Assessment of epidermal subpopulations and proliferation in healthy skin, symptomless and lesional skin of spreading psoriasis

British Journal of Dermatology

Volumn 155, Issue 4, 2006, Pages 688-694

  Korver J E M ^a   Van Duijnhoven, M W F M ^a   Pasch, M C ^a   Van Erp, P E J ^a   Van De Kerkhof, P C M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Immunohistology; Keratin 15; Margin zone; Psoriasis; Transit amplifying cells

Indexed keywords

BETA1 INTEGRIN; KERATIN; KI 67 ANTIGEN;

ARTICLE; BASAL CELL; BASEMENT MEMBRANE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; EPIDERMIS CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SKIN BIOPSY;

ANTIGENS, CD29; CELL DIFFERENTIATION; CELL PROLIFERATION; EPIDERMIS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KERATINS; KI-67 ANTIGEN; PSORIASIS;

EID: 33748444010     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07403.x     Document Type: Article

References (31)

1. Sano S, Chan KS, Carbajal S et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 2005; 11:43-9.
2. Schon MP. Animal models of psoriasis - what can we learn from them? J Invest Dermatol 1999; 112:405-10.
3. Barker CL, McHale MT, Gillies AK et al. The development and characterization of an in vitro model of psoriasis. J Invest Dermatol 2004; 123:892-901.
4. Parent D, Bernard BA, Desbas C et al. Spreading of psoriatic plaques: alteration of epidermal differentiation precedes capillary leakiness and anomalies in vascular morphology. J Invest Dermatol 1990; 95:333-40.
5. de Mare S, de Jong EMGH, van Erp PEJ et al. Markers for proliferation and keratinization in the margin of the active psoriatic lesion. Br J Dermatol 1990; 122:469-75.
6. van de Kerkhof PCM, Rulo HF. The endothelium in the margin zone of spreading psoriatic plaques. J Invest Dermatol 1991; 96:529-30.
7. Vissers WH, Arndtz CH, Muys L et al. Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late. Br J Dermatol 2004; 150:852-9.
8. Thewes M, Stadler R, Korge B et al. Normal psoriatic epidermis expression of hyperproliferation-associated keratins. Arch Dermatol Res 1991; 283:465-71.
9. Gerritsen MJ, Elbers ME, de Jong EMGH et al. Recruitment of cycling epidermal cells and expression of filaggrin, involucrin and tenascin in the margin of the active psoriatic plaque, in the uninvolved skin of psoriatic patients and in the normal healthy skin. J Dermatol Sci 1997; 14:179-88.
10. de Jong EMGJ, Schalkwijk J, van de Kerkhof PCM. Epidermal proliferation and differentiation, composition of the inflammatory infiltrate and the extracellular matrix in the margin of the psoriatic lesion. Eur J Dermatol 1991; 1:221-7.
11. Mommers JM, van Rossum MM, van Erp PEJ et al. Changes in keratin 6 and keratin 10 (co-)expression in lesional and symptomless skin of spreading psoriasis. Dermatology 2000; 201: 15-20.
12. Janes SM, Lowell S, Hutter C. Epidermal stem cells. J Pathol 2002; 197:479-91.
13. Jones PH. Epithelial stem cells. Bioessays 1997; 19:683-90.
14. Watt FM. Epidermal stem cells: markers, patterning and the control of stem cell fate. Philos Trans R Soc Lond B Biol Sci 1998; 353:831-7.
15. Watt FM. The stem cell compartment in human interfollicular epidermis. J Dermatol Sci 2002; 28:173-80.
16. Jones PH, Harper S, Watt FM. Stem cell patterning and fate in human epidermis. Cell 1995; 80:83-93.
17. Cattoretti G, Becker MH, Key G et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992; 168:357-63.
18. Duchrow M, Gerdes J, Schluter C. The proliferation-associated Ki-67 protein: definition in molecular terms. Cell Prolif 1994; 27:235-42.
19. Leigh IM, Purkis PE, Whitehead P et al. Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation. Br J Dermatol 1993; 129:110-19.
20. Weiss RA, Eichner R, Sun TT. Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984; 98:1397-406.
21. Navarro JM, Casatorres J, Jorcano JL. Elements controlling the expression and induction of the skin hyperproliferation-associated keratin K6. J Biol Chem 1995; 270:21362-7.
22. Franssen ME, Zeeuwen PL, Vierwinden G et al. Phenotypical and functional differences in germinative subpopulations derived from normal and psoriatic epidermis. J Invest Dermatol 2005; 124:373-83.
23. Waseem A, Dogan B, Tidman N et al. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. J Invest Dermatol 1999; 112:362-9.
24. Werner S, Munz B. Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo. Exp Cell Res 2000; 254:80-90.
25. van Duijnhoven MWFM, van de Kerkhof PCM, Pasch MC et al. The combination of the Zenon labeling technique and microscopic image analysis to study cell populations in normal and psoriatic epidermis. J Cutan Pathol 2005; 32:212-19.
26. van Duijnhoven MWFM, Hagenberg G, Pasch MC et al. Novel quantitative immunofluorescent technique reveals improvements in epidermal cell populations after mild treatment of psoriasis. Acta Derm Venereol (Stockh) 2005; 85:311-17.
27. Castelijns FA, Gerritsen MJ, van Vlijmen-Willems IM et al. The epidermal phenotype during initiation of the psoriatic lesion in the symptomless margin of relapsing psoriasis. J Am Acad Dermatol 1999; 40:901-9.
28. van de Kerkhof PCM, van Rennes H, de Grood R et al. Metabolic changes at the margin of the spreading psoriatic lesion. Br J Dermatol 1983; 108:647-52.
29. van Pelt JP, Kuijpers SH, van de Kerkhof PCM et al. The CD11b/CD18-integrin in the pathogenesis of psoriasis. J Dermatol Sci 1998; 16:135-43.
30. Lowell S, Jones P, Le Roux I et al. Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol 2000; 10:491-500.
31. Chen G, McCormick TS, Hammerberg C et al. Basal keratinocytes from uninvolved psoriatic skin exhibit accelerated spreading and focal adhesion kinase responsiveness to fibronectin. J Invest Dermatol 2001; 117:1538-45.