Synthesis and biological activity of N-2,3-dihydroxypropyl-N-4-chlorobutyl nucleoside phosphoramidate prodrugs

Molecular Pharmaceutics

Volumn 3, Issue 4, 2006, Pages 451-456

  Wu, Weidong ^a,c   Borch, Richard F ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c LaserGen Inc   (United States)

Author keywords

Nucleoside; Phosphoramidate; Prodrug

Indexed keywords

FLOXURIDINE; N 2,3 DIHYDROXYPROPYL N 4 CHLOROBUTYL NUCLEOSIDE PHOSPHORAMIDATE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; THYMIDINE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL GROWTH; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGENOLYSIS; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLOXURIDINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORIC ACIDS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE;

EID: 33748474745     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp060006g     Document Type: Article

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