In vitro sensitivity of Leishmania donovani to organometallic derivatives of pentamidine

Parasitology Research

Volumn 83, Issue 5, 1997, Pages 515-517

  Mbongo, N ^a,b   Loiseau, P M ^b   Lawrence, F ^a   Bories, C ^b   Craciunescu, D G ^c   Robert Gero, M ^a  

^a INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANOMETALLIC COMPOUND; PENTAMIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; KINETOPLAST; LEISHMANIA DONOVANI; LEISHMANIASIS; PRIORITY JOURNAL; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPROTOZOAL AGENTS; LEISHMANIA DONOVANI; MACROPHAGES, PERITONEAL; MICE; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PENTAMIDINE;

EID: 0030971116     PISSN: 00443255     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050290     Document Type: Article

References (12)

1. Croft SL, Neal RA, Craciunescu DG, Certad-Fombona G (1992) The activity of platinum, iridium and rhodium drug complexes against Leishmania donovani. Trop Med Parasitol 43: 24-28
2. Dreyfuss G, Gayral P, Dubost G, Nicolas JA, Craciunescu DG (1988) Activité antiparasitaire du cis-Pt(II) pentamidine dans la trypanosomose expérimentale du mouton à Trypanosoma brucei brucei. Bull Soc Pathol Exot Filiales 81: 561-570
3. Dreyfuss G, Pénicaut B, Nicolas JA, Craciunescu DG, Loiseau PM (1993) Trypanocidal activity and platinum plasma kinetics of cis-Pt pentamidine iodide in Trypanosoma brucei sheep model. Trop Med Parasitol 44: 95-98
4. Dreyfuss G, Loiseau PM, Lachâtre G, Pénicaut B, Nicolas JA, Craciunescu DG (1995) Trypanosoma brucei brucei: antitrypanosomal evaluation of stilbamidinium hexachloroiridiate on the murine CNS model and iridium serum kinetics in infected sheep. Trop Med Parasitol 46: 41-44
5. Farrell NP, Williamson J, McLaren DJM (1984) Trypanocidal and antitumor activity of platinum metal and platinum-metal-drug dual function complexes. Biochem Pharmacol 33: 961-971
6. Gayral P, Loiseau PM, Craciunescu DG (1992) Complexes organométalliques d'iridium ayant une action antiparasitaire. French Patent 9200669. French Patent Office, Paris
7. Kinnamon KE, Steck EA, Rane DS (1979) Activity of antitumor drugs against African trypanosomes. Antimicrob Agents Chemother 15: 157-160
8. Loiseau PM, Craciunescu DG, Doadrio-Villarejo JC, Certad-Fombona G, Gayral P (1992) Pharmacomodulations on new organometallic complexes of Ir, Pt, Rh, Pd, Os: in vitro and in vivo trypanocidal study against Trypanosoma brucei brucei. Trop Med Parasitol 43: 110-114
9. Mesa-Valle CM, Craciunescu DG, Parrondo-Iglesias E, Osuna A (1989) In vitro action of platinum(II) and platinum(IV) complexes on Trypanosoma cruzi and Leishmania donovani. Arzneimittelforschung 39: 838-842
10. Mossman T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63
11. Neal RA, Croft SL (1984) An in vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani. J Antimicrob Chemother 14: 463-475
12. Sands M, Kron M, Brown RB (1985) Pentamidine: a review. Rev Infect Dis 7: 625-634