst, R.3
  • 17
    • 0034111524 scopus 로고    scopus 로고
    • Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock
    • Brunkhorst FM, Wegscheider K, Forycki ZF, Brunkhorst R (2000) Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock. Intensive Care Med 26 [Suppl 2]: S148-S152
    • (2000) Intensive Care Med , vol.26 , Issue.2 SUPPL.
    • Brunkhorst, F.M.1    Wegscheider, K.2    Forycki, Z.F.3    Brunkhorst, R.4
  • 19
    • 19444378571 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis and septic shock in Germany - Results from the German Prevalence Study
    • Brunkhorst FM, Engel C, Bone H-G et al. and the German Competence Network Sepsis (SepNet) (2005) Epidemiology of severe sepsis and septic shock in Germany - Results from the German Prevalence Study. Crit Care 9 [Suppl 1]: 83
    • (2005) Crit Care , vol.9 , Issue.1 SUPPL. , pp. 83
    • Brunkhorst, F.M.1    Engel, C.2    Bone, H.-G.3
  • 20
    • 30344454539 scopus 로고    scopus 로고
    • Treatment of severe sepsis and septic shock in Germany: The gap between perception and practice - Result from the German Prevalence Study
    • Brunkhorst FM, Engel C, Jaschinsky U et al. and the German Competence Network Sepsis (SepNet) (2005) Treatment of severe sepsis and septic shock in Germany: the gap between perception and practice - result from the German Prevalence Study. Infection 33 [Suppl 1]: 49
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 49
    • Brunkhorst, F.M.1    Engel, C.2    Jaschinsky, U.3
  • 21
    • 33748481494 scopus 로고    scopus 로고
    • Prevalence of Infection in German intensive care units - Results from the German Prevalence Study
    • Brunkhorst FM, Engel C, Welte T, Bloos F et al. and the German Competence Network Sepsis (SepNet) (2005) Prevalence of Infection in German intensive care units - Results from the German Prevalence Study. Infection 33 [Suppl 1]: 47
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 47
    • Brunkhorst, F.M.1    Engel, C.2    Welte, T.3    Bloos, F.4
  • 22
    • 30344454539 scopus 로고    scopus 로고
    • Intensive insulin therapy in patient with severe sepsis and septic shock is associated with an increased rate of hypoglycemia - Results from randomized multicenter study (VISEP)
    • Brunkhorst FM, Kuhnt E, Engel C et al. and the German Competence Network Sepsis (SepNet) (2005) Intensive insulin therapy in patient with severe sepsis and septic shock is associated with an increased rate of hypoglycemia - results from randomized multicenter study (VISEP). Infection 33 [Suppl 1]: 19
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 19
    • Brunkhorst, F.M.1    Kuhnt, E.2    Engel, C.3
  • 23
    • 2442544541 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of procalcitonin in patients with septic shock
    • Clec'h C, Ferriere F, Karoubi P et al. (2004) Diagnostic and prognostic value of procalcitonin in patients with septic shock. Crit Care Med 32(5): 1166-1169
    • (2004) Crit Care Med , vol.32 , Issue.5 , pp. 1166-1169
    • Clec'h, C.1    Ferriere, F.2    Karoubi, P.3
  • 24
    • 0034835936 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition as therapy for sepsis: A decade of promise
    • Cobb JP (2001) Nitric oxide synthase inhibition as therapy for sepsis: a decade of promise. Surg Infect (Larchmt) 2(2): 93-100; discussion 100-101
    • (2001) Surg Infect (Larchmt) , vol.2 , Issue.2 , pp. 93-100
    • Cobb, J.P.1
  • 25
    • 0003684486 scopus 로고    scopus 로고
    • Molecular biology of multiple organ dysfunction syndrome: Injury, adaptation, and apoptosis
    • Cobb JP, Buchman TG, Karl IE, Hotchkiss RS (2000) Molecular biology of multiple organ dysfunction syndrome: injury, adaptation, and apoptosis. Surg Infect (Larchmt) 1(3): 207-215
    • (2000) Surg Infect (Larchmt) , vol.1 , Issue.3 , pp. 207-215
    • Cobb, J.P.1    Buchman, T.G.2    Karl, I.E.3    Hotchkiss, R.S.4
  • 26
    • 0034922431 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor activity in severe sepsis
    • Creasey AA, Reinhart K (2001) Tissue factor pathway inhibitor activity in severe sepsis. Crit Care Med 29 [Suppl 7]: S126-129
    • (2001) Crit Care Med , vol.29 , Issue.7 SUPPL.
