Autoimmune hepatitis triggered by statins

Journal of Clinical Gastroenterology

Volumn 40, Issue 8, 2006, Pages 757-761

  Alla, Vamsee ^a   Abraham, Joseph ^a   Siddiqui, Junaid ^a,c   Raina, Dimple ^a   Wu, George Y ^a   Chalasani, Naga P ^a,b   Bonkovsky, Herbert L ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Autoimmune hepatitis; Drug induced liver injury; HMG CoA reductase inhibitors; Immunosuppressive; Stains

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINUCLEAR ANTIBODY; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; AZATHIOPRINE; FLUINDOSTATIN; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; IRON; MYCOPHENOLIC ACID; PANTOPRAZOLE; PAROXETINE; PREDNISONE; SIMVASTATIN; SMOOTH MUSCLE ANTIBODY; ZOLPIDEM;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOIMMUNE DISEASE; CASE REPORT; CELL INFILTRATION; DOSE RESPONSE; FEMALE; HEPATITIS; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; HYPERGAMMAGLOBULINEMIA; LABORATORY TEST; LIVER BIOPSY; LIVER FIBROSIS; MALE; PLASMA CELL; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; TREATMENT WITHDRAWAL;

ANTILIPEMIC AGENTS; FEMALE; HEPATITIS, AUTOIMMUNE; HEPTANOIC ACIDS; HUMANS; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; MALE; MIDDLE AGED; PYRROLES; SIMVASTATIN;

EID: 33748452682     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-200609000-00018     Document Type: Review

References (17)

1. Krawitt E. Autoimmune Hepatitis. In: Schiff ER, Sorrell MF, Maddrey WC, eds. Philadelphia, PA: Lippincott, Williams & Wilkins; 2003:1001-1013.
2. Anonymous. Top 200 brand-name drugs by units in 2004 & Top 200 generic drugs by units in 2004. Drug Topics; 2005.
3. Chalasani N. Statins and hepatotoxicity: focus on patients with fatty liver. Hepatology. 2005;41:690-695.
4. Ahmad A, Fletcher MT, Roy TM. Simvastatin-induced lupus-like syndrome. Tenn Med. 2000;93:21-22.
5. Ahmad S. Lovastatin-induced lupus erythematosus. Arch Intern Med. 1991;151:1667-1668.
6. Bannwarth B, Miremont G, Papapietro PM. Lupuslike syndrome associated with simvastatin. Arch Intern Med. 1992;152:1093.
7. Hill C, Zeitz C, Kirkham B. Dermatomyositis with lung involvement in a patient treated with simvastatin. Aust N Z J Med. 1995;25:745-746.
8. Khattak FH, Morris IM, Branford WA. Simvastatin-associated dermatomyositis. Br J Rheumatol. 1994;33:199.
9. Khosla R, Butman AN, Hammer DF. Simvastatin-induced lupus erythematosus. South Med J. 1998;91:873-874.
10. Graziadei IW, Obermoser GE, Sepp NT, et al. Drug-induced lupus-like syndrome associated with severe autoimmune hepatitis. Lupus. 2003;12:409-412.
11. Pelli N, Setti M, Ceppa P, et al. Autoimmune hepatitis revealed by atorvastatin. Eur J Gastroenterol Hepatol. 2003;15:921-924.
12. Wolters LM, Van Buuren HR. Rosuvastatin-associated hepatitis with autoimmune features. Eur J Gastroenterol Hepatol. 2005;17:589-590.
13. Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929-938.
14. Kwak B, Mulhaupt F, Myit S, et al. Statins as a newly recognized type of immunomodulator. Nat Med. 2000;6:1399-1402.
15. Kwak B, Mulhaupt F, Veillard N, et al. The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. Swiss Med Wkly. 2001;131:41-46.
16. Sadeghi MM, Tiglio A, Sadigh K, et al. Inhibition of interferon-gamma- mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. Transplantation. 2001;71:1262-1268.
17. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22:696-699.