HDL- associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development

Pathophysiology of Haemostasis and Thrombosis

Volumn 35, Issue 1-2, 2006, Pages

  Aviram, Michael ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Antioxidants Pomegranate; Macrophage Atherosclerosis; Oxidative stress; Paraoxonase; Red Wine

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ARYLDIALKYLPHOSPHATASE 1; ESTERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NUTRACEUTICAL;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL TRANSPORT; CONFERENCE PAPER; FOAM CELL; LIPID HYDROLYSIS; LIPID PEROXIDATION; MACROPHAGE; NUTRITIONAL ASSESSMENT; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK FACTOR;

EID: 33748502306     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093558     Document Type: Conference Paper

References (13)

1. Aviram M. Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases. Free Radic Res 33: S85-S97 (2000).
2. Aviram M and Rosenblat M. Paraoxonases 1, 2 and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development. Free Radic. Biol. Med. 37: 1304-1316 (2004).
3. Rosenblat M. and Aviram M. Nutritional, pharmacological and metabolic influences on paraoxonase, Curr. Opin. Lipidol. 16: 393-399 (2005).
4. Fuhrman B. and Aviram M. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Opin Lipidol 12: 41-48 (2001).
5. Aviram M., Dornfeld L., Rosenblat M., Volkova N., Kaplan M., Hayek T., Presser D. and Fuhrman B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in the atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 71: 1062-1076 (2000).
6. Fuhrman B., A. Lavy and M. Aviram. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am J Clin Nutr 61: 549-554 (1995).
7. Aviram M., Rosenbalt M., Gaitini D., Nitecki S., Hoffman A., Dornfeld L., Volkova N., Presser D., Attias J., Leiker H. and Hayek T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 23: 423-433 (2004).
8. Aviram M., Kaplan M., Rosenblat M. and Fuhrman B. Dietary antioxidants against LDL oxidation and atheroslceosis development: protective role for paraoxonase. In: Handbook of Experimental Pharmacology (HEP) : Arteriosclerosis; Influence of Diet and Drugs. Ed. A. von Eckardstein 170: 259-296 (2005).
9. Rozenberg O., Rosenblat M., Coleman R., Shih D.M. and Aviram M. Paraoxonase (PON 1) deficiency is associated with increased macrophage oxidative stress: studies in PON1 - knockout mice. Free Radic Biol Med 34:774-784 (2003).
10. Rozenberg O., Shih D. and Aviram M. Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON 1 transfected cells and in PON1 transgenic mice. Atherosclerosis 181:9-18 (2005).
11. Harel M., Aharoni A., Gaidukov L., Brumshtein B., Khersonsky O., Meged R., Dvir H., Ravelli R.B.G., McCarthy A., Toker L., Silman I., Sussman J. and Tawfik D.S. Structure and evolution of the serum paraoxoanse family of detoxifying and anti-atherosclerotic enzymes. Nature Struct. & Mole. Biol. 11: 412-419 (2004).
12. Rosenblat M, Gaidukov L, Khersonsky O, Vaya J, Oren R, Tawfik DS, Aviram M. The catalytic histidine dyad of HDL-associated serum paraoxonase 1 (PON1) is essential for PON1-mediated inhibition of LDL oxidation and for stimulation of macrophage cholesterol efflux. J Biol Chem. (2006, in press).
13. Rosenblat M., Karry R. and Aviram M. Paraoxonase 1 (PON 1) is more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: Relveance to diabetes. Atherosclerosis. 184: 255-265 (2006).