    • Creasey, A.A.1    Reinhart, K.2
  • 27
    • 0031783167 scopus 로고    scopus 로고
    • Bacteraemia in the adult intensive care unit of a teaching hospital in Nottingham, UK, 1985-1996
    • Crowe M, Ispahani P, Humphreys H et al. (1998) Bacteraemia in the adult intensive care unit of a teaching hospital in Nottingham, UK, 1985-1996. Eur J Clin Microbiol Infect Dis 17(6): 377-384
    • (1998) Eur J Clin Microbiol Infect Dis , vol.17 , Issue.6 , pp. 377-384
    • Crowe, M.1    Ispahani, P.2    Humphreys, H.3
  • 28
    • 11144354132 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    • Dellinger RP, Carlet JM, Masur H et al. (2004) Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 30: 536-555
    • (2004) Intensive Care Med , vol.30 , pp. 536-555
    • Dellinger, R.P.1    Carlet, J.M.2    Masur, H.3
  • 29
    • 1842788553 scopus 로고    scopus 로고
    • Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score
    • Dempfle CE, Wurst M, Smolinski M et al. (2004) Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score. Thromb Haemost 91: 812-818
    • (2004) Thromb Haemost , vol.91 , pp. 812-818
    • Dempfle, C.E.1    Wurst, M.2    Smolinski, M.3
  • 30
    • 33748490013 scopus 로고    scopus 로고
    • The SepNet Sepsis Prevalence Study: Concept, design, and technical aspects of a nationwide cross-sectional survey on the epidemiology of sepsis in German ICUs
    • Engel C, Brunkhorst FM, Reinhart K, Löffler M and the German Competence Network Sepsis (SepNet) (2005) The SepNet Sepsis Prevalence Study: concept, design, and technical aspects of a nationwide cross-sectional survey on the epidemiology of sepsis in German ICUs. Infection 33 [Suppl 1]: 48
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 48
    • Engel, C.1    Brunkhorst, F.M.2    Reinhart, K.3    Löffler, M.4
  • 31
    • 33748509264 scopus 로고    scopus 로고
    • Incidence of sepsis in German ICUs - Results from the German Prevalence Study
    • Engel C, Brunkhorst FM, Reinhart K, Löffler M and the German Competence Network Sepsis (SepNet) (2005) Incidence of sepsis in German ICUs - Results from the German Prevalence Study. Infection 33 [Suppl 1]: 50
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 50
    • Engel, C.1    Brunkhorst, F.M.2    Reinhart, K.3    Löffler, M.4
  • 32
    • 1942439753 scopus 로고    scopus 로고
    • Crosstalk between inflammation and thrombosis
    • Esmon CT (2004) Crosstalk between inflammation and thrombosis. Maturitas 47(4): 305-314
    • (2004) Maturitas , vol.47 , Issue.4 , pp. 305-314
    • Esmon, C.T.1
  • 34
    • 0035421655 scopus 로고    scopus 로고
    • Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis
    • Harbarth S, Holeckova K, Froidevaux C et al.; Geneva Sepsis Network (2001) Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164(3): 396-402
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.3 , pp. 396-402
    • Harbarth, S.1    Holeckova, K.2    Froidevaux, C.3
  • 35
    • 0345107246 scopus 로고    scopus 로고
    • High-dose vasopressin is not superior to norepinephrine in septic shock
    • Klinzing S, Simon M, Reinhart K et al. (2003) High-dose vasopressin is not superior to norepinephrine in septic shock. Crit Care Med 31(11): 2646-2650
    • (2003) Crit Care Med , vol.31 , Issue.11 , pp. 2646-2650
    • Klinzing, S.1    Simon, M.2    Reinhart, K.3
  • 36
    • 33645076841 scopus 로고    scopus 로고
    • Implementation of an evidence-based "standard operating procedure" and outcome in septic shock
    • Kortgen A, Niederprüm P, Bauer M (2006) Implementation of an evidence-based "standard operating procedure" and outcome in septic shock. Crit Care Med 34: 943-949
    • (2006) Crit Care Med , vol.34 , pp. 943-949
    • Kortgen, A.1    Niederprüm, P.2    Bauer, M.3
