Living donor kidney transplant recipients and clinical trials: Participation profiles and impact on post-transplant care

American Journal of Transplantation

Volumn 6, Issue 10, 2006, Pages 2429-2435

  Brennan, T V ^a   Fuller, T F ^b   Vincenti, F ^a   Chan, S ^a   Chang, C K ^a   Bostrom, A ^a   Zlatunich, J K ^a   Tomlanovich, S J ^a   Feng, S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Clinical trial; Kidney transplant; Living donor; Outcomes

Indexed keywords

AZATHIOPRINE; B7 ANTIGEN; BASILIXIMAB; CD11 ANTIGEN; CD86 ANTIGEN; CORTICOSTEROID; CYCLOSPORIN A; DACLIZUMAB; FINGOLIMOD; GANCICLOVIR; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS; VALGANCICLOVIR; VISILIZUMAB;

ADULT; ALLOGRAFT; ARTICLE; BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE CLEARANCE; DEMOGRAPHY; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT REJECTION; HEALTH CENTER; HOSPITAL READMISSION; HUMAN; HUMAN TISSUE; INTENSIVE CARE; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MEDICAL CARE; MULTICENTER STUDY; PHASE 1 CLINICAL TRIAL; PHYSICIAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SURVIVAL RATE; TREATMENT OUTCOME; ULTRASOUND;

ADOLESCENT; ADULT; CHILD; CLINICAL TRIALS; CLINICAL TRIALS AS TOPIC; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; PATIENT COMPLIANCE; POSTOPERATIVE CARE; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 33748477305     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01504.x     Document Type: Article

References (18)

1. Corbie-Smith G, Thomas SB, Williams MV, Moody-Ayers S. Attitudes and beliefs of African Americans toward participation in medical research. J Gen Intern Med 1999; 14: 537-546.
2. Gifford AL, Cunningham WE, Heslin KC et al. Participation in research and access to experimental treatments by HIV-infected patients. N Engl J Med 2002; 346: 1373-1382.
3. Shavers VL, Lynch CF, Burmeister LF. Racial differences in factors that influence the willingness to participate in medical research studies. Ann Epidemiol 2002; 12: 248-256.
4. Karjalainen S, Palva I. Do treatment protocols improve end results? A study of survival of patients with multiple myeloma in Finland. Br Med J 1989; 299: 1069-1072.
5. Lennox EL, Stiller CA, Jones PH, Wilson LM. Nephroblastoma: Treatment during 1970-3 and the effect on survival of inclusion in the first MRC trial. Br Med J 1979; 2: 567-569.
6. Davis S, Wright PW, Schulman SF et al. Participants in prospective, randomized clinical trials for resected non-small cell lung cancer have improved survival compared with nonparticipants in such trials. Cancer 1985; 56: 1710-1718.
7. Marubini E, Mariani L, Salvadori B et al. Results of a breast-cancer-surgery trial compared with observational data from routine practice. Lancet 1996; 347: 1000-1003.
8. Roy P, Vaughan Hudson G, Vaughan Hudson B, Esteve J, Swerdlow AJ. Long-term survival in Hodgkin's disease patients. A comparison of relative survival in patients in trials and those recorded in population-based cancer registries. Eur J Cancer 2000; 36: 384-389.
9. Lantos JD. The "inclusion benefit" in clinical trials. J Pediatr 1999; 134: 130-131.
10. Peppercorn JM, Weeks JC, Cook EF, Joffe S. Comparison of outcomes in cancer patients treated within and outside clinical trials: Conceptual framework and structured review. Lancet 2004; 363: 263-270.
11. Reiser J, Warner JO. The value of participating in an asthma trial. Lancet 1985; 1: 206-207.
12. Tenenbaum A, Motro M, Fisman EZ et al. Does participation in a long-term clinical trial lead to survival gain for patients with coronary artery disease? Am J Med 2002; 112: 545-548.
13. Kasiske BL, Vazquez MA, Harmon WE et al. Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol 2000; 11(Suppl. 15): S1-S86.
14. Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: Race-, sex-, and age-based disparities. JAMA 2004; 291: 2720-2726.
15. Harris DJ, Douglas PS. Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute. N Engl J Med 2000; 343: 475-480.
16. Wilets I, O'Rourke M, Nassisi D. How patients and visitors to an urban emergency department view clinical research. Acad Emerg Med 2003; 10: 1081-1085.
17. Braunholtz DA, Edwards SJ, Lilford RJ. Are randomized clinical trials good for us (in the short term)? Evidence for a "trial effect". J Clin Epidemiol 2001; 54: 217-224.
18. Parsons H. What happened at Hawthorne? Science 1974; 183: 922-932.