  • 37
    • 0037108543 scopus 로고    scopus 로고
    • Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: A prospective, stratified, randomized, double-blind, placebo-controlled clinical trial
    • Krueger WA, Lenhart FP, Neeser G et al. (2002) Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med 166(8): 1029-1037
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.8 , pp. 1029-1037
    • Krueger, W.A.1    Lenhart, F.P.2    Neeser, G.3
  • 38
    • 0026095163 scopus 로고
    • Bacteremia in febrile patients. A clinical model for diagnosis
    • Leibovici L, Greenshtain S, Cohen O et al. (1991) Bacteremia in febrile patients. A clinical model for diagnosis. Arch Intern Med 151(9): 1801-1806
    • (1991) Arch Intern Med , vol.151 , Issue.9 , pp. 1801-1806
    • Leibovici, L.1    Greenshtain, S.2    Cohen, O.3
  • 39
    • 1242337462 scopus 로고    scopus 로고
    • New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology
    • Levi M, Jonge E de, Poll T van der (2004) New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology. Ann Med 36(1): 41-49
    • (2004) Ann Med , vol.36 , Issue.1 , pp. 41-49
    • Levi, M.1    De Jonge, E.2    Van Der Poll, T.3
  • 40
    • 0035807348 scopus 로고    scopus 로고
    • Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
    • Levy GG, Nichols WC, Lian EC et al. (2001) Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 413: 488-494
    • (2001) Nature , vol.413 , pp. 488-494
    • Levy, G.G.1    Nichols, W.C.2    Lian, E.C.3
  • 41
    • 8444230449 scopus 로고    scopus 로고
    • Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome
    • Levy MM, Pronovost PJ, Dellinger RP et al. (2004) Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med 32 [Suppl]: S595-597
    • (2004) Crit Care Med , vol.32 , Issue.SUPPL.
    • Levy, M.M.1    Pronovost, P.J.2    Dellinger, R.P.3
  • 42
    • 10744222717 scopus 로고    scopus 로고
    • Epidemiology of candidemia in Swiss tertiary care hospitals: Secular trends 1991-2000
    • Fungal Infection Network of Switzerland
    • Marchetti O, Bille J, Fluckiger U et al. (2004) Fungal Infection Network of Switzerland. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends 1991-2000. Clin Infect Dis 38: 311-320
    • (2004) Clin Infect Dis , vol.38 , pp. 311-320
    • Marchetti, O.1    Bille, J.2    Fluckiger, U.3
  • 43
    • 0038482456 scopus 로고    scopus 로고
    • Such stuff as dreams are made on: Mediator-directed therapy in sepsis
    • Marshall JC (2003) Such stuff as dreams are made on: mediator-directed therapy in sepsis. Nat Rev Drug Discov 2(5): 391-405
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.5 , pp. 391-405
    • Marshall, J.C.1
  • 44
    • 0027169430 scopus 로고
    • The gastrointestinal tract. The "undrained abscess" of multiple organ failure
    • Marshall JC, Christou NV, Meakins JL (1993) The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg 218(2): 111-119
    • (1993) Ann Surg , vol.218 , Issue.2 , pp. 111-119
    • Marshall, J.C.1    Christou, N.V.2    Meakins, J.L.3
  • 45
    • 0028784689 scopus 로고
    • Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome
    • Marshall JC, Cook DJ, Christou NV et al. (1995) Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23(10): 1638-1652
    • (1995) Crit Care Med , vol.23 , Issue.10 , pp. 1638-1652
    • Marshall, J.C.1    Cook, D.J.2    Christou, N.V.3
  • 46
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348(16): 1546-1554
    • (2003) N Engl J Med , vol.348 , Issue.16 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 47
    • 0031822857 scopus 로고    scopus 로고
    • Postoperative plasma concentrations of procalcitonin after different types of surgery
    • Meisner M, Tschaikowsky K, Hutzler A et al. (1998) Postoperative plasma concentrations of procalcitonin after different types of surgery. Intensive Care Med 24(7): 680-684
    • (1998) Intensive Care Med , vol.24 , Issue.7 , pp. 680-684
    • Meisner, M.1    Tschaikowsky, K.2    Hutzler, A.3
  • 48
    • 0037158606 scopus 로고    scopus 로고
    • Thrombotic microangiopathies
    • Moake JL (2002) Thrombotic microangiopathies. N Engl J Med 347: 589-600
    • (2002) N Engl J Med , vol.347 , pp. 589-600
    • Moake, J.L.1
  • 49
    • 0036390209 scopus 로고    scopus 로고
    • Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use
    • Moerer O, Schmid A, Hofmann M et al. (2002) Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use. Intensive Care Med 28(10): 1440-1446
    • (2002) Intensive Care Med , vol.28 , Issue.10 , pp. 1440-1446
    • Moerer, O.1    Schmid, A.2    Hofmann, M.3
  • 50
    • 0034060554 scopus 로고    scopus 로고
    • Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit
    • Müller B, Becker KL, Schächinger H et al. (2000) Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 28(4): 977-983
    • (2000) Crit Care Med , vol.28 , Issue.4 , pp. 977-983
    • Müller, B.1    Becker, K.L.2    Schächinger, H.3
  • 51
    • 0032741946 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation: Clinical spectrum and established as well as new diagnostic approaches
    • Müller-Berghaus G, Cate H ten, Levi M (1999) Disseminated intravascular coagulation: clinical spectrum and established as well as new diagnostic approaches. Thromb Haemost 82(2): 706-712
    • (1999) Thromb Haemost , vol.82 , Issue.2 , pp. 706-712
    • Müller-Berghaus, G.1    Ten Cate, H.2    Levi, M.3
  • 52
    • 0141576826 scopus 로고    scopus 로고
    • The influence of infection on hospital mortality for patients requiring >48 h of intensive care
    • Osmon S, Warren D, Seiler SM et al. (2003) The influence of infection on hospital mortality for patients requiring >48 h of intensive care. Chest 124:1021-1029
    • (2003) Chest , vol.124 , pp. 1021-1029
    • Osmon, S.1    Warren, D.2    Seiler, S.M.3
  • 53
    • 0029015753 scopus 로고
    • The acute-phase response
    • Pannen BH, Robotham JL (1995) The acute-phase response. New Horiz 3(2): 183-197
    • (1995) New Horiz , vol.3 , Issue.2 , pp. 183-197
    • Pannen, B.H.1    Robotham, J.L.2
  • 54
    • 0036187359 scopus 로고    scopus 로고
    • Beneficial effects of short-term vasopressin infusion during severe septic shock
    • Patel BM, Chittock DR, Russell JA, Walley KR (2002) Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology 96(3): 576-582
    • (2002) Anesthesiology , vol.96 , Issue.3 , pp. 576-582
    • Patel, B.M.1    Chittock, D.R.2    Russell, J.A.3    Walley, K.R.4
  • 55
    • 0037711138 scopus 로고    scopus 로고
    • Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation
    • Paxian M, Bauer I, Rensing H et al. (2003) Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation. FASEB J 17(9): 993-1002
    • (2003) FASEB J , vol.17 , Issue.9 , pp. 993-1002
    • Paxian, M.1    Bauer, I.2    Rensing, H.3
  • 56
    • 0036905885 scopus 로고    scopus 로고
    • The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction
    • Peres Bota D, Melot C, Lopes Ferreira F et al. (2002) The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction. Intensive Care Med 28(11): 1619-1624
    • (2002) Intensive Care Med , vol.28 , Issue.11 , pp. 1619-1624
    • Peres Bota, D.1    Melot, C.2    Lopes Ferreira, F.3
  • 57
    • 0036255482 scopus 로고    scopus 로고
    • Markers of endothelial damage in organ dysfunction and sepsis
    • Reinhart K, Bayer O, Brunkhorst F, Meisner M (2002) Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med 30 [5 Suppl]: S302-312
    • (2002) Crit Care Med , vol.30 , Issue.5 SUPPL.
    • Reinhart, K.1    Bayer, O.2    Brunkhorst, F.3    Meisner, M.4
  • 58
    • 0036894517 scopus 로고    scopus 로고
    • Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver
    • Rensing H, Bauer I, Zhang JX et al. (2002) Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver. Hepatology 36(6): 1453-1465
    • (2002) Hepatology , vol.36 , Issue.6 , pp. 1453-1465
    • Rensing, H.1    Bauer, I.2    Zhang, J.X.3
  • 60
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • Rivers E, Nguyen B, Havstad S et al.; Early Goal-Directed Therapy Collaborative Group (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19): 1368-1377
    • (2001) N Engl J Med , vol.345 , Issue.19 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3
  • 61
    • 0022442847 scopus 로고
    • Is intensive care worth it? An assessment of input and outcome for the critically ill
    • Sage WM, Rosenthal MH, Silverman JF (1986) Is intensive care worth it? An assessment of input and outcome for the critically ill. Crit Care Med 14(9): 777-782
    • (1986) Crit Care Med , vol.14 , Issue.9 , pp. 777-782
    • Sage, W.M.1    Rosenthal, M.H.2    Silverman, J.F.3
  • 62
    • 0036433328 scopus 로고    scopus 로고
    • Prognostic value of the indocyanine green plasma disappearance rate in critically ill patients
    • Sakka SG, Reinhart K, Meier-Hellmann A (2002) Prognostic value of the indocyanine green plasma disappearance rate in critically ill patients. Chest 122(5): 1715-1720
    • (2002) Chest , vol.122 , Issue.5 , pp. 1715-1720
    • Sakka, S.G.1    Reinhart, K.2    Meier-Hellmann, A.3
  • 63
    • 33645094435 scopus 로고    scopus 로고
    • How is mechanical ventilation employed in septic patients in Germany? - Results from the SepNet Prevalence Study
    • Schaedler D, Schmitz G, Frerichs I et al. and the German Competence Network Sepsis (SepNet) (2005) How is mechanical ventilation employed in septic patients in Germany? - Results from the SepNet Prevalence Study. Infection 33 [Suppl 1]: 46
    • (2005) Infection , vol.33 , Issue.1 SUPPL. , pp. 46
    • Schaedler, D.1    Schmitz, G.2    Frerichs, I.3
  • 64
    • 0023870774 scopus 로고
    • Genetic and environmental influences on premature death in adult adoptees
    • Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW (1988) Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 318(12): 727-732
    • (1988) N Engl J Med , vol.318 , Issue.12 , pp. 727-732
    • Sorensen, T.I.1    Nielsen, G.G.2    Andersen, P.K.3    Teasdale, T.W.4
  • 65
    • 0035143744 scopus 로고    scopus 로고
    • Effects of genomic polymorphisms on the course of sepsis: Is there a concept for gene therapy?
    • Stüber A (2001) Effects of genomic polymorphisms on the course of sepsis: is there a concept for gene therapy? Am Soc Nephrol 12 [Suppl 17]: S60-64
    • (2001) Am Soc Nephrol , vol.12 , Issue.17 SUPPL.
    • Stüber, A.1
  • 66
    • 0029912586 scopus 로고    scopus 로고
    • Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon
    • Taylor FB Jr (1996) Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon. Haemostasis 26 [Suppl 1]: 83-91
    • (1996) Haemostasis , vol.26 , Issue.1 SUPPL. , pp. 83-91
    • Taylor Jr., F.B.1
  • 67
    • 0029148091 scopus 로고
    • The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study
    • EPIC International Advisory Committee
    • Vincent JL, Bihari DJ, Suter PM et al. (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study. EPIC International Advisory Committee. JAMA 274(8): 639-644
    • (1995) JAMA , vol.274 , Issue.8 , pp. 639-644
    • Vincent, J.L.1    Bihari, D.J.2    Suter, P.M.3
  • 68
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure
    • On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine
    • Vincent JL, Moreno R, Takala J et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22(7): 707-710
    • (1996) Intensive Care Med , vol.22 , Issue.7 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3
  • 69
    • 0036972302 scopus 로고    scopus 로고
    • Reducing mortality in sepsis: New directions
    • Vincent JL, Abraham E, Annane D et al. (2002) Reducing mortality in sepsis: new directions. Crit Care 6 [Suppl 3]: S1-18
    • (2002) Crit Care , vol.6 , Issue.3 SUPPL.
    • Vincent, J.L.1    Abraham, E.2    Annane, D.3
  • 70
    • 2542451293 scopus 로고    scopus 로고
    • Comparison of mechanisms after post-hoc analyses of the drotrecogin alfa (activated) and antithrombin III trials in severe sepsis
    • Wiedermann CJ, Kaneider NC (2004) Comparison of mechanisms after post-hoc analyses of the drotrecogin alfa (activated) and antithrombin III trials in severe sepsis. Ann Med 36(3): 194-203
    • (2004) Ann Med , vol.36 , Issue.3 , pp. 194-203
    • Wiedermann, C.J.1    Kaneider, N.C.2
  • 71
    • 0030746482 scopus 로고    scopus 로고
    • Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
    • Zeni F, Freeman B, Natanson C (1997) Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 25(7): 1095-1100
    • (1997) Crit Care Med , vol.25 , Issue.7 , pp. 1095-1100
    • Zeni, F.1    Freeman, B.2    Natanson, C.3